| Full name: phosphodiesterase 8B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 8622 | HGNC ID: HGNC:8794 | Ensembl Gene: ENSG00000113231 | OMIM ID: 603390 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE8B | 8622 | 213228_at | -0.6847 | 0.1136 | |
| GSE20347 | PDE8B | 8622 | 213228_at | -0.0178 | 0.8859 | |
| GSE23400 | PDE8B | 8622 | 213228_at | -0.1772 | 0.0000 | |
| GSE26886 | PDE8B | 8622 | 213228_at | 0.1398 | 0.2883 | |
| GSE29001 | PDE8B | 8622 | 213228_at | 0.0247 | 0.9142 | |
| GSE38129 | PDE8B | 8622 | 213228_at | -0.4398 | 0.0008 | |
| GSE45670 | PDE8B | 8622 | 213228_at | -0.5741 | 0.0007 | |
| GSE53622 | PDE8B | 8622 | 15060 | -0.7051 | 0.0000 | |
| GSE53624 | PDE8B | 8622 | 15060 | -0.5112 | 0.0000 | |
| GSE63941 | PDE8B | 8622 | 213228_at | 0.1657 | 0.8068 | |
| GSE77861 | PDE8B | 8622 | 213228_at | 0.1978 | 0.1991 | |
| GSE97050 | PDE8B | 8622 | A_24_P197537 | -0.2511 | 0.2736 | |
| SRP007169 | PDE8B | 8622 | RNAseq | -0.0307 | 0.9616 | |
| SRP064894 | PDE8B | 8622 | RNAseq | -1.5097 | 0.0000 | |
| SRP133303 | PDE8B | 8622 | RNAseq | -0.5274 | 0.0975 | |
| SRP159526 | PDE8B | 8622 | RNAseq | -0.8146 | 0.0221 | |
| SRP193095 | PDE8B | 8622 | RNAseq | -0.4516 | 0.0008 | |
| SRP219564 | PDE8B | 8622 | RNAseq | -0.9113 | 0.0345 | |
| TCGA | PDE8B | 8622 | RNAseq | -1.3934 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PDE8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE8B | 8622 | 1 | 13 | 16 | |
| GSE20123 | PDE8B | 8622 | 1 | 13 | 16 | |
| GSE43470 | PDE8B | 8622 | 1 | 13 | 29 | |
| GSE46452 | PDE8B | 8622 | 0 | 28 | 31 | |
| GSE47630 | PDE8B | 8622 | 1 | 19 | 20 | |
| GSE54993 | PDE8B | 8622 | 8 | 1 | 61 | |
| GSE54994 | PDE8B | 8622 | 1 | 19 | 33 | |
| GSE60625 | PDE8B | 8622 | 0 | 0 | 11 | |
| GSE74703 | PDE8B | 8622 | 1 | 9 | 26 | |
| GSE74704 | PDE8B | 8622 | 1 | 6 | 13 | |
| TCGA | PDE8B | 8622 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of PDE8B:
Generating mutation plots.
Highly correlated genes for PDE8B:
Showing top 20/467 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE8B | ZNF548 | 0.754986 | 3 | 0 | 3 |
| PDE8B | ZMIZ1 | 0.754776 | 3 | 0 | 3 |
| PDE8B | AADAT | 0.732688 | 3 | 0 | 3 |
| PDE8B | VAMP1 | 0.721136 | 3 | 0 | 3 |
| PDE8B | C14orf28 | 0.71985 | 3 | 0 | 3 |
| PDE8B | TLN2 | 0.710104 | 3 | 0 | 3 |
| PDE8B | PCDH18 | 0.705357 | 4 | 0 | 4 |
| PDE8B | LIN52 | 0.705247 | 3 | 0 | 3 |
| PDE8B | MIF4GD | 0.6975 | 3 | 0 | 3 |
| PDE8B | MSRB3 | 0.692686 | 3 | 0 | 3 |
| PDE8B | CNRIP1 | 0.680587 | 3 | 0 | 3 |
| PDE8B | TRAF5 | 0.677998 | 3 | 0 | 3 |
| PDE8B | TEX9 | 0.670106 | 5 | 0 | 5 |
| PDE8B | C22orf31 | 0.67 | 3 | 0 | 3 |
| PDE8B | FILIP1 | 0.66856 | 3 | 0 | 3 |
| PDE8B | IGSF10 | 0.665591 | 5 | 0 | 3 |
| PDE8B | GDPD1 | 0.664454 | 4 | 0 | 3 |
| PDE8B | ZBED1 | 0.664272 | 3 | 0 | 3 |
| PDE8B | RECQL5 | 0.663751 | 4 | 0 | 3 |
| PDE8B | CABIN1 | 0.663119 | 3 | 0 | 3 |
For details and further investigation, click here
