| Full name: paired like homeodomain 2 | Alias Symbol: IGDS|RS|Brx1|Otlx2|ARP1 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 5308 | HGNC ID: HGNC:9005 | Ensembl Gene: ENSG00000164093 | OMIM ID: 601542 |
| Drug and gene relationship at DGIdb | |||
Expression of PITX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PITX2 | 5308 | 207558_s_at | 2.0105 | 0.0353 | |
| GSE20347 | PITX2 | 5308 | 207558_s_at | 1.3218 | 0.0003 | |
| GSE23400 | PITX2 | 5308 | 207558_s_at | 0.1028 | 0.0452 | |
| GSE26886 | PITX2 | 5308 | 207558_s_at | 2.7631 | 0.0000 | |
| GSE29001 | PITX2 | 5308 | 207558_s_at | 0.8118 | 0.0229 | |
| GSE38129 | PITX2 | 5308 | 207558_s_at | 1.3227 | 0.0001 | |
| GSE45670 | PITX2 | 5308 | 207558_s_at | 0.9116 | 0.0392 | |
| GSE53622 | PITX2 | 5308 | 72118 | 0.7254 | 0.0000 | |
| GSE53624 | PITX2 | 5308 | 72118 | 0.9259 | 0.0000 | |
| GSE63941 | PITX2 | 5308 | 207558_s_at | -1.9098 | 0.0879 | |
| GSE77861 | PITX2 | 5308 | 207558_s_at | 0.4227 | 0.4060 | |
| GSE97050 | PITX2 | 5308 | A_23_P167367 | -0.1788 | 0.7070 | |
| SRP007169 | PITX2 | 5308 | RNAseq | 0.9545 | 0.1346 | |
| SRP008496 | PITX2 | 5308 | RNAseq | -0.0486 | 0.9231 | |
| SRP064894 | PITX2 | 5308 | RNAseq | 1.4325 | 0.0000 | |
| SRP133303 | PITX2 | 5308 | RNAseq | 1.8979 | 0.0000 | |
| SRP159526 | PITX2 | 5308 | RNAseq | 1.3299 | 0.0001 | |
| SRP219564 | PITX2 | 5308 | RNAseq | 0.0336 | 0.9483 | |
| TCGA | PITX2 | 5308 | RNAseq | 1.0552 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by PITX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PITX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PITX2 | 5308 | 1 | 13 | 16 | |
| GSE20123 | PITX2 | 5308 | 1 | 13 | 16 | |
| GSE43470 | PITX2 | 5308 | 0 | 14 | 29 | |
| GSE46452 | PITX2 | 5308 | 1 | 36 | 22 | |
| GSE47630 | PITX2 | 5308 | 0 | 20 | 20 | |
| GSE54993 | PITX2 | 5308 | 9 | 0 | 61 | |
| GSE54994 | PITX2 | 5308 | 1 | 10 | 42 | |
| GSE60625 | PITX2 | 5308 | 0 | 3 | 8 | |
| GSE74703 | PITX2 | 5308 | 0 | 12 | 24 | |
| GSE74704 | PITX2 | 5308 | 0 | 7 | 13 | |
| TCGA | PITX2 | 5308 | 9 | 34 | 53 |
Total number of gains: 22; Total number of losses: 162; Total Number of normals: 304.
Somatic mutations of PITX2:
Generating mutation plots.
Highly correlated genes for PITX2:
Showing top 20/760 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PITX2 | BOD1 | 0.794723 | 3 | 0 | 3 |
| PITX2 | EIF5A2 | 0.791795 | 4 | 0 | 4 |
| PITX2 | NTPCR | 0.789832 | 3 | 0 | 3 |
| PITX2 | TDRKH | 0.781786 | 3 | 0 | 3 |
| PITX2 | ZFP1 | 0.779702 | 3 | 0 | 3 |
| PITX2 | COMMD7 | 0.775408 | 3 | 0 | 3 |
| PITX2 | C7orf50 | 0.773028 | 3 | 0 | 3 |
| PITX2 | PRELID2 | 0.771909 | 3 | 0 | 3 |
| PITX2 | GEMIN5 | 0.761941 | 3 | 0 | 3 |
| PITX2 | MXRA7 | 0.757651 | 3 | 0 | 3 |
| PITX2 | DHX37 | 0.755807 | 3 | 0 | 3 |
| PITX2 | CSNK2A2 | 0.745127 | 3 | 0 | 3 |
| PITX2 | CCM2 | 0.743845 | 3 | 0 | 3 |
| PITX2 | FHL3 | 0.738151 | 3 | 0 | 3 |
| PITX2 | CLIP2 | 0.737328 | 3 | 0 | 3 |
| PITX2 | TOP1MT | 0.735092 | 3 | 0 | 3 |
| PITX2 | SOCS4 | 0.730771 | 3 | 0 | 3 |
| PITX2 | GZF1 | 0.729502 | 3 | 0 | 3 |
| PITX2 | ARHGAP24 | 0.72603 | 4 | 0 | 4 |
| PITX2 | SP4 | 0.72458 | 3 | 0 | 3 |
For details and further investigation, click here
