| Full name: otopetrin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 92736 | HGNC ID: HGNC:19657 | Ensembl Gene: ENSG00000183034 | OMIM ID: 607827 |
| Drug and gene relationship at DGIdb | |||
Expression of OTOP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OTOP2 | 92736 | 234551_at | -0.0794 | 0.7304 | |
| GSE26886 | OTOP2 | 92736 | 234551_at | 0.0204 | 0.8841 | |
| GSE45670 | OTOP2 | 92736 | 234551_at | 0.0322 | 0.7589 | |
| GSE53622 | OTOP2 | 92736 | 22555 | -0.3180 | 0.0004 | |
| GSE53624 | OTOP2 | 92736 | 22555 | -0.4057 | 0.0000 | |
| GSE63941 | OTOP2 | 92736 | 234551_at | 0.1165 | 0.5405 | |
| GSE77861 | OTOP2 | 92736 | 234551_at | -0.0241 | 0.8413 | |
| GSE97050 | OTOP2 | 92736 | A_33_P3226099 | -0.1395 | 0.6831 | |
| SRP007169 | OTOP2 | 92736 | RNAseq | -1.9823 | 0.0184 | |
| SRP064894 | OTOP2 | 92736 | RNAseq | -3.0058 | 0.0000 | |
| SRP133303 | OTOP2 | 92736 | RNAseq | -4.4758 | 0.0000 | |
| SRP159526 | OTOP2 | 92736 | RNAseq | -0.5887 | 0.5071 | |
| TCGA | OTOP2 | 92736 | RNAseq | 0.1934 | 0.7748 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by OTOP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTOP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTOP2 | 92736 | 6 | 2 | 22 | |
| GSE20123 | OTOP2 | 92736 | 6 | 2 | 22 | |
| GSE43470 | OTOP2 | 92736 | 5 | 3 | 35 | |
| GSE46452 | OTOP2 | 92736 | 33 | 0 | 26 | |
| GSE47630 | OTOP2 | 92736 | 8 | 1 | 31 | |
| GSE54993 | OTOP2 | 92736 | 2 | 5 | 63 | |
| GSE54994 | OTOP2 | 92736 | 10 | 4 | 39 | |
| GSE60625 | OTOP2 | 92736 | 6 | 0 | 5 | |
| GSE74703 | OTOP2 | 92736 | 5 | 1 | 30 | |
| GSE74704 | OTOP2 | 92736 | 4 | 1 | 15 | |
| TCGA | OTOP2 | 92736 | 32 | 10 | 54 |
Total number of gains: 117; Total number of losses: 29; Total Number of normals: 342.
Somatic mutations of OTOP2:
Generating mutation plots.
Highly correlated genes for OTOP2:
Showing top 20/249 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTOP2 | GALR2 | 0.787957 | 3 | 0 | 3 |
| OTOP2 | C11orf94 | 0.776299 | 3 | 0 | 3 |
| OTOP2 | CTSE | 0.76724 | 3 | 0 | 3 |
| OTOP2 | MFSD2B | 0.756561 | 3 | 0 | 3 |
| OTOP2 | TEX13A | 0.744566 | 3 | 0 | 3 |
| OTOP2 | C3orf36 | 0.734538 | 3 | 0 | 3 |
| OTOP2 | WDR83 | 0.732913 | 3 | 0 | 3 |
| OTOP2 | SYCE3 | 0.732278 | 4 | 0 | 3 |
| OTOP2 | ADRA1A | 0.712513 | 3 | 0 | 3 |
| OTOP2 | OR3A2 | 0.70594 | 3 | 0 | 3 |
| OTOP2 | CHMP1A | 0.698563 | 3 | 0 | 3 |
| OTOP2 | GCM2 | 0.698023 | 3 | 0 | 3 |
| OTOP2 | KCNQ4 | 0.69773 | 3 | 0 | 3 |
| OTOP2 | OR2Z1 | 0.693428 | 3 | 0 | 3 |
| OTOP2 | PTK6 | 0.690953 | 3 | 0 | 3 |
| OTOP2 | KRTAP20-1 | 0.684375 | 3 | 0 | 3 |
| OTOP2 | DNAJB8 | 0.682102 | 3 | 0 | 3 |
| OTOP2 | CYP2D6 | 0.680601 | 4 | 0 | 4 |
| OTOP2 | CD164L2 | 0.678588 | 3 | 0 | 3 |
| OTOP2 | TEN1 | 0.678039 | 3 | 0 | 3 |
For details and further investigation, click here
