PAX5

 

Full name: paired box 5 Alias Symbol: BSAP
Type: protein-coding gene Cytoband: 9p13.2
Entrez ID: 5079 HGNC ID: HGNC:8619 Ensembl Gene: ENSG00000196092 OMIM ID: 167414
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 5/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PAX5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PAX5 5079 221969_at 0.5708 0.7055
GSE20347 PAX5 5079 221969_at 0.5063 0.0844
GSE23400 PAX5 5079 206802_at -0.2129 0.0000
GSE26886 PAX5 5079 206802_at 0.3736 0.0037
GSE29001 PAX5 5079 221969_at 1.7552 0.0054
GSE38129 PAX5 5079 221969_at 0.3292 0.3832
GSE45670 PAX5 5079 221969_at 0.5581 0.3022
GSE53622 PAX5 5079 43078 -1.0294 0.0006
GSE53624 PAX5 5079 110423 -0.2000 0.0547
GSE63941 PAX5 5079 206802_at 0.0618 0.7362
GSE77861 PAX5 5079 206802_at -0.0873 0.6251
GSE97050 PAX5 5079 A_23_P71624 0.5574 0.2151
SRP133303 PAX5 5079 RNAseq -0.8573 0.1256
SRP159526 PAX5 5079 RNAseq -2.0917 0.0662
SRP193095 PAX5 5079 RNAseq 0.3548 0.3757
SRP219564 PAX5 5079 RNAseq 2.1918 0.0039
TCGA PAX5 5079 RNAseq 0.0813 0.8868

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by PAX5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PAX5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PAX5 5079 3 12 15
GSE20123 PAX5 5079 3 12 15
GSE43470 PAX5 5079 1 12 30
GSE46452 PAX5 5079 6 15 38
GSE47630 PAX5 5079 1 20 19
GSE54993 PAX5 5079 6 0 64
GSE54994 PAX5 5079 5 13 35
GSE60625 PAX5 5079 0 0 11
GSE74703 PAX5 5079 1 8 27
GSE74704 PAX5 5079 0 10 10
TCGA PAX5 5079 14 44 38

Total number of gains: 40; Total number of losses: 146; Total Number of normals: 302.  

 

Somatic mutations of PAX5:

 

Generating mutation plots.

 

Highly correlated genes for PAX5:

 

Showing top 20/288 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PAX5SIX10.780894303
PAX5ECE20.730054303
PAX5CPSF10.708577404
PAX5ZC3H12D0.70483404
PAX5ACTL6B0.701597303
PAX5ZNF7710.701381303
PAX5ADM20.699517303
PAX5TP53TG50.697446303
PAX5GPR1620.695556303
PAX5FUZ0.693098303
PAX5TBX10.687356404
PAX5CCDC1340.684467404
PAX5CLEC17A0.683929303
PAX5FERMT30.683921404
PAX5KLK150.682936303
PAX5LPA0.679605303
PAX5FCRL50.676267503
PAX5FANCE0.675514303
PAX5CCDC1510.674998303
PAX5HOXD110.667704303

For details and further investigation, click here