| Full name: pleckstrin homology and RUN domain containing M1 | Alias Symbol: KIAA0356 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 9842 | HGNC ID: HGNC:29017 | Ensembl Gene: ENSG00000225190 | OMIM ID: 611466 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PLEKHM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHM1 | 9842 | 212717_at | -1.0281 | 0.1219 | |
| GSE20347 | PLEKHM1 | 9842 | 212717_at | -1.0625 | 0.0000 | |
| GSE23400 | PLEKHM1 | 9842 | 212717_at | -0.9737 | 0.0000 | |
| GSE26886 | PLEKHM1 | 9842 | 212717_at | -1.3863 | 0.0000 | |
| GSE29001 | PLEKHM1 | 9842 | 212717_at | -1.0871 | 0.0005 | |
| GSE38129 | PLEKHM1 | 9842 | 212717_at | -0.8037 | 0.0000 | |
| GSE45670 | PLEKHM1 | 9842 | 212717_at | -0.6127 | 0.0036 | |
| GSE53622 | PLEKHM1 | 9842 | 108106 | -1.4566 | 0.0000 | |
| GSE53624 | PLEKHM1 | 9842 | 108106 | -1.5320 | 0.0000 | |
| GSE63941 | PLEKHM1 | 9842 | 212717_at | -0.6959 | 0.0360 | |
| GSE77861 | PLEKHM1 | 9842 | 212717_at | -0.5463 | 0.1251 | |
| GSE97050 | PLEKHM1 | 9842 | A_33_P3405897 | -0.4847 | 0.3051 | |
| SRP007169 | PLEKHM1 | 9842 | RNAseq | -2.4064 | 0.0000 | |
| SRP008496 | PLEKHM1 | 9842 | RNAseq | -2.5768 | 0.0000 | |
| SRP064894 | PLEKHM1 | 9842 | RNAseq | -2.0320 | 0.0000 | |
| SRP133303 | PLEKHM1 | 9842 | RNAseq | -1.5492 | 0.0000 | |
| SRP159526 | PLEKHM1 | 9842 | RNAseq | -2.1121 | 0.0000 | |
| SRP193095 | PLEKHM1 | 9842 | RNAseq | -1.7801 | 0.0000 | |
| SRP219564 | PLEKHM1 | 9842 | RNAseq | -2.1435 | 0.0006 | |
| TCGA | PLEKHM1 | 9842 | RNAseq | -0.0905 | 0.2227 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by PLEKHM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHM1 | 9842 | 6 | 2 | 22 | |
| GSE20123 | PLEKHM1 | 9842 | 6 | 2 | 22 | |
| GSE43470 | PLEKHM1 | 9842 | 1 | 2 | 40 | |
| GSE46452 | PLEKHM1 | 9842 | 32 | 0 | 27 | |
| GSE47630 | PLEKHM1 | 9842 | 9 | 0 | 31 | |
| GSE54993 | PLEKHM1 | 9842 | 3 | 4 | 63 | |
| GSE54994 | PLEKHM1 | 9842 | 9 | 6 | 38 | |
| GSE60625 | PLEKHM1 | 9842 | 4 | 0 | 7 | |
| GSE74703 | PLEKHM1 | 9842 | 1 | 1 | 34 | |
| GSE74704 | PLEKHM1 | 9842 | 4 | 1 | 15 | |
| TCGA | PLEKHM1 | 9842 | 26 | 7 | 63 |
Total number of gains: 101; Total number of losses: 25; Total Number of normals: 362.
Somatic mutations of PLEKHM1:
Generating mutation plots.
Highly correlated genes for PLEKHM1:
Showing top 20/1730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHM1 | SMIM5 | 0.876333 | 6 | 0 | 6 |
| PLEKHM1 | VSIG10L | 0.861285 | 6 | 0 | 6 |
| PLEKHM1 | CYSRT1 | 0.857727 | 6 | 0 | 6 |
| PLEKHM1 | KRT78 | 0.855152 | 6 | 0 | 6 |
| PLEKHM1 | SCNN1B | 0.850138 | 10 | 0 | 10 |
| PLEKHM1 | MGLL | 0.842216 | 11 | 0 | 11 |
| PLEKHM1 | ARHGAP27 | 0.839738 | 8 | 0 | 8 |
| PLEKHM1 | TOM1 | 0.834687 | 12 | 0 | 11 |
| PLEKHM1 | TMPRSS11E | 0.832861 | 10 | 0 | 10 |
| PLEKHM1 | EVPL | 0.829638 | 11 | 0 | 10 |
| PLEKHM1 | PPL | 0.826766 | 11 | 0 | 11 |
| PLEKHM1 | EHD3 | 0.821757 | 11 | 0 | 11 |
| PLEKHM1 | EPS8L1 | 0.821435 | 11 | 0 | 10 |
| PLEKHM1 | ULK3 | 0.815892 | 7 | 0 | 7 |
| PLEKHM1 | PSCA | 0.815514 | 8 | 0 | 8 |
| PLEKHM1 | EMP1 | 0.814543 | 10 | 0 | 10 |
| PLEKHM1 | TTC9 | 0.814369 | 11 | 0 | 11 |
| PLEKHM1 | SLC16A6 | 0.814296 | 11 | 0 | 11 |
| PLEKHM1 | CAPN14 | 0.813743 | 6 | 0 | 6 |
| PLEKHM1 | TMPRSS11B | 0.813734 | 6 | 0 | 6 |
For details and further investigation, click here
