| Full name: Purkinje cell protein 4 | Alias Symbol: PEP-19 | ||
| Type: protein-coding gene | Cytoband: 21q22.2 | ||
| Entrez ID: 5121 | HGNC ID: HGNC:8742 | Ensembl Gene: ENSG00000183036 | OMIM ID: 601629 |
| Drug and gene relationship at DGIdb | |||
Expression of PCP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCP4 | 5121 | 205549_at | -3.2752 | 0.0248 | |
| GSE20347 | PCP4 | 5121 | 205549_at | -1.4571 | 0.0019 | |
| GSE23400 | PCP4 | 5121 | 205549_at | -1.5096 | 0.0000 | |
| GSE26886 | PCP4 | 5121 | 205549_at | 0.6905 | 0.1327 | |
| GSE29001 | PCP4 | 5121 | 205549_at | -1.2582 | 0.0249 | |
| GSE38129 | PCP4 | 5121 | 205549_at | -1.9071 | 0.0010 | |
| GSE45670 | PCP4 | 5121 | 205549_at | -4.6813 | 0.0000 | |
| GSE53622 | PCP4 | 5121 | 21248 | -3.8090 | 0.0000 | |
| GSE53624 | PCP4 | 5121 | 21248 | -3.6414 | 0.0000 | |
| GSE63941 | PCP4 | 5121 | 205549_at | 0.0487 | 0.8638 | |
| GSE77861 | PCP4 | 5121 | 205549_at | 0.0202 | 0.9194 | |
| GSE97050 | PCP4 | 5121 | A_23_P109322 | -1.6518 | 0.1143 | |
| SRP064894 | PCP4 | 5121 | RNAseq | -1.6696 | 0.0178 | |
| SRP133303 | PCP4 | 5121 | RNAseq | -3.3851 | 0.0001 | |
| SRP159526 | PCP4 | 5121 | RNAseq | -3.2906 | 0.0005 | |
| SRP219564 | PCP4 | 5121 | RNAseq | -1.8944 | 0.0567 | |
| TCGA | PCP4 | 5121 | RNAseq | -1.3780 | 0.0323 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by PCP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCP4 | 5121 | 2 | 11 | 17 | |
| GSE20123 | PCP4 | 5121 | 2 | 11 | 17 | |
| GSE43470 | PCP4 | 5121 | 0 | 10 | 33 | |
| GSE46452 | PCP4 | 5121 | 1 | 21 | 37 | |
| GSE47630 | PCP4 | 5121 | 6 | 17 | 17 | |
| GSE54993 | PCP4 | 5121 | 8 | 1 | 61 | |
| GSE54994 | PCP4 | 5121 | 3 | 8 | 42 | |
| GSE60625 | PCP4 | 5121 | 0 | 0 | 11 | |
| GSE74703 | PCP4 | 5121 | 0 | 8 | 28 | |
| GSE74704 | PCP4 | 5121 | 1 | 7 | 12 | |
| TCGA | PCP4 | 5121 | 8 | 42 | 46 |
Total number of gains: 31; Total number of losses: 136; Total Number of normals: 321.
Somatic mutations of PCP4:
Generating mutation plots.
Highly correlated genes for PCP4:
Showing top 20/1090 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCP4 | MYOCD | 0.865161 | 6 | 0 | 6 |
| PCP4 | CYP21A2 | 0.850221 | 3 | 0 | 3 |
| PCP4 | ASB5 | 0.847665 | 5 | 0 | 5 |
| PCP4 | SLMAP | 0.843329 | 5 | 0 | 5 |
| PCP4 | ATP1A2 | 0.84033 | 10 | 0 | 10 |
| PCP4 | LINC01082 | 0.839536 | 4 | 0 | 4 |
| PCP4 | LMOD1 | 0.833428 | 11 | 0 | 11 |
| PCP4 | PPP1R12B | 0.820982 | 10 | 0 | 10 |
| PCP4 | XKR4 | 0.820622 | 5 | 0 | 5 |
| PCP4 | CLEC3B | 0.819931 | 3 | 0 | 3 |
| PCP4 | SYNM | 0.817735 | 11 | 0 | 11 |
| PCP4 | BOC | 0.816874 | 5 | 0 | 5 |
| PCP4 | ADAMTS9-AS2 | 0.816712 | 5 | 0 | 5 |
| PCP4 | CNN1 | 0.81635 | 9 | 0 | 9 |
| PCP4 | SORCS1 | 0.816191 | 4 | 0 | 4 |
| PCP4 | PTCHD1 | 0.814606 | 5 | 0 | 5 |
| PCP4 | GFRA1 | 0.811915 | 5 | 0 | 5 |
| PCP4 | PRUNE2 | 0.810404 | 11 | 0 | 11 |
| PCP4 | NFIA | 0.809623 | 5 | 0 | 5 |
| PCP4 | ACTG2 | 0.805304 | 11 | 0 | 11 |
For details and further investigation, click here
