| Full name: TNF receptor associated factor 4 | Alias Symbol: CART1|MLN62|RNF83 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 9618 | HGNC ID: HGNC:12034 | Ensembl Gene: ENSG00000076604 | OMIM ID: 602464 |
| Drug and gene relationship at DGIdb | |||
TRAF4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of TRAF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRAF4 | 9618 | 202871_at | 1.3711 | 0.0534 | |
| GSE20347 | TRAF4 | 9618 | 202871_at | 0.3238 | 0.1206 | |
| GSE23400 | TRAF4 | 9618 | 211899_s_at | 0.0305 | 0.6795 | |
| GSE26886 | TRAF4 | 9618 | 202871_at | 1.1556 | 0.0001 | |
| GSE29001 | TRAF4 | 9618 | 202871_at | 0.0692 | 0.8737 | |
| GSE38129 | TRAF4 | 9618 | 202871_at | 0.7396 | 0.0003 | |
| GSE45670 | TRAF4 | 9618 | 202871_at | 0.5692 | 0.0122 | |
| GSE53622 | TRAF4 | 9618 | 130957 | 0.4105 | 0.0000 | |
| GSE53624 | TRAF4 | 9618 | 130957 | 0.1130 | 0.1277 | |
| GSE63941 | TRAF4 | 9618 | 202871_at | 1.0585 | 0.0612 | |
| GSE77861 | TRAF4 | 9618 | 202871_at | 0.7352 | 0.0155 | |
| GSE97050 | TRAF4 | 9618 | A_23_P15654 | 0.2901 | 0.5867 | |
| SRP007169 | TRAF4 | 9618 | RNAseq | -0.9672 | 0.0974 | |
| SRP008496 | TRAF4 | 9618 | RNAseq | -0.7122 | 0.0242 | |
| SRP064894 | TRAF4 | 9618 | RNAseq | -0.1924 | 0.4375 | |
| SRP133303 | TRAF4 | 9618 | RNAseq | 0.3935 | 0.0401 | |
| SRP159526 | TRAF4 | 9618 | RNAseq | 0.9437 | 0.0636 | |
| SRP193095 | TRAF4 | 9618 | RNAseq | 0.1100 | 0.5186 | |
| SRP219564 | TRAF4 | 9618 | RNAseq | 0.1107 | 0.8310 | |
| TCGA | TRAF4 | 9618 | RNAseq | 0.1108 | 0.0803 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TRAF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRAF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRAF4 | 9618 | 9 | 1 | 20 | |
| GSE20123 | TRAF4 | 9618 | 9 | 1 | 20 | |
| GSE43470 | TRAF4 | 9618 | 0 | 1 | 42 | |
| GSE46452 | TRAF4 | 9618 | 33 | 1 | 25 | |
| GSE47630 | TRAF4 | 9618 | 7 | 1 | 32 | |
| GSE54993 | TRAF4 | 9618 | 2 | 3 | 65 | |
| GSE54994 | TRAF4 | 9618 | 7 | 6 | 40 | |
| GSE60625 | TRAF4 | 9618 | 4 | 0 | 7 | |
| GSE74703 | TRAF4 | 9618 | 0 | 1 | 35 | |
| GSE74704 | TRAF4 | 9618 | 7 | 1 | 12 | |
| TCGA | TRAF4 | 9618 | 21 | 10 | 65 |
Total number of gains: 99; Total number of losses: 26; Total Number of normals: 363.
Somatic mutations of TRAF4:
Generating mutation plots.
Highly correlated genes for TRAF4:
Showing top 20/962 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRAF4 | PHF12 | 0.742519 | 5 | 0 | 5 |
| TRAF4 | ZNF680 | 0.741548 | 3 | 0 | 3 |
| TRAF4 | YWHAG | 0.712105 | 3 | 0 | 3 |
| TRAF4 | BLM | 0.705818 | 6 | 0 | 6 |
| TRAF4 | DHRS13 | 0.70341 | 6 | 0 | 6 |
| TRAF4 | FOXE1 | 0.702075 | 4 | 0 | 4 |
| TRAF4 | HAS3 | 0.69753 | 3 | 0 | 3 |
| TRAF4 | LIN9 | 0.69404 | 6 | 0 | 6 |
| TRAF4 | ZSCAN29 | 0.688373 | 3 | 0 | 3 |
| TRAF4 | NOP2 | 0.68706 | 7 | 0 | 5 |
| TRAF4 | MRPS12 | 0.678631 | 7 | 0 | 7 |
| TRAF4 | CCDC34 | 0.677156 | 4 | 0 | 4 |
| TRAF4 | RNASEH1-AS1 | 0.676069 | 3 | 0 | 3 |
| TRAF4 | FLVCR1 | 0.673088 | 6 | 0 | 6 |
| TRAF4 | ZNF670 | 0.672919 | 5 | 0 | 5 |
| TRAF4 | TRAF2 | 0.666712 | 4 | 0 | 4 |
| TRAF4 | ACBD6 | 0.666497 | 5 | 0 | 4 |
| TRAF4 | TSEN15 | 0.661753 | 4 | 0 | 4 |
| TRAF4 | ANKRD23 | 0.661032 | 4 | 0 | 4 |
| TRAF4 | KDM1B | 0.65776 | 4 | 0 | 3 |
For details and further investigation, click here
