| Full name: phospholipase A2 receptor 1 | Alias Symbol: PLA2G1R|PLA2IR|PLA2-R|CLEC13C | ||
| Type: protein-coding gene | Cytoband: 2q23-q24 | ||
| Entrez ID: 22925 | HGNC ID: HGNC:9042 | Ensembl Gene: ENSG00000153246 | OMIM ID: 604939 |
| Drug and gene relationship at DGIdb | |||
PLA2R1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of PLA2R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLA2R1 | 22925 | 235746_s_at | 0.2964 | 0.8368 | |
| GSE20347 | PLA2R1 | 22925 | 207415_at | 0.1124 | 0.4348 | |
| GSE23400 | PLA2R1 | 22925 | 207415_at | 0.1697 | 0.0001 | |
| GSE26886 | PLA2R1 | 22925 | 235746_s_at | 1.4441 | 0.0009 | |
| GSE29001 | PLA2R1 | 22925 | 207415_at | -0.1003 | 0.6461 | |
| GSE38129 | PLA2R1 | 22925 | 207415_at | 0.2376 | 0.0840 | |
| GSE45670 | PLA2R1 | 22925 | 235746_s_at | 0.0066 | 0.9893 | |
| GSE53622 | PLA2R1 | 22925 | 41925 | 0.2286 | 0.1034 | |
| GSE53624 | PLA2R1 | 22925 | 41925 | -0.0394 | 0.7489 | |
| GSE63941 | PLA2R1 | 22925 | 240039_at | -0.1865 | 0.4763 | |
| GSE77861 | PLA2R1 | 22925 | 235746_s_at | 0.7696 | 0.0939 | |
| GSE97050 | PLA2R1 | 22925 | A_23_P142830 | -0.1225 | 0.6785 | |
| SRP007169 | PLA2R1 | 22925 | RNAseq | 1.0617 | 0.0350 | |
| SRP008496 | PLA2R1 | 22925 | RNAseq | 1.1640 | 0.0054 | |
| SRP064894 | PLA2R1 | 22925 | RNAseq | 0.2077 | 0.5022 | |
| SRP133303 | PLA2R1 | 22925 | RNAseq | -0.3950 | 0.1987 | |
| SRP159526 | PLA2R1 | 22925 | RNAseq | 0.3459 | 0.4613 | |
| SRP193095 | PLA2R1 | 22925 | RNAseq | -0.0596 | 0.7855 | |
| SRP219564 | PLA2R1 | 22925 | RNAseq | -0.9227 | 0.1476 | |
| TCGA | PLA2R1 | 22925 | RNAseq | 0.2774 | 0.0376 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PLA2R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLA2R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLA2R1 | 22925 | 5 | 1 | 24 | |
| GSE20123 | PLA2R1 | 22925 | 5 | 1 | 24 | |
| GSE43470 | PLA2R1 | 22925 | 4 | 1 | 38 | |
| GSE46452 | PLA2R1 | 22925 | 1 | 4 | 54 | |
| GSE47630 | PLA2R1 | 22925 | 5 | 3 | 32 | |
| GSE54993 | PLA2R1 | 22925 | 0 | 4 | 66 | |
| GSE54994 | PLA2R1 | 22925 | 11 | 2 | 40 | |
| GSE60625 | PLA2R1 | 22925 | 0 | 3 | 8 | |
| GSE74703 | PLA2R1 | 22925 | 3 | 1 | 32 | |
| GSE74704 | PLA2R1 | 22925 | 3 | 0 | 17 | |
| TCGA | PLA2R1 | 22925 | 23 | 10 | 63 |
Total number of gains: 60; Total number of losses: 30; Total Number of normals: 398.
Somatic mutations of PLA2R1:
Generating mutation plots.
Highly correlated genes for PLA2R1:
Showing top 20/63 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLA2R1 | OGDH | 0.706716 | 3 | 0 | 3 |
| PLA2R1 | BFSP1 | 0.693304 | 3 | 0 | 3 |
| PLA2R1 | NIPA1 | 0.651803 | 3 | 0 | 3 |
| PLA2R1 | DLX6-AS1 | 0.64053 | 3 | 0 | 3 |
| PLA2R1 | NDUFAF7 | 0.628939 | 4 | 0 | 3 |
| PLA2R1 | C12orf75 | 0.624609 | 4 | 0 | 3 |
| PLA2R1 | DMRT2 | 0.623928 | 4 | 0 | 3 |
| PLA2R1 | PIGX | 0.619774 | 4 | 0 | 3 |
| PLA2R1 | KRTAP19-1 | 0.618922 | 4 | 0 | 4 |
| PLA2R1 | EPB41L4B | 0.607028 | 4 | 0 | 4 |
| PLA2R1 | ACKR3 | 0.606996 | 4 | 0 | 3 |
| PLA2R1 | PGP | 0.602487 | 4 | 0 | 3 |
| PLA2R1 | SRXN1 | 0.599648 | 4 | 0 | 3 |
| PLA2R1 | CALB1 | 0.598823 | 5 | 0 | 4 |
| PLA2R1 | BMP8B | 0.591465 | 3 | 0 | 3 |
| PLA2R1 | C7orf31 | 0.590018 | 3 | 0 | 3 |
| PLA2R1 | ABCA13 | 0.586642 | 4 | 0 | 3 |
| PLA2R1 | GLI2 | 0.5845 | 6 | 0 | 6 |
| PLA2R1 | MAPK10 | 0.582587 | 4 | 0 | 3 |
| PLA2R1 | GLTPD2 | 0.574262 | 3 | 0 | 3 |
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