ADRA1A

 

Full name: adrenoceptor alpha 1A Alias Symbol: ADRA1L1
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 148 HGNC ID: HGNC:277 Ensembl Gene: ENSG00000120907 OMIM ID: 104221
Drug and gene relationship at DGIdb

 

ADRA1A involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion

 

Expression of ADRA1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADRA1A 148 211490_at -0.1359 0.6507
GSE20347 ADRA1A 148 211491_at -0.0153 0.8627
GSE23400 ADRA1A 148 211489_at -0.0895 0.0031
GSE26886 ADRA1A 148 211491_at -0.0151 0.9053
GSE29001 ADRA1A 148 211491_at -0.0702 0.5843
GSE38129 ADRA1A 148 211490_at 0.0229 0.7262
GSE45670 ADRA1A 148 211490_at 0.0439 0.7050
GSE53622 ADRA1A 148 93908 0.4630 0.0000
GSE53624 ADRA1A 148 93908 0.3900 0.0000
GSE63941 ADRA1A 148 211490_at 0.3039 0.0982
GSE77861 ADRA1A 148 211491_at -0.0749 0.3865
GSE97050 ADRA1A 148 A_33_P3377194 0.1091 0.6337
SRP133303 ADRA1A 148 RNAseq -2.5951 0.0000
TCGA ADRA1A 148 RNAseq -2.7717 0.0015

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by ADRA1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADRA1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADRA1A 148 4 12 14
GSE20123 ADRA1A 148 4 12 14
GSE43470 ADRA1A 148 4 7 32
GSE46452 ADRA1A 148 13 13 33
GSE47630 ADRA1A 148 10 8 22
GSE54993 ADRA1A 148 2 15 53
GSE54994 ADRA1A 148 9 16 28
GSE60625 ADRA1A 148 3 0 8
GSE74703 ADRA1A 148 4 6 26
GSE74704 ADRA1A 148 3 8 9
TCGA ADRA1A 148 15 44 37

Total number of gains: 71; Total number of losses: 141; Total Number of normals: 276.  

 

Somatic mutations of ADRA1A:

 

Generating mutation plots.

 

Highly correlated genes for ADRA1A:

 

Showing top 20/717 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADRA1AC19orf440.774311303
ADRA1ATMEM1020.75252404
ADRA1ALRRC100.745825303
ADRA1ASTRC0.742039303
ADRA1ANHLRC40.741944303
ADRA1AKCNJ30.739298303
ADRA1AGPR620.733541303
ADRA1AMYH7B0.732931303
ADRA1AB3GALT10.722232403
ADRA1AREG3A0.716005303
ADRA1ANPBWR10.71451303
ADRA1AGREB1L0.714047303
ADRA1AOTOP20.712513303
ADRA1ADCDC10.706884303
ADRA1AZNF5170.703827303
ADRA1ASLC6A130.69983505
ADRA1ACHRD0.698449404
ADRA1ACDH160.697145303
ADRA1AC1QL20.694973303
ADRA1APLA2G2C0.694942303

For details and further investigation, click here