| Full name: PH domain and leucine rich repeat protein phosphatase 2 | Alias Symbol: KIAA0931|PPM3B | ||
| Type: protein-coding gene | Cytoband: 16q22.2 | ||
| Entrez ID: 23035 | HGNC ID: HGNC:29149 | Ensembl Gene: ENSG00000040199 | OMIM ID: 611066 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PHLPP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of PHLPP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLPP2 | 23035 | 213407_at | 0.1725 | 0.7517 | |
| GSE20347 | PHLPP2 | 23035 | 213407_at | 0.3524 | 0.0006 | |
| GSE23400 | PHLPP2 | 23035 | 214944_at | -0.2274 | 0.0000 | |
| GSE26886 | PHLPP2 | 23035 | 213407_at | 0.4837 | 0.0235 | |
| GSE29001 | PHLPP2 | 23035 | 213407_at | 0.4073 | 0.0144 | |
| GSE38129 | PHLPP2 | 23035 | 213407_at | 0.1130 | 0.5168 | |
| GSE45670 | PHLPP2 | 23035 | 213407_at | -0.2365 | 0.2060 | |
| GSE53622 | PHLPP2 | 23035 | 87698 | 0.2873 | 0.0470 | |
| GSE53624 | PHLPP2 | 23035 | 87698 | -0.2981 | 0.0081 | |
| GSE63941 | PHLPP2 | 23035 | 213407_at | -1.0975 | 0.0096 | |
| GSE77861 | PHLPP2 | 23035 | 213407_at | -0.0712 | 0.5296 | |
| GSE97050 | PHLPP2 | 23035 | A_33_P3271810 | -0.3661 | 0.1579 | |
| SRP007169 | PHLPP2 | 23035 | RNAseq | 1.3815 | 0.0008 | |
| SRP008496 | PHLPP2 | 23035 | RNAseq | 1.4289 | 0.0000 | |
| SRP064894 | PHLPP2 | 23035 | RNAseq | 0.2105 | 0.4398 | |
| SRP133303 | PHLPP2 | 23035 | RNAseq | 0.5830 | 0.0005 | |
| SRP159526 | PHLPP2 | 23035 | RNAseq | 0.5656 | 0.1057 | |
| SRP193095 | PHLPP2 | 23035 | RNAseq | 0.6533 | 0.0021 | |
| SRP219564 | PHLPP2 | 23035 | RNAseq | 0.2386 | 0.6037 | |
| TCGA | PHLPP2 | 23035 | RNAseq | -0.1384 | 0.0865 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by PHLPP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLPP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLPP2 | 23035 | 4 | 0 | 26 | |
| GSE20123 | PHLPP2 | 23035 | 4 | 0 | 26 | |
| GSE43470 | PHLPP2 | 23035 | 2 | 8 | 33 | |
| GSE46452 | PHLPP2 | 23035 | 38 | 2 | 19 | |
| GSE47630 | PHLPP2 | 23035 | 11 | 8 | 21 | |
| GSE54993 | PHLPP2 | 23035 | 2 | 4 | 64 | |
| GSE54994 | PHLPP2 | 23035 | 8 | 10 | 35 | |
| GSE60625 | PHLPP2 | 23035 | 4 | 0 | 7 | |
| GSE74703 | PHLPP2 | 23035 | 2 | 5 | 29 | |
| GSE74704 | PHLPP2 | 23035 | 2 | 0 | 18 | |
| TCGA | PHLPP2 | 23035 | 28 | 12 | 56 |
Total number of gains: 105; Total number of losses: 49; Total Number of normals: 334.
Somatic mutations of PHLPP2:
Generating mutation plots.
Highly correlated genes for PHLPP2:
Showing top 20/303 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLPP2 | KRTAP10-12 | 0.75159 | 3 | 0 | 3 |
| PHLPP2 | USP2-AS1 | 0.703161 | 3 | 0 | 3 |
| PHLPP2 | COX6A2 | 0.702306 | 4 | 0 | 4 |
| PHLPP2 | GPX5 | 0.677236 | 3 | 0 | 3 |
| PHLPP2 | GPR137C | 0.673842 | 3 | 0 | 3 |
| PHLPP2 | MCAM | 0.671881 | 6 | 0 | 5 |
| PHLPP2 | YPEL4 | 0.671547 | 3 | 0 | 3 |
| PHLPP2 | KRTAP10-8 | 0.668202 | 3 | 0 | 3 |
| PHLPP2 | CHRM2 | 0.664658 | 3 | 0 | 3 |
| PHLPP2 | PYGB | 0.661263 | 3 | 0 | 3 |
| PHLPP2 | GRM1 | 0.661148 | 5 | 0 | 4 |
| PHLPP2 | SHC3 | 0.66097 | 3 | 0 | 3 |
| PHLPP2 | KCNJ9 | 0.659139 | 5 | 0 | 4 |
| PHLPP2 | EHD2 | 0.655113 | 3 | 0 | 3 |
| PHLPP2 | FAM229B | 0.654752 | 3 | 0 | 3 |
| PHLPP2 | OR10AD1 | 0.651472 | 3 | 0 | 3 |
| PHLPP2 | SYCE1 | 0.647162 | 4 | 0 | 4 |
| PHLPP2 | STRC | 0.645782 | 3 | 0 | 3 |
| PHLPP2 | DCDC1 | 0.641907 | 3 | 0 | 3 |
| PHLPP2 | DIXDC1 | 0.639499 | 4 | 0 | 4 |
For details and further investigation, click here
