| Full name: protein-L-isoaspartate (D-aspartate) O-methyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q25.1 | ||
| Entrez ID: 5110 | HGNC ID: HGNC:8728 | Ensembl Gene: ENSG00000120265 | OMIM ID: 176851 |
| Drug and gene relationship at DGIdb | |||
Expression of PCMT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCMT1 | 5110 | 205202_at | -0.3915 | 0.3292 | |
| GSE20347 | PCMT1 | 5110 | 205202_at | -0.1448 | 0.4122 | |
| GSE23400 | PCMT1 | 5110 | 205202_at | 0.1579 | 0.0354 | |
| GSE26886 | PCMT1 | 5110 | 205202_at | -0.0482 | 0.8119 | |
| GSE29001 | PCMT1 | 5110 | 205202_at | 0.0752 | 0.8007 | |
| GSE38129 | PCMT1 | 5110 | 205202_at | -0.1489 | 0.2583 | |
| GSE45670 | PCMT1 | 5110 | 205202_at | -0.1978 | 0.0288 | |
| GSE53622 | PCMT1 | 5110 | 45337 | 0.1319 | 0.0204 | |
| GSE53624 | PCMT1 | 5110 | 45337 | 0.1311 | 0.0779 | |
| GSE63941 | PCMT1 | 5110 | 210156_s_at | 0.6466 | 0.0344 | |
| GSE77861 | PCMT1 | 5110 | 210156_s_at | -0.0365 | 0.9221 | |
| GSE97050 | PCMT1 | 5110 | A_33_P3393573 | 0.3822 | 0.1533 | |
| SRP007169 | PCMT1 | 5110 | RNAseq | -0.7221 | 0.0149 | |
| SRP008496 | PCMT1 | 5110 | RNAseq | -0.5554 | 0.0055 | |
| SRP064894 | PCMT1 | 5110 | RNAseq | 0.0270 | 0.8587 | |
| SRP133303 | PCMT1 | 5110 | RNAseq | 0.1815 | 0.2983 | |
| SRP159526 | PCMT1 | 5110 | RNAseq | -0.3730 | 0.0710 | |
| SRP193095 | PCMT1 | 5110 | RNAseq | -0.3018 | 0.0282 | |
| SRP219564 | PCMT1 | 5110 | RNAseq | -0.3579 | 0.3794 | |
| TCGA | PCMT1 | 5110 | RNAseq | -0.0149 | 0.7548 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PCMT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCMT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCMT1 | 5110 | 2 | 4 | 24 | |
| GSE20123 | PCMT1 | 5110 | 1 | 3 | 26 | |
| GSE43470 | PCMT1 | 5110 | 4 | 0 | 39 | |
| GSE46452 | PCMT1 | 5110 | 3 | 10 | 46 | |
| GSE47630 | PCMT1 | 5110 | 9 | 4 | 27 | |
| GSE54993 | PCMT1 | 5110 | 3 | 2 | 65 | |
| GSE54994 | PCMT1 | 5110 | 8 | 8 | 37 | |
| GSE60625 | PCMT1 | 5110 | 0 | 1 | 10 | |
| GSE74703 | PCMT1 | 5110 | 4 | 0 | 32 | |
| GSE74704 | PCMT1 | 5110 | 0 | 1 | 19 | |
| TCGA | PCMT1 | 5110 | 11 | 21 | 64 |
Total number of gains: 45; Total number of losses: 54; Total Number of normals: 389.
Somatic mutations of PCMT1:
Generating mutation plots.
Highly correlated genes for PCMT1:
Showing top 20/415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCMT1 | ZNF394 | 0.856447 | 3 | 0 | 3 |
| PCMT1 | TMEM234 | 0.753936 | 3 | 0 | 3 |
| PCMT1 | PPIL4 | 0.75102 | 4 | 0 | 4 |
| PCMT1 | SARNP | 0.744892 | 4 | 0 | 4 |
| PCMT1 | HCCS | 0.708343 | 5 | 0 | 5 |
| PCMT1 | GLUD2 | 0.706948 | 4 | 0 | 3 |
| PCMT1 | FAM83D | 0.693077 | 4 | 0 | 3 |
| PCMT1 | RACGAP1 | 0.690025 | 4 | 0 | 4 |
| PCMT1 | EEA1 | 0.687041 | 3 | 0 | 3 |
| PCMT1 | GDE1 | 0.684616 | 4 | 0 | 4 |
| PCMT1 | ERRFI1 | 0.683048 | 3 | 0 | 3 |
| PCMT1 | CYTH3 | 0.6816 | 3 | 0 | 3 |
| PCMT1 | IRAK4 | 0.68118 | 3 | 0 | 3 |
| PCMT1 | GHITM | 0.679601 | 4 | 0 | 4 |
| PCMT1 | ARL16 | 0.678984 | 4 | 0 | 4 |
| PCMT1 | CCNJ | 0.678952 | 4 | 0 | 3 |
| PCMT1 | DNAJA1 | 0.678172 | 4 | 0 | 3 |
| PCMT1 | SCOC | 0.675229 | 3 | 0 | 3 |
| PCMT1 | VPS29 | 0.675089 | 5 | 0 | 4 |
| PCMT1 | AKIRIN1 | 0.674821 | 4 | 0 | 3 |
For details and further investigation, click here
