| Full name: interleukin 1 receptor associated kinase 4 | Alias Symbol: NY-REN-64 | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 51135 | HGNC ID: HGNC:17967 | Ensembl Gene: ENSG00000198001 | OMIM ID: 606883 |
| Drug and gene relationship at DGIdb | |||
IRAK4 involved pathways:
Expression of IRAK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRAK4 | 51135 | 219618_at | -0.6205 | 0.1171 | |
| GSE20347 | IRAK4 | 51135 | 219618_at | -0.4878 | 0.0006 | |
| GSE23400 | IRAK4 | 51135 | 219618_at | -0.1772 | 0.0010 | |
| GSE26886 | IRAK4 | 51135 | 219618_at | -0.6176 | 0.0007 | |
| GSE29001 | IRAK4 | 51135 | 219618_at | -0.6072 | 0.0613 | |
| GSE38129 | IRAK4 | 51135 | 219618_at | -0.2904 | 0.1024 | |
| GSE45670 | IRAK4 | 51135 | 219618_at | -0.2157 | 0.1808 | |
| GSE53622 | IRAK4 | 51135 | 47568 | -0.4881 | 0.0000 | |
| GSE53624 | IRAK4 | 51135 | 47568 | -0.9181 | 0.0000 | |
| GSE63941 | IRAK4 | 51135 | 219618_at | -0.4047 | 0.3363 | |
| GSE77861 | IRAK4 | 51135 | 219618_at | -0.0095 | 0.9767 | |
| GSE97050 | IRAK4 | 51135 | A_24_P158903 | 0.1763 | 0.7076 | |
| SRP007169 | IRAK4 | 51135 | RNAseq | -0.9210 | 0.0135 | |
| SRP008496 | IRAK4 | 51135 | RNAseq | -1.0780 | 0.0001 | |
| SRP064894 | IRAK4 | 51135 | RNAseq | -0.7295 | 0.0000 | |
| SRP133303 | IRAK4 | 51135 | RNAseq | -0.1550 | 0.3606 | |
| SRP159526 | IRAK4 | 51135 | RNAseq | -0.9131 | 0.0001 | |
| SRP193095 | IRAK4 | 51135 | RNAseq | -0.7610 | 0.0000 | |
| SRP219564 | IRAK4 | 51135 | RNAseq | -0.4950 | 0.1305 | |
| TCGA | IRAK4 | 51135 | RNAseq | -0.1792 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by IRAK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRAK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRAK4 | 51135 | 4 | 1 | 25 | |
| GSE20123 | IRAK4 | 51135 | 4 | 1 | 25 | |
| GSE43470 | IRAK4 | 51135 | 3 | 3 | 37 | |
| GSE46452 | IRAK4 | 51135 | 8 | 1 | 50 | |
| GSE47630 | IRAK4 | 51135 | 11 | 2 | 27 | |
| GSE54993 | IRAK4 | 51135 | 0 | 6 | 64 | |
| GSE54994 | IRAK4 | 51135 | 7 | 1 | 45 | |
| GSE60625 | IRAK4 | 51135 | 0 | 0 | 11 | |
| GSE74703 | IRAK4 | 51135 | 3 | 2 | 31 | |
| GSE74704 | IRAK4 | 51135 | 2 | 1 | 17 | |
| TCGA | IRAK4 | 51135 | 16 | 13 | 67 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of IRAK4:
Generating mutation plots.
Highly correlated genes for IRAK4:
Showing top 20/1322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRAK4 | SCFD1 | 0.778183 | 3 | 0 | 3 |
| IRAK4 | RBM20 | 0.766111 | 3 | 0 | 3 |
| IRAK4 | ZNF217 | 0.753429 | 3 | 0 | 3 |
| IRAK4 | KDM3A | 0.742025 | 4 | 0 | 4 |
| IRAK4 | ELOVL1 | 0.739016 | 3 | 0 | 3 |
| IRAK4 | AP3M1 | 0.731149 | 3 | 0 | 3 |
| IRAK4 | ULK3 | 0.728689 | 6 | 0 | 6 |
| IRAK4 | EXOC4 | 0.728321 | 3 | 0 | 3 |
| IRAK4 | KPNA3 | 0.726969 | 3 | 0 | 3 |
| IRAK4 | ARHGAP27 | 0.721724 | 6 | 0 | 6 |
| IRAK4 | C15orf62 | 0.720683 | 6 | 0 | 6 |
| IRAK4 | NUAK2 | 0.71748 | 3 | 0 | 3 |
| IRAK4 | FAM214A | 0.716509 | 6 | 0 | 6 |
| IRAK4 | ZNF268 | 0.715958 | 3 | 0 | 3 |
| IRAK4 | PLEKHA7 | 0.714802 | 6 | 0 | 6 |
| IRAK4 | ZNF823 | 0.713307 | 6 | 0 | 5 |
| IRAK4 | FAM3B | 0.713176 | 5 | 0 | 4 |
| IRAK4 | TWF1 | 0.711489 | 12 | 0 | 11 |
| IRAK4 | KLHDC2 | 0.708814 | 3 | 0 | 3 |
| IRAK4 | DCTD | 0.707855 | 3 | 0 | 3 |
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