| Full name: lin-52 DREAM MuvB core complex component | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 91750 | HGNC ID: HGNC:19856 | Ensembl Gene: ENSG00000205659 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LIN52:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN52 | 91750 | 231959_at | 0.1562 | 0.7372 | |
| GSE26886 | LIN52 | 91750 | 228583_at | 0.2363 | 0.2849 | |
| GSE45670 | LIN52 | 91750 | 228583_at | 0.4280 | 0.0084 | |
| GSE53622 | LIN52 | 91750 | 36905 | 0.6446 | 0.0000 | |
| GSE53624 | LIN52 | 91750 | 36905 | 0.7050 | 0.0000 | |
| GSE63941 | LIN52 | 91750 | 231959_at | 0.7611 | 0.0098 | |
| GSE77861 | LIN52 | 91750 | 228583_at | 0.5629 | 0.0102 | |
| GSE97050 | LIN52 | 91750 | A_23_P339309 | 0.0479 | 0.8661 | |
| SRP007169 | LIN52 | 91750 | RNAseq | 1.6708 | 0.0001 | |
| SRP008496 | LIN52 | 91750 | RNAseq | 1.8123 | 0.0000 | |
| SRP064894 | LIN52 | 91750 | RNAseq | 0.7250 | 0.0000 | |
| SRP133303 | LIN52 | 91750 | RNAseq | 0.5541 | 0.0000 | |
| SRP159526 | LIN52 | 91750 | RNAseq | 0.6754 | 0.0062 | |
| SRP193095 | LIN52 | 91750 | RNAseq | 0.4872 | 0.0000 | |
| SRP219564 | LIN52 | 91750 | RNAseq | 0.6526 | 0.0325 | |
| TCGA | LIN52 | 91750 | RNAseq | 0.1271 | 0.1351 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LIN52 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIN52:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN52 | 91750 | 8 | 2 | 20 | |
| GSE20123 | LIN52 | 91750 | 8 | 2 | 20 | |
| GSE43470 | LIN52 | 91750 | 8 | 3 | 32 | |
| GSE46452 | LIN52 | 91750 | 16 | 3 | 40 | |
| GSE47630 | LIN52 | 91750 | 11 | 8 | 21 | |
| GSE54993 | LIN52 | 91750 | 3 | 8 | 59 | |
| GSE54994 | LIN52 | 91750 | 19 | 4 | 30 | |
| GSE60625 | LIN52 | 91750 | 0 | 2 | 9 | |
| GSE74703 | LIN52 | 91750 | 7 | 3 | 26 | |
| GSE74704 | LIN52 | 91750 | 3 | 2 | 15 | |
| TCGA | LIN52 | 91750 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 53; Total Number of normals: 320.
Somatic mutations of LIN52:
Generating mutation plots.
Highly correlated genes for LIN52:
Showing top 20/773 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN52 | RPS21 | 0.806254 | 3 | 0 | 3 |
| LIN52 | NDUFV1 | 0.785378 | 3 | 0 | 3 |
| LIN52 | HNRNPUL2 | 0.761307 | 3 | 0 | 3 |
| LIN52 | PSMD3 | 0.755632 | 3 | 0 | 3 |
| LIN52 | GNAI1 | 0.731631 | 3 | 0 | 3 |
| LIN52 | ZFP90 | 0.730682 | 5 | 0 | 4 |
| LIN52 | ZFHX3 | 0.72745 | 3 | 0 | 3 |
| LIN52 | MTMR2 | 0.725385 | 3 | 0 | 3 |
| LIN52 | ARTN | 0.720944 | 4 | 0 | 4 |
| LIN52 | PLXNA1 | 0.717967 | 4 | 0 | 4 |
| LIN52 | CDC37 | 0.717707 | 3 | 0 | 3 |
| LIN52 | CCT5 | 0.716183 | 5 | 0 | 5 |
| LIN52 | RAB13 | 0.715094 | 4 | 0 | 4 |
| LIN52 | LRRC47 | 0.712293 | 3 | 0 | 3 |
| LIN52 | DYNC2H1 | 0.711833 | 4 | 0 | 4 |
| LIN52 | PDE8B | 0.705247 | 3 | 0 | 3 |
| LIN52 | TMEM138 | 0.698848 | 5 | 0 | 5 |
| LIN52 | PPP1R21 | 0.698702 | 4 | 0 | 4 |
| LIN52 | ZC3H18 | 0.698323 | 3 | 0 | 3 |
| LIN52 | CCDC18 | 0.696586 | 4 | 0 | 4 |
For details and further investigation, click here
