| Full name: FA complementation group E | Alias Symbol: FAE | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 2178 | HGNC ID: HGNC:3586 | Ensembl Gene: ENSG00000112039 | OMIM ID: 613976 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCE involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCE | 2178 | 220255_at | 0.9425 | 0.1194 | |
| GSE20347 | FANCE | 2178 | 220255_at | 0.5004 | 0.0000 | |
| GSE23400 | FANCE | 2178 | 220255_at | 0.4707 | 0.0000 | |
| GSE26886 | FANCE | 2178 | 220255_at | 1.2967 | 0.0000 | |
| GSE29001 | FANCE | 2178 | 220255_at | 0.7121 | 0.0024 | |
| GSE38129 | FANCE | 2178 | 220255_at | 0.5789 | 0.0000 | |
| GSE45670 | FANCE | 2178 | 220255_at | 0.6692 | 0.0020 | |
| GSE53622 | FANCE | 2178 | 24871 | 0.7362 | 0.0000 | |
| GSE53624 | FANCE | 2178 | 24871 | 0.9873 | 0.0000 | |
| GSE63941 | FANCE | 2178 | 220255_at | 1.3141 | 0.0131 | |
| GSE77861 | FANCE | 2178 | 220255_at | 0.4330 | 0.1435 | |
| GSE97050 | FANCE | 2178 | A_23_P42335 | 0.1427 | 0.6216 | |
| SRP007169 | FANCE | 2178 | RNAseq | 0.4129 | 0.3911 | |
| SRP008496 | FANCE | 2178 | RNAseq | 0.0798 | 0.8113 | |
| SRP064894 | FANCE | 2178 | RNAseq | 0.6330 | 0.0129 | |
| SRP133303 | FANCE | 2178 | RNAseq | 0.5769 | 0.0016 | |
| SRP159526 | FANCE | 2178 | RNAseq | 0.7541 | 0.0057 | |
| SRP193095 | FANCE | 2178 | RNAseq | 0.7879 | 0.0000 | |
| SRP219564 | FANCE | 2178 | RNAseq | 1.0668 | 0.0697 | |
| TCGA | FANCE | 2178 | RNAseq | 0.5430 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FANCE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCE | 2178 | 5 | 0 | 25 | |
| GSE20123 | FANCE | 2178 | 5 | 0 | 25 | |
| GSE43470 | FANCE | 2178 | 5 | 1 | 37 | |
| GSE46452 | FANCE | 2178 | 2 | 9 | 48 | |
| GSE47630 | FANCE | 2178 | 8 | 4 | 28 | |
| GSE54993 | FANCE | 2178 | 3 | 1 | 66 | |
| GSE54994 | FANCE | 2178 | 11 | 4 | 38 | |
| GSE60625 | FANCE | 2178 | 1 | 0 | 10 | |
| GSE74703 | FANCE | 2178 | 5 | 0 | 31 | |
| GSE74704 | FANCE | 2178 | 2 | 0 | 18 | |
| TCGA | FANCE | 2178 | 15 | 15 | 66 |
Total number of gains: 62; Total number of losses: 34; Total Number of normals: 392.
Somatic mutations of FANCE:
Generating mutation plots.
Highly correlated genes for FANCE:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCE | MRPL14 | 0.733464 | 7 | 0 | 7 |
| FANCE | AGTRAP | 0.726821 | 3 | 0 | 3 |
| FANCE | PLCG1 | 0.725746 | 4 | 0 | 4 |
| FANCE | BPNT1 | 0.724864 | 3 | 0 | 3 |
| FANCE | IL18BP | 0.724068 | 3 | 0 | 3 |
| FANCE | RRP36 | 0.719081 | 7 | 0 | 7 |
| FANCE | MEX3C | 0.716745 | 3 | 0 | 3 |
| FANCE | COMMD2 | 0.715444 | 4 | 0 | 4 |
| FANCE | XPO5 | 0.710429 | 9 | 0 | 7 |
| FANCE | ZAP70 | 0.710218 | 4 | 0 | 4 |
| FANCE | PRR14 | 0.69479 | 3 | 0 | 3 |
| FANCE | GMNN | 0.694131 | 12 | 0 | 11 |
| FANCE | SFR1 | 0.693046 | 4 | 0 | 3 |
| FANCE | DKC1 | 0.691452 | 3 | 0 | 3 |
| FANCE | CCNE1 | 0.689057 | 7 | 0 | 7 |
| FANCE | TMEM189 | 0.685224 | 3 | 0 | 3 |
| FANCE | PET117 | 0.68344 | 3 | 0 | 3 |
| FANCE | NR1H3 | 0.682854 | 4 | 0 | 4 |
| FANCE | CD44 | 0.682647 | 3 | 0 | 3 |
| FANCE | TMEM237 | 0.681903 | 5 | 0 | 5 |
For details and further investigation, click here
