| Full name: T-box transcription factor 1 | Alias Symbol: CATCH22 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 6899 | HGNC ID: HGNC:11592 | Ensembl Gene: ENSG00000184058 | OMIM ID: 602054 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TBX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX1 | 6899 | 236926_at | 1.1370 | 0.1787 | |
| GSE20347 | TBX1 | 6899 | 211274_at | 0.1495 | 0.0664 | |
| GSE23400 | TBX1 | 6899 | 211274_at | -0.0733 | 0.0295 | |
| GSE26886 | TBX1 | 6899 | 236926_at | 1.0490 | 0.0000 | |
| GSE29001 | TBX1 | 6899 | 211274_at | 0.3741 | 0.0571 | |
| GSE38129 | TBX1 | 6899 | 207662_at | -0.0542 | 0.3504 | |
| GSE45670 | TBX1 | 6899 | 236926_at | 0.4011 | 0.0406 | |
| GSE53622 | TBX1 | 6899 | 27619 | 1.0014 | 0.0000 | |
| GSE53624 | TBX1 | 6899 | 27619 | 0.8734 | 0.0000 | |
| GSE63941 | TBX1 | 6899 | 236926_at | 0.9689 | 0.1998 | |
| GSE77861 | TBX1 | 6899 | 236926_at | 0.3431 | 0.0284 | |
| GSE97050 | TBX1 | 6899 | A_23_P40527 | 1.1620 | 0.0866 | |
| SRP064894 | TBX1 | 6899 | RNAseq | 1.5277 | 0.0000 | |
| SRP133303 | TBX1 | 6899 | RNAseq | 0.4879 | 0.0520 | |
| SRP159526 | TBX1 | 6899 | RNAseq | 2.9724 | 0.0000 | |
| SRP193095 | TBX1 | 6899 | RNAseq | 1.5424 | 0.0000 | |
| SRP219564 | TBX1 | 6899 | RNAseq | 1.5872 | 0.0185 | |
| TCGA | TBX1 | 6899 | RNAseq | 0.9947 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by TBX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX1 | 6899 | 5 | 7 | 18 | |
| GSE20123 | TBX1 | 6899 | 5 | 7 | 18 | |
| GSE43470 | TBX1 | 6899 | 4 | 7 | 32 | |
| GSE46452 | TBX1 | 6899 | 33 | 1 | 25 | |
| GSE47630 | TBX1 | 6899 | 8 | 5 | 27 | |
| GSE54993 | TBX1 | 6899 | 3 | 6 | 61 | |
| GSE54994 | TBX1 | 6899 | 12 | 7 | 34 | |
| GSE60625 | TBX1 | 6899 | 5 | 0 | 6 | |
| GSE74703 | TBX1 | 6899 | 4 | 5 | 27 | |
| GSE74704 | TBX1 | 6899 | 3 | 4 | 13 | |
| TCGA | TBX1 | 6899 | 27 | 17 | 52 |
Total number of gains: 109; Total number of losses: 66; Total Number of normals: 313.
Somatic mutations of TBX1:
Generating mutation plots.
Highly correlated genes for TBX1:
Showing top 20/1023 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX1 | MAN2B1 | 0.827054 | 3 | 0 | 3 |
| TBX1 | RNF40 | 0.788002 | 3 | 0 | 3 |
| TBX1 | ZNF764 | 0.770475 | 3 | 0 | 3 |
| TBX1 | SLC25A13 | 0.770229 | 3 | 0 | 3 |
| TBX1 | AKR1B1 | 0.756049 | 4 | 0 | 4 |
| TBX1 | IWS1 | 0.752356 | 3 | 0 | 3 |
| TBX1 | GMCL1 | 0.745145 | 3 | 0 | 3 |
| TBX1 | TMEM223 | 0.73119 | 4 | 0 | 4 |
| TBX1 | TMEM60 | 0.728372 | 3 | 0 | 3 |
| TBX1 | NENF | 0.725047 | 3 | 0 | 3 |
| TBX1 | DGUOK | 0.718607 | 5 | 0 | 4 |
| TBX1 | CAPN12 | 0.717356 | 3 | 0 | 3 |
| TBX1 | PCSK1 | 0.714189 | 3 | 0 | 3 |
| TBX1 | FJX1 | 0.712339 | 5 | 0 | 5 |
| TBX1 | UBB | 0.711269 | 3 | 0 | 3 |
| TBX1 | LSM1 | 0.70979 | 3 | 0 | 3 |
| TBX1 | DVL2 | 0.709532 | 3 | 0 | 3 |
| TBX1 | BCAR1 | 0.706575 | 5 | 0 | 5 |
| TBX1 | CDC42EP4 | 0.702861 | 3 | 0 | 3 |
| TBX1 | GSR | 0.702254 | 3 | 0 | 3 |
For details and further investigation, click here
