| Full name: XPA, DNA damage recognition and repair factor | Alias Symbol: XPAC|XP1 | ||
| Type: protein-coding gene | Cytoband: 9q22.33 | ||
| Entrez ID: 7507 | HGNC ID: HGNC:12814 | Ensembl Gene: ENSG00000136936 | OMIM ID: 611153 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XPA | 7507 | 205672_at | -1.0532 | 0.0090 | |
| GSE20347 | XPA | 7507 | 205672_at | -0.5186 | 0.0161 | |
| GSE23400 | XPA | 7507 | 205672_at | -0.1216 | 0.2501 | |
| GSE26886 | XPA | 7507 | 205672_at | -0.3361 | 0.3534 | |
| GSE29001 | XPA | 7507 | 205672_at | -0.4357 | 0.1512 | |
| GSE38129 | XPA | 7507 | 205672_at | -0.5353 | 0.0012 | |
| GSE45670 | XPA | 7507 | 205672_at | -0.2590 | 0.2591 | |
| GSE53622 | XPA | 7507 | 8703 | -0.8253 | 0.0000 | |
| GSE53624 | XPA | 7507 | 8703 | -0.6164 | 0.0000 | |
| GSE63941 | XPA | 7507 | 205672_at | -0.1758 | 0.7262 | |
| GSE77861 | XPA | 7507 | 205672_at | 0.0833 | 0.8054 | |
| GSE97050 | XPA | 7507 | A_23_P60283 | -0.9936 | 0.0607 | |
| SRP007169 | XPA | 7507 | RNAseq | -0.3313 | 0.5591 | |
| SRP008496 | XPA | 7507 | RNAseq | -0.1239 | 0.7332 | |
| SRP064894 | XPA | 7507 | RNAseq | -0.3911 | 0.0581 | |
| SRP133303 | XPA | 7507 | RNAseq | -0.4414 | 0.0010 | |
| SRP159526 | XPA | 7507 | RNAseq | -0.4916 | 0.0798 | |
| SRP193095 | XPA | 7507 | RNAseq | -0.3275 | 0.0208 | |
| SRP219564 | XPA | 7507 | RNAseq | -0.7068 | 0.0456 | |
| TCGA | XPA | 7507 | RNAseq | -0.3674 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by XPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XPA | 7507 | 7 | 8 | 15 | |
| GSE20123 | XPA | 7507 | 7 | 7 | 16 | |
| GSE43470 | XPA | 7507 | 6 | 3 | 34 | |
| GSE46452 | XPA | 7507 | 6 | 14 | 39 | |
| GSE47630 | XPA | 7507 | 1 | 17 | 22 | |
| GSE54993 | XPA | 7507 | 3 | 3 | 64 | |
| GSE54994 | XPA | 7507 | 8 | 11 | 34 | |
| GSE60625 | XPA | 7507 | 0 | 0 | 11 | |
| GSE74703 | XPA | 7507 | 5 | 3 | 28 | |
| GSE74704 | XPA | 7507 | 3 | 5 | 12 | |
| TCGA | XPA | 7507 | 27 | 22 | 47 |
Total number of gains: 73; Total number of losses: 93; Total Number of normals: 322.
Somatic mutations of XPA:
Generating mutation plots.
Highly correlated genes for XPA:
Showing top 20/634 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XPA | ANKRD6 | 0.799934 | 3 | 0 | 3 |
| XPA | KDM3B | 0.752319 | 3 | 0 | 3 |
| XPA | HOXA3 | 0.748959 | 3 | 0 | 3 |
| XPA | SLTM | 0.735677 | 4 | 0 | 4 |
| XPA | PTGIS | 0.717531 | 3 | 0 | 3 |
| XPA | ZNF844 | 0.707213 | 3 | 0 | 3 |
| XPA | EIF4E3 | 0.705027 | 4 | 0 | 3 |
| XPA | TSPAN31 | 0.703196 | 3 | 0 | 3 |
| XPA | LONRF2 | 0.699196 | 4 | 0 | 4 |
| XPA | P2RX1 | 0.695907 | 3 | 0 | 3 |
| XPA | ZNF662 | 0.691825 | 4 | 0 | 3 |
| XPA | EIF4B | 0.690941 | 3 | 0 | 3 |
| XPA | BMX | 0.689385 | 4 | 0 | 4 |
| XPA | RRAGA | 0.68811 | 5 | 0 | 5 |
| XPA | RIC3 | 0.686556 | 4 | 0 | 3 |
| XPA | LRRK2 | 0.685728 | 4 | 0 | 4 |
| XPA | TOX4 | 0.68463 | 3 | 0 | 3 |
| XPA | TPCN1 | 0.682123 | 3 | 0 | 3 |
| XPA | HAGH | 0.680557 | 3 | 0 | 3 |
| XPA | CFD | 0.680315 | 5 | 0 | 4 |
For details and further investigation, click here
