| Full name: aminoadipate aminotransferase | Alias Symbol: KATII|KAT2|KYAT2 | ||
| Type: protein-coding gene | Cytoband: 4q33 | ||
| Entrez ID: 51166 | HGNC ID: HGNC:17929 | Ensembl Gene: ENSG00000109576 | OMIM ID: 611754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AADAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AADAT | 51166 | 223593_at | -0.0662 | 0.9394 | |
| GSE26886 | AADAT | 51166 | 223593_at | 0.0827 | 0.5801 | |
| GSE45670 | AADAT | 51166 | 223593_at | -0.5589 | 0.0020 | |
| GSE53622 | AADAT | 51166 | 119662 | 0.0049 | 0.9747 | |
| GSE53624 | AADAT | 51166 | 119662 | 0.0872 | 0.4479 | |
| GSE63941 | AADAT | 51166 | 223593_at | -1.0706 | 0.1032 | |
| GSE77861 | AADAT | 51166 | 223593_at | 0.1382 | 0.3466 | |
| GSE97050 | AADAT | 51166 | A_23_P253484 | 0.1437 | 0.6647 | |
| SRP007169 | AADAT | 51166 | RNAseq | 0.7969 | 0.2066 | |
| SRP008496 | AADAT | 51166 | RNAseq | 1.6771 | 0.0052 | |
| SRP064894 | AADAT | 51166 | RNAseq | -0.0125 | 0.9549 | |
| SRP133303 | AADAT | 51166 | RNAseq | 0.3812 | 0.1720 | |
| SRP159526 | AADAT | 51166 | RNAseq | 0.7235 | 0.1135 | |
| SRP193095 | AADAT | 51166 | RNAseq | 0.0468 | 0.7919 | |
| SRP219564 | AADAT | 51166 | RNAseq | -0.3734 | 0.3106 | |
| TCGA | AADAT | 51166 | RNAseq | -0.0601 | 0.7452 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AADAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AADAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AADAT | 51166 | 2 | 11 | 17 | |
| GSE20123 | AADAT | 51166 | 2 | 11 | 17 | |
| GSE43470 | AADAT | 51166 | 0 | 13 | 30 | |
| GSE46452 | AADAT | 51166 | 1 | 36 | 22 | |
| GSE47630 | AADAT | 51166 | 0 | 22 | 18 | |
| GSE54993 | AADAT | 51166 | 10 | 0 | 60 | |
| GSE54994 | AADAT | 51166 | 2 | 12 | 39 | |
| GSE60625 | AADAT | 51166 | 0 | 0 | 11 | |
| GSE74703 | AADAT | 51166 | 0 | 11 | 25 | |
| GSE74704 | AADAT | 51166 | 1 | 5 | 14 | |
| TCGA | AADAT | 51166 | 11 | 35 | 50 |
Total number of gains: 29; Total number of losses: 156; Total Number of normals: 303.
Somatic mutations of AADAT:
Generating mutation plots.
Highly correlated genes for AADAT:
Showing top 20/280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AADAT | ZNF260 | 0.743346 | 3 | 0 | 3 |
| AADAT | EMILIN2 | 0.742497 | 3 | 0 | 3 |
| AADAT | PDE8B | 0.732688 | 3 | 0 | 3 |
| AADAT | RPS19BP1 | 0.731395 | 3 | 0 | 3 |
| AADAT | REV3L | 0.72557 | 3 | 0 | 3 |
| AADAT | RPGR | 0.725255 | 3 | 0 | 3 |
| AADAT | DHX40 | 0.722162 | 3 | 0 | 3 |
| AADAT | DHRSX | 0.709454 | 3 | 0 | 3 |
| AADAT | NHS | 0.708261 | 4 | 0 | 4 |
| AADAT | SLC7A6 | 0.70165 | 3 | 0 | 3 |
| AADAT | P4HTM | 0.698639 | 3 | 0 | 3 |
| AADAT | CBX5 | 0.697782 | 3 | 0 | 3 |
| AADAT | PRKCA | 0.695136 | 3 | 0 | 3 |
| AADAT | PSEN2 | 0.693445 | 3 | 0 | 3 |
| AADAT | IFT52 | 0.686494 | 3 | 0 | 3 |
| AADAT | TUBGCP4 | 0.681164 | 3 | 0 | 3 |
| AADAT | PKIG | 0.679195 | 5 | 0 | 5 |
| AADAT | PARM1 | 0.678117 | 4 | 0 | 4 |
| AADAT | RNF24 | 0.67673 | 3 | 0 | 3 |
| AADAT | POU2F1 | 0.666596 | 3 | 0 | 3 |
For details and further investigation, click here
