| Full name: purinergic receptor P2X 1 | Alias Symbol: P2X1 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 5023 | HGNC ID: HGNC:8533 | Ensembl Gene: ENSG00000108405 | OMIM ID: 600845 |
| Drug and gene relationship at DGIdb | |||
P2RX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04611 | Platelet activation |
Expression of P2RX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX1 | 5023 | 210401_at | -1.0208 | 0.1159 | |
| GSE20347 | P2RX1 | 5023 | 210401_at | -0.0861 | 0.5107 | |
| GSE23400 | P2RX1 | 5023 | 210401_at | -0.5290 | 0.0000 | |
| GSE26886 | P2RX1 | 5023 | 210401_at | -0.1985 | 0.2606 | |
| GSE29001 | P2RX1 | 5023 | 210401_at | -0.1921 | 0.3144 | |
| GSE38129 | P2RX1 | 5023 | 210401_at | -0.3399 | 0.0032 | |
| GSE45670 | P2RX1 | 5023 | 210401_at | -0.9086 | 0.0000 | |
| GSE53622 | P2RX1 | 5023 | 11885 | -1.0835 | 0.0000 | |
| GSE53624 | P2RX1 | 5023 | 11885 | -1.0159 | 0.0000 | |
| GSE63941 | P2RX1 | 5023 | 210401_at | 0.1142 | 0.5229 | |
| GSE77861 | P2RX1 | 5023 | 210401_at | -0.1391 | 0.0416 | |
| GSE97050 | P2RX1 | 5023 | A_23_P372848 | -0.4736 | 0.1279 | |
| SRP064894 | P2RX1 | 5023 | RNAseq | -2.0736 | 0.0000 | |
| SRP133303 | P2RX1 | 5023 | RNAseq | -2.3719 | 0.0000 | |
| SRP159526 | P2RX1 | 5023 | RNAseq | -2.8852 | 0.0004 | |
| SRP219564 | P2RX1 | 5023 | RNAseq | -3.2072 | 0.0000 | |
| TCGA | P2RX1 | 5023 | RNAseq | -1.4654 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by P2RX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX1 | 5023 | 5 | 3 | 22 | |
| GSE20123 | P2RX1 | 5023 | 5 | 4 | 21 | |
| GSE43470 | P2RX1 | 5023 | 1 | 6 | 36 | |
| GSE46452 | P2RX1 | 5023 | 34 | 1 | 24 | |
| GSE47630 | P2RX1 | 5023 | 7 | 1 | 32 | |
| GSE54993 | P2RX1 | 5023 | 4 | 3 | 63 | |
| GSE54994 | P2RX1 | 5023 | 5 | 9 | 39 | |
| GSE60625 | P2RX1 | 5023 | 4 | 0 | 7 | |
| GSE74703 | P2RX1 | 5023 | 1 | 3 | 32 | |
| GSE74704 | P2RX1 | 5023 | 3 | 2 | 15 | |
| TCGA | P2RX1 | 5023 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 53; Total Number of normals: 348.
Somatic mutations of P2RX1:
Generating mutation plots.
Highly correlated genes for P2RX1:
Showing top 20/1176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX1 | RNF150 | 0.748187 | 4 | 0 | 4 |
| P2RX1 | RAB9B | 0.731271 | 5 | 0 | 4 |
| P2RX1 | SSPN | 0.726299 | 3 | 0 | 3 |
| P2RX1 | ANGPTL1 | 0.724625 | 5 | 0 | 5 |
| P2RX1 | GRHPR | 0.723508 | 3 | 0 | 3 |
| P2RX1 | ITGA9 | 0.720466 | 5 | 0 | 5 |
| P2RX1 | VMAC | 0.716882 | 3 | 0 | 3 |
| P2RX1 | PDCD4 | 0.711137 | 3 | 0 | 3 |
| P2RX1 | LACTBL1 | 0.702751 | 3 | 0 | 3 |
| P2RX1 | LRFN5 | 0.700843 | 3 | 0 | 3 |
| P2RX1 | ANKRD12 | 0.697583 | 3 | 0 | 3 |
| P2RX1 | ZNF608 | 0.697455 | 4 | 0 | 4 |
| P2RX1 | XPA | 0.695907 | 3 | 0 | 3 |
| P2RX1 | PCP4 | 0.692867 | 9 | 0 | 8 |
| P2RX1 | CCDC3 | 0.688282 | 5 | 0 | 4 |
| P2RX1 | BRINP2 | 0.685191 | 4 | 0 | 4 |
| P2RX1 | TMEM61 | 0.683101 | 4 | 0 | 4 |
| P2RX1 | C1QTNF7 | 0.680841 | 5 | 0 | 5 |
| P2RX1 | SLMAP | 0.675167 | 6 | 0 | 6 |
| P2RX1 | KLHDC8B | 0.67291 | 4 | 0 | 4 |
For details and further investigation, click here
