| Full name: tRNA splicing endonuclease subunit 34 | Alias Symbol: SEN34|SEN34L | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 79042 | HGNC ID: HGNC:15506 | Ensembl Gene: ENSG00000170892 | OMIM ID: 608754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TSEN34:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSEN34 | 79042 | 218132_s_at | 0.2859 | 0.1819 | |
| GSE20347 | TSEN34 | 79042 | 218132_s_at | 0.0477 | 0.7573 | |
| GSE23400 | TSEN34 | 79042 | 218132_s_at | 0.2205 | 0.0010 | |
| GSE26886 | TSEN34 | 79042 | 218132_s_at | 0.3344 | 0.0394 | |
| GSE29001 | TSEN34 | 79042 | 218132_s_at | 0.0145 | 0.9404 | |
| GSE38129 | TSEN34 | 79042 | 218132_s_at | 0.2238 | 0.0260 | |
| GSE45670 | TSEN34 | 79042 | 218132_s_at | 0.1088 | 0.3356 | |
| GSE53622 | TSEN34 | 79042 | 56354 | 0.0741 | 0.2442 | |
| GSE53624 | TSEN34 | 79042 | 56354 | 0.2743 | 0.0000 | |
| GSE63941 | TSEN34 | 79042 | 218132_s_at | 0.4044 | 0.3417 | |
| GSE77861 | TSEN34 | 79042 | 218132_s_at | -0.1061 | 0.5509 | |
| GSE97050 | TSEN34 | 79042 | A_33_P3211213 | -0.2474 | 0.2589 | |
| SRP007169 | TSEN34 | 79042 | RNAseq | -0.7900 | 0.0458 | |
| SRP008496 | TSEN34 | 79042 | RNAseq | -0.5320 | 0.0498 | |
| SRP064894 | TSEN34 | 79042 | RNAseq | 0.4685 | 0.1041 | |
| SRP133303 | TSEN34 | 79042 | RNAseq | 0.0740 | 0.6578 | |
| SRP159526 | TSEN34 | 79042 | RNAseq | 0.2783 | 0.1420 | |
| SRP193095 | TSEN34 | 79042 | RNAseq | 0.1336 | 0.3603 | |
| SRP219564 | TSEN34 | 79042 | RNAseq | -0.0084 | 0.9726 | |
| TCGA | TSEN34 | 79042 | RNAseq | 0.1769 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TSEN34 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSEN34:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSEN34 | 79042 | 3 | 4 | 23 | |
| GSE20123 | TSEN34 | 79042 | 3 | 3 | 24 | |
| GSE43470 | TSEN34 | 79042 | 2 | 11 | 30 | |
| GSE46452 | TSEN34 | 79042 | 45 | 1 | 13 | |
| GSE47630 | TSEN34 | 79042 | 8 | 6 | 26 | |
| GSE54993 | TSEN34 | 79042 | 17 | 4 | 49 | |
| GSE54994 | TSEN34 | 79042 | 4 | 13 | 36 | |
| GSE60625 | TSEN34 | 79042 | 9 | 0 | 2 | |
| GSE74703 | TSEN34 | 79042 | 2 | 7 | 27 | |
| GSE74704 | TSEN34 | 79042 | 3 | 1 | 16 | |
| TCGA | TSEN34 | 79042 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 65; Total Number of normals: 308.
Somatic mutations of TSEN34:
Generating mutation plots.
Highly correlated genes for TSEN34:
Showing top 20/452 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSEN34 | ZNF789 | 0.835666 | 3 | 0 | 3 |
| TSEN34 | BRD9 | 0.802052 | 3 | 0 | 3 |
| TSEN34 | HGS | 0.795334 | 3 | 0 | 3 |
| TSEN34 | ZNF672 | 0.791678 | 3 | 0 | 3 |
| TSEN34 | SGSH | 0.787566 | 3 | 0 | 3 |
| TSEN34 | DMAP1 | 0.76531 | 3 | 0 | 3 |
| TSEN34 | SDF4 | 0.757553 | 3 | 0 | 3 |
| TSEN34 | COMMD7 | 0.754143 | 3 | 0 | 3 |
| TSEN34 | ADCK1 | 0.750684 | 3 | 0 | 3 |
| TSEN34 | PFKL | 0.748699 | 3 | 0 | 3 |
| TSEN34 | ZNF445 | 0.741177 | 3 | 0 | 3 |
| TSEN34 | BRIX1 | 0.73547 | 3 | 0 | 3 |
| TSEN34 | SLC41A1 | 0.735029 | 3 | 0 | 3 |
| TSEN34 | POLH | 0.734249 | 3 | 0 | 3 |
| TSEN34 | PCYT1A | 0.734075 | 3 | 0 | 3 |
| TSEN34 | SSBP4 | 0.734016 | 4 | 0 | 3 |
| TSEN34 | TCF19 | 0.732473 | 3 | 0 | 3 |
| TSEN34 | ZNF683 | 0.731385 | 3 | 0 | 3 |
| TSEN34 | STK4 | 0.731373 | 3 | 0 | 3 |
| TSEN34 | SMARCC1 | 0.730671 | 4 | 0 | 3 |
For details and further investigation, click here
