| Full name: DNA polymerase nu | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 353497 | HGNC ID: HGNC:18870 | Ensembl Gene: ENSG00000130997 | OMIM ID: 610887 |
| Drug and gene relationship at DGIdb | |||
Expression of POLN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLN | 353497 | 242804_at | 0.0260 | 0.9363 | |
| GSE26886 | POLN | 353497 | 242804_at | -0.2521 | 0.0465 | |
| GSE45670 | POLN | 353497 | 233454_at | 0.1186 | 0.1086 | |
| GSE53622 | POLN | 353497 | 35397 | -0.4345 | 0.0054 | |
| GSE53624 | POLN | 353497 | 35397 | -0.7777 | 0.0000 | |
| GSE63941 | POLN | 353497 | 233454_at | 0.0010 | 0.9961 | |
| GSE77861 | POLN | 353497 | 242804_at | -0.1552 | 0.1559 | |
| GSE97050 | POLN | 353497 | A_32_P414791 | -0.0333 | 0.8933 | |
| SRP133303 | POLN | 353497 | RNAseq | -0.2323 | 0.2803 | |
| SRP159526 | POLN | 353497 | RNAseq | 0.3036 | 0.6935 | |
| SRP219564 | POLN | 353497 | RNAseq | -0.5200 | 0.2278 | |
| TCGA | POLN | 353497 | RNAseq | -0.4753 | 0.1148 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLN | 353497 | 0 | 16 | 14 | |
| GSE20123 | POLN | 353497 | 0 | 16 | 14 | |
| GSE43470 | POLN | 353497 | 0 | 17 | 26 | |
| GSE46452 | POLN | 353497 | 1 | 36 | 22 | |
| GSE47630 | POLN | 353497 | 1 | 19 | 20 | |
| GSE54993 | POLN | 353497 | 11 | 0 | 59 | |
| GSE54994 | POLN | 353497 | 3 | 12 | 38 | |
| GSE60625 | POLN | 353497 | 0 | 0 | 11 | |
| GSE74703 | POLN | 353497 | 0 | 13 | 23 | |
| GSE74704 | POLN | 353497 | 0 | 8 | 12 | |
| TCGA | POLN | 353497 | 9 | 47 | 40 |
Total number of gains: 25; Total number of losses: 184; Total Number of normals: 279.
Somatic mutations of POLN:
Generating mutation plots.
Highly correlated genes for POLN:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLN | PPP2R1A | 0.777327 | 3 | 0 | 3 |
| POLN | PFKL | 0.766454 | 3 | 0 | 3 |
| POLN | GRN | 0.743844 | 3 | 0 | 3 |
| POLN | FOXP4 | 0.738404 | 3 | 0 | 3 |
| POLN | DNAH11 | 0.733089 | 3 | 0 | 3 |
| POLN | FLYWCH2 | 0.726329 | 3 | 0 | 3 |
| POLN | LILRA2 | 0.719311 | 3 | 0 | 3 |
| POLN | KLRC3 | 0.718372 | 3 | 0 | 3 |
| POLN | DCXR | 0.717439 | 3 | 0 | 3 |
| POLN | ABLIM2 | 0.716308 | 3 | 0 | 3 |
| POLN | TMEM114 | 0.708451 | 3 | 0 | 3 |
| POLN | ZNF625 | 0.705715 | 3 | 0 | 3 |
| POLN | TNFRSF8 | 0.705393 | 3 | 0 | 3 |
| POLN | PRLR | 0.697156 | 3 | 0 | 3 |
| POLN | CDK9 | 0.695229 | 3 | 0 | 3 |
| POLN | ZNF552 | 0.69424 | 3 | 0 | 3 |
| POLN | UNC5B | 0.678256 | 3 | 0 | 3 |
| POLN | CLDN2 | 0.677361 | 4 | 0 | 4 |
| POLN | RABAC1 | 0.673408 | 3 | 0 | 3 |
| POLN | COPZ1 | 0.669654 | 3 | 0 | 3 |
For details and further investigation, click here
