| Full name: Sp4 transcription factor | Alias Symbol: SPR-1|HF1B|MGC130008|MGC130009 | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 6671 | HGNC ID: HGNC:11209 | Ensembl Gene: ENSG00000105866 | OMIM ID: 600540 |
| Drug and gene relationship at DGIdb | |||
Expression of SP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SP4 | 6671 | 236265_at | 0.2128 | 0.6816 | |
| GSE20347 | SP4 | 6671 | 206663_at | 0.1127 | 0.2445 | |
| GSE23400 | SP4 | 6671 | 206663_at | -0.0384 | 0.4809 | |
| GSE26886 | SP4 | 6671 | 236265_at | 1.6592 | 0.0000 | |
| GSE29001 | SP4 | 6671 | 206663_at | 0.1356 | 0.5839 | |
| GSE38129 | SP4 | 6671 | 206663_at | -0.0243 | 0.7562 | |
| GSE45670 | SP4 | 6671 | 236265_at | -0.2692 | 0.2240 | |
| GSE53622 | SP4 | 6671 | 42627 | 0.2837 | 0.0170 | |
| GSE53624 | SP4 | 6671 | 42627 | 0.5355 | 0.0000 | |
| GSE63941 | SP4 | 6671 | 236265_at | 1.4934 | 0.0162 | |
| GSE77861 | SP4 | 6671 | 236265_at | 0.5539 | 0.0248 | |
| GSE97050 | SP4 | 6671 | A_33_P3341716 | 0.0208 | 0.9633 | |
| SRP007169 | SP4 | 6671 | RNAseq | 1.5402 | 0.0183 | |
| SRP008496 | SP4 | 6671 | RNAseq | 1.7217 | 0.0001 | |
| SRP064894 | SP4 | 6671 | RNAseq | 0.4511 | 0.0343 | |
| SRP133303 | SP4 | 6671 | RNAseq | 0.1927 | 0.4384 | |
| SRP159526 | SP4 | 6671 | RNAseq | 0.1630 | 0.5051 | |
| SRP193095 | SP4 | 6671 | RNAseq | 0.4438 | 0.0058 | |
| SRP219564 | SP4 | 6671 | RNAseq | 0.3139 | 0.3525 | |
| TCGA | SP4 | 6671 | RNAseq | 0.0016 | 0.9862 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SP4 | 6671 | 16 | 2 | 12 | |
| GSE20123 | SP4 | 6671 | 16 | 2 | 12 | |
| GSE43470 | SP4 | 6671 | 4 | 0 | 39 | |
| GSE46452 | SP4 | 6671 | 10 | 2 | 47 | |
| GSE47630 | SP4 | 6671 | 9 | 1 | 30 | |
| GSE54993 | SP4 | 6671 | 0 | 6 | 64 | |
| GSE54994 | SP4 | 6671 | 20 | 2 | 31 | |
| GSE60625 | SP4 | 6671 | 0 | 0 | 11 | |
| GSE74703 | SP4 | 6671 | 4 | 0 | 32 | |
| GSE74704 | SP4 | 6671 | 10 | 2 | 8 | |
| TCGA | SP4 | 6671 | 56 | 5 | 35 |
Total number of gains: 145; Total number of losses: 22; Total Number of normals: 321.
Somatic mutations of SP4:
Generating mutation plots.
Highly correlated genes for SP4:
Showing top 20/1025 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SP4 | IDS | 0.808914 | 3 | 0 | 3 |
| SP4 | WIZ | 0.799377 | 3 | 0 | 3 |
| SP4 | ALKBH6 | 0.797116 | 3 | 0 | 3 |
| SP4 | GPS2 | 0.793102 | 3 | 0 | 3 |
| SP4 | NTPCR | 0.777251 | 3 | 0 | 3 |
| SP4 | CYB5D1 | 0.771858 | 3 | 0 | 3 |
| SP4 | PFN2 | 0.769744 | 3 | 0 | 3 |
| SP4 | LOXL1-AS1 | 0.769552 | 3 | 0 | 3 |
| SP4 | HAUS7 | 0.765078 | 3 | 0 | 3 |
| SP4 | TMEM138 | 0.756138 | 3 | 0 | 3 |
| SP4 | SLC7A6OS | 0.755783 | 3 | 0 | 3 |
| SP4 | PLOD3 | 0.754053 | 4 | 0 | 4 |
| SP4 | CDS2 | 0.754001 | 4 | 0 | 4 |
| SP4 | RILPL1 | 0.75229 | 3 | 0 | 3 |
| SP4 | MACF1 | 0.750653 | 4 | 0 | 4 |
| SP4 | UBB | 0.748012 | 4 | 0 | 4 |
| SP4 | PET117 | 0.747232 | 4 | 0 | 4 |
| SP4 | SLC38A10 | 0.743663 | 4 | 0 | 3 |
| SP4 | STMN3 | 0.742352 | 3 | 0 | 3 |
| SP4 | PRCC | 0.741491 | 3 | 0 | 3 |
For details and further investigation, click here
