| Full name: cleavage and polyadenylation specific factor 1 | Alias Symbol: CPSF160 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 29894 | HGNC ID: HGNC:2324 | Ensembl Gene: ENSG00000071894 | OMIM ID: 606027 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CPSF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPSF1 | 29894 | 201638_s_at | 0.1051 | 0.7390 | |
| GSE20347 | CPSF1 | 29894 | 201638_s_at | 0.0994 | 0.1358 | |
| GSE23400 | CPSF1 | 29894 | 201638_s_at | -0.0859 | 0.0625 | |
| GSE26886 | CPSF1 | 29894 | 201638_s_at | 0.1241 | 0.2579 | |
| GSE29001 | CPSF1 | 29894 | 201638_s_at | -0.0856 | 0.5765 | |
| GSE38129 | CPSF1 | 29894 | 201638_s_at | -0.0161 | 0.8359 | |
| GSE45670 | CPSF1 | 29894 | 201638_s_at | 0.1474 | 0.0641 | |
| GSE53622 | CPSF1 | 29894 | 95917 | 0.7662 | 0.0000 | |
| GSE53624 | CPSF1 | 29894 | 108215 | 0.7376 | 0.0000 | |
| GSE63941 | CPSF1 | 29894 | 201638_s_at | 0.7945 | 0.0063 | |
| GSE77861 | CPSF1 | 29894 | 201638_s_at | 0.1065 | 0.2895 | |
| GSE97050 | CPSF1 | 29894 | A_23_P169112 | 0.3797 | 0.2319 | |
| SRP007169 | CPSF1 | 29894 | RNAseq | 1.5260 | 0.0039 | |
| SRP008496 | CPSF1 | 29894 | RNAseq | 1.7899 | 0.0000 | |
| SRP064894 | CPSF1 | 29894 | RNAseq | 1.0417 | 0.0000 | |
| SRP133303 | CPSF1 | 29894 | RNAseq | 0.3308 | 0.0145 | |
| SRP159526 | CPSF1 | 29894 | RNAseq | 0.5688 | 0.0263 | |
| SRP193095 | CPSF1 | 29894 | RNAseq | 0.6861 | 0.0001 | |
| TCGA | CPSF1 | 29894 | RNAseq | 0.0530 | 0.2550 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CPSF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPSF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPSF1 | 29894 | 17 | 1 | 12 | |
| GSE20123 | CPSF1 | 29894 | 17 | 1 | 12 | |
| GSE43470 | CPSF1 | 29894 | 16 | 2 | 25 | |
| GSE46452 | CPSF1 | 29894 | 28 | 0 | 31 | |
| GSE47630 | CPSF1 | 29894 | 25 | 1 | 14 | |
| GSE54993 | CPSF1 | 29894 | 0 | 25 | 45 | |
| GSE54994 | CPSF1 | 29894 | 39 | 1 | 13 | |
| GSE60625 | CPSF1 | 29894 | 3 | 4 | 4 | |
| GSE74703 | CPSF1 | 29894 | 14 | 1 | 21 | |
| GSE74704 | CPSF1 | 29894 | 10 | 0 | 10 | |
| TCGA | CPSF1 | 29894 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of CPSF1:
Generating mutation plots.
Highly correlated genes for CPSF1:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPSF1 | PAX5 | 0.708577 | 4 | 0 | 4 |
| CPSF1 | SLC19A1 | 0.670168 | 3 | 0 | 3 |
| CPSF1 | ZGRF1 | 0.668636 | 3 | 0 | 3 |
| CPSF1 | NFE2 | 0.663934 | 3 | 0 | 3 |
| CPSF1 | ENTPD6 | 0.661211 | 3 | 0 | 3 |
| CPSF1 | FAM43A | 0.648024 | 3 | 0 | 3 |
| CPSF1 | BOP1 | 0.645357 | 4 | 0 | 4 |
| CPSF1 | MYBL2 | 0.644626 | 7 | 0 | 7 |
| CPSF1 | SPI1 | 0.643264 | 4 | 0 | 3 |
| CPSF1 | P2RX5 | 0.642538 | 3 | 0 | 3 |
| CPSF1 | AGER | 0.636712 | 3 | 0 | 3 |
| CPSF1 | CCDC42 | 0.635635 | 3 | 0 | 3 |
| CPSF1 | TIMD4 | 0.633066 | 3 | 0 | 3 |
| CPSF1 | KIF17 | 0.631684 | 4 | 0 | 4 |
| CPSF1 | FCGR2C | 0.627826 | 4 | 0 | 4 |
| CPSF1 | FOXD2-AS1 | 0.626134 | 4 | 0 | 3 |
| CPSF1 | ZFP41 | 0.624277 | 3 | 0 | 3 |
| CPSF1 | SMPD3 | 0.622812 | 3 | 0 | 3 |
| CPSF1 | MYH8 | 0.622689 | 3 | 0 | 3 |
| CPSF1 | LAT2 | 0.621502 | 5 | 0 | 4 |
For details and further investigation, click here
