| Full name: proteasome 26S subunit, ATPase 6 | Alias Symbol: p42 | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 5706 | HGNC ID: HGNC:9553 | Ensembl Gene: ENSG00000100519 | OMIM ID: 602708 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMC6 | 5706 | 201699_at | 0.1613 | 0.7886 | |
| GSE20347 | PSMC6 | 5706 | 201699_at | -0.1281 | 0.4691 | |
| GSE23400 | PSMC6 | 5706 | 201699_at | -0.0102 | 0.9325 | |
| GSE26886 | PSMC6 | 5706 | 201699_at | -0.8049 | 0.0000 | |
| GSE29001 | PSMC6 | 5706 | 201699_at | -0.1352 | 0.6372 | |
| GSE38129 | PSMC6 | 5706 | 201699_at | 0.0984 | 0.5059 | |
| GSE45670 | PSMC6 | 5706 | 201699_at | 0.1647 | 0.1636 | |
| GSE53622 | PSMC6 | 5706 | 13710 | -0.1532 | 0.0412 | |
| GSE53624 | PSMC6 | 5706 | 13710 | -0.2924 | 0.0000 | |
| GSE63941 | PSMC6 | 5706 | 201699_at | 0.1106 | 0.7371 | |
| GSE77861 | PSMC6 | 5706 | 201699_at | -0.1634 | 0.7455 | |
| GSE97050 | PSMC6 | 5706 | A_23_P128930 | 0.1948 | 0.4144 | |
| SRP007169 | PSMC6 | 5706 | RNAseq | -1.5185 | 0.0003 | |
| SRP008496 | PSMC6 | 5706 | RNAseq | -1.5514 | 0.0000 | |
| SRP064894 | PSMC6 | 5706 | RNAseq | -0.4836 | 0.0115 | |
| SRP133303 | PSMC6 | 5706 | RNAseq | 0.0121 | 0.9475 | |
| SRP159526 | PSMC6 | 5706 | RNAseq | -0.5122 | 0.0300 | |
| SRP193095 | PSMC6 | 5706 | RNAseq | -0.7708 | 0.0001 | |
| SRP219564 | PSMC6 | 5706 | RNAseq | 0.0038 | 0.9930 | |
| TCGA | PSMC6 | 5706 | RNAseq | 0.1113 | 0.0273 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PSMC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMC6 | 5706 | 8 | 3 | 19 | |
| GSE20123 | PSMC6 | 5706 | 8 | 3 | 19 | |
| GSE43470 | PSMC6 | 5706 | 9 | 1 | 33 | |
| GSE46452 | PSMC6 | 5706 | 16 | 3 | 40 | |
| GSE47630 | PSMC6 | 5706 | 11 | 10 | 19 | |
| GSE54993 | PSMC6 | 5706 | 3 | 8 | 59 | |
| GSE54994 | PSMC6 | 5706 | 19 | 4 | 30 | |
| GSE60625 | PSMC6 | 5706 | 0 | 2 | 9 | |
| GSE74703 | PSMC6 | 5706 | 8 | 1 | 27 | |
| GSE74704 | PSMC6 | 5706 | 3 | 2 | 15 | |
| TCGA | PSMC6 | 5706 | 34 | 12 | 50 |
Total number of gains: 119; Total number of losses: 49; Total Number of normals: 320.
Somatic mutations of PSMC6:
Generating mutation plots.
Highly correlated genes for PSMC6:
Showing top 20/605 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMC6 | TMEM69 | 0.878694 | 3 | 0 | 3 |
| PSMC6 | SPIN4 | 0.82598 | 3 | 0 | 3 |
| PSMC6 | OXNAD1 | 0.783844 | 3 | 0 | 3 |
| PSMC6 | RALGPS2 | 0.779344 | 3 | 0 | 3 |
| PSMC6 | SMC3 | 0.762161 | 3 | 0 | 3 |
| PSMC6 | RRAGC | 0.758105 | 3 | 0 | 3 |
| PSMC6 | TRIAP1 | 0.750064 | 3 | 0 | 3 |
| PSMC6 | EPG5 | 0.743168 | 3 | 0 | 3 |
| PSMC6 | LAPTM4A | 0.742209 | 3 | 0 | 3 |
| PSMC6 | THAP2 | 0.738096 | 3 | 0 | 3 |
| PSMC6 | MIS18BP1 | 0.735227 | 3 | 0 | 3 |
| PSMC6 | IPMK | 0.730068 | 3 | 0 | 3 |
| PSMC6 | PFKFB2 | 0.727544 | 3 | 0 | 3 |
| PSMC6 | B3GNT7 | 0.723008 | 3 | 0 | 3 |
| PSMC6 | PRPF38B | 0.717561 | 3 | 0 | 3 |
| PSMC6 | BTF3L4 | 0.716495 | 4 | 0 | 3 |
| PSMC6 | MIS18A | 0.708091 | 3 | 0 | 3 |
| PSMC6 | KIF21A | 0.704597 | 3 | 0 | 3 |
| PSMC6 | ELOVL1 | 0.701736 | 3 | 0 | 3 |
| PSMC6 | TRAPPC6B | 0.699936 | 6 | 0 | 4 |
For details and further investigation, click here
