| Full name: ubiquitin conjugating enzyme E2 D2 | Alias Symbol: UbcH5B|UBC4 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 7322 | HGNC ID: HGNC:12475 | Ensembl Gene: ENSG00000131508 | OMIM ID: 602962 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
UBE2D2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05131 | Shigellosis |
Expression of UBE2D2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2D2 | 7322 | 201345_s_at | -0.4341 | 0.2842 | |
| GSE20347 | UBE2D2 | 7322 | 201345_s_at | -0.3225 | 0.1037 | |
| GSE23400 | UBE2D2 | 7322 | 201345_s_at | -0.1128 | 0.1550 | |
| GSE26886 | UBE2D2 | 7322 | 201343_at | -1.2163 | 0.0000 | |
| GSE29001 | UBE2D2 | 7322 | 201343_at | -0.0241 | 0.9090 | |
| GSE38129 | UBE2D2 | 7322 | 201345_s_at | -0.2605 | 0.0558 | |
| GSE45670 | UBE2D2 | 7322 | 201343_at | -0.1017 | 0.5432 | |
| GSE53622 | UBE2D2 | 7322 | 3127 | -0.2592 | 0.0014 | |
| GSE53624 | UBE2D2 | 7322 | 3127 | -0.1131 | 0.1000 | |
| GSE63941 | UBE2D2 | 7322 | 201345_s_at | 1.1783 | 0.0021 | |
| GSE77861 | UBE2D2 | 7322 | 201343_at | -0.4039 | 0.0901 | |
| GSE97050 | UBE2D2 | 7322 | A_33_P3310674 | -0.4475 | 0.1784 | |
| SRP007169 | UBE2D2 | 7322 | RNAseq | -1.3274 | 0.0004 | |
| SRP008496 | UBE2D2 | 7322 | RNAseq | -1.2931 | 0.0000 | |
| SRP064894 | UBE2D2 | 7322 | RNAseq | -0.2508 | 0.0404 | |
| SRP133303 | UBE2D2 | 7322 | RNAseq | 0.4196 | 0.1112 | |
| SRP159526 | UBE2D2 | 7322 | RNAseq | -0.2732 | 0.3930 | |
| SRP193095 | UBE2D2 | 7322 | RNAseq | -0.3691 | 0.0004 | |
| SRP219564 | UBE2D2 | 7322 | RNAseq | -0.3787 | 0.0691 | |
| TCGA | UBE2D2 | 7322 | RNAseq | 0.0491 | 0.2827 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by UBE2D2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE2D2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2D2 | 7322 | 3 | 11 | 16 | |
| GSE20123 | UBE2D2 | 7322 | 4 | 11 | 15 | |
| GSE43470 | UBE2D2 | 7322 | 4 | 8 | 31 | |
| GSE46452 | UBE2D2 | 7322 | 0 | 27 | 32 | |
| GSE47630 | UBE2D2 | 7322 | 0 | 20 | 20 | |
| GSE54993 | UBE2D2 | 7322 | 9 | 1 | 60 | |
| GSE54994 | UBE2D2 | 7322 | 2 | 14 | 37 | |
| GSE60625 | UBE2D2 | 7322 | 0 | 0 | 11 | |
| GSE74703 | UBE2D2 | 7322 | 3 | 6 | 27 | |
| GSE74704 | UBE2D2 | 7322 | 3 | 5 | 12 | |
| TCGA | UBE2D2 | 7322 | 4 | 37 | 55 |
Total number of gains: 32; Total number of losses: 140; Total Number of normals: 316.
Somatic mutations of UBE2D2:
Generating mutation plots.
Highly correlated genes for UBE2D2:
Showing top 20/828 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2D2 | PHKB | 0.805054 | 4 | 0 | 4 |
| UBE2D2 | NDUFA10 | 0.796539 | 3 | 0 | 3 |
| UBE2D2 | MBOAT2 | 0.788045 | 4 | 0 | 4 |
| UBE2D2 | GOLPH3L | 0.78198 | 3 | 0 | 3 |
| UBE2D2 | ESYT2 | 0.772876 | 4 | 0 | 4 |
| UBE2D2 | HMGN1 | 0.765559 | 3 | 0 | 3 |
| UBE2D2 | PTGR1 | 0.761782 | 4 | 0 | 4 |
| UBE2D2 | COMMD1 | 0.757303 | 3 | 0 | 3 |
| UBE2D2 | SLC16A14 | 0.755346 | 3 | 0 | 3 |
| UBE2D2 | UBQLN1 | 0.755046 | 3 | 0 | 3 |
| UBE2D2 | SEC24B | 0.754498 | 3 | 0 | 3 |
| UBE2D2 | HLF | 0.749875 | 3 | 0 | 3 |
| UBE2D2 | MOB4 | 0.749829 | 3 | 0 | 3 |
| UBE2D2 | P2RY13 | 0.74416 | 3 | 0 | 3 |
| UBE2D2 | MGAT4A | 0.737509 | 3 | 0 | 3 |
| UBE2D2 | HOXC5 | 0.731499 | 3 | 0 | 3 |
| UBE2D2 | CHMP5 | 0.730714 | 4 | 0 | 3 |
| UBE2D2 | ALKBH7 | 0.728595 | 4 | 0 | 3 |
| UBE2D2 | SLU7 | 0.727808 | 3 | 0 | 3 |
| UBE2D2 | ARSG | 0.717794 | 3 | 0 | 3 |
For details and further investigation, click here
