| Full name: atypical chemokine receptor 3 | Alias Symbol: RDC1|GPR159 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 57007 | HGNC ID: HGNC:23692 | Ensembl Gene: ENSG00000144476 | OMIM ID: 610376 |
| Drug and gene relationship at DGIdb | |||
Expression of ACKR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACKR3 | 57007 | 212977_at | 0.4775 | 0.8466 | |
| GSE20347 | ACKR3 | 57007 | 212977_at | 2.5327 | 0.0000 | |
| GSE23400 | ACKR3 | 57007 | 212977_at | 1.1628 | 0.0000 | |
| GSE26886 | ACKR3 | 57007 | 212977_at | 1.7841 | 0.0072 | |
| GSE29001 | ACKR3 | 57007 | 212977_at | 1.6084 | 0.0028 | |
| GSE38129 | ACKR3 | 57007 | 212977_at | 1.7860 | 0.0000 | |
| GSE45670 | ACKR3 | 57007 | 212977_at | 0.8869 | 0.1394 | |
| GSE53622 | ACKR3 | 57007 | 105071 | 1.3026 | 0.0000 | |
| GSE53624 | ACKR3 | 57007 | 105071 | 1.4751 | 0.0000 | |
| GSE63941 | ACKR3 | 57007 | 212977_at | -5.0262 | 0.0371 | |
| GSE77861 | ACKR3 | 57007 | 212977_at | 2.6589 | 0.0103 | |
| SRP007169 | ACKR3 | 57007 | RNAseq | 3.5505 | 0.0000 | |
| SRP008496 | ACKR3 | 57007 | RNAseq | 3.0800 | 0.0001 | |
| SRP064894 | ACKR3 | 57007 | RNAseq | 1.3155 | 0.0001 | |
| SRP133303 | ACKR3 | 57007 | RNAseq | 1.7681 | 0.0000 | |
| SRP159526 | ACKR3 | 57007 | RNAseq | 2.3793 | 0.0002 | |
| SRP193095 | ACKR3 | 57007 | RNAseq | 3.2403 | 0.0000 | |
| SRP219564 | ACKR3 | 57007 | RNAseq | 1.3585 | 0.1084 |
Upregulated datasets: 14; Downregulated datasets: 1.
Survival by ACKR3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ACKR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACKR3 | 57007 | 1 | 11 | 18 | |
| GSE20123 | ACKR3 | 57007 | 1 | 11 | 18 | |
| GSE43470 | ACKR3 | 57007 | 1 | 9 | 33 | |
| GSE46452 | ACKR3 | 57007 | 0 | 5 | 54 | |
| GSE47630 | ACKR3 | 57007 | 4 | 5 | 31 | |
| GSE54993 | ACKR3 | 57007 | 3 | 2 | 65 | |
| GSE54994 | ACKR3 | 57007 | 8 | 10 | 35 | |
| GSE60625 | ACKR3 | 57007 | 0 | 3 | 8 | |
| GSE74703 | ACKR3 | 57007 | 1 | 7 | 28 | |
| GSE74704 | ACKR3 | 57007 | 1 | 5 | 14 | |
| TCGA | ACKR3 | 57007 | 11 | 27 | 58 |
Total number of gains: 31; Total number of losses: 95; Total Number of normals: 362.
Somatic mutations of ACKR3:
Generating mutation plots.
Highly correlated genes for ACKR3:
Showing top 20/620 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACKR3 | TGFBI | 0.676443 | 11 | 0 | 11 |
| ACKR3 | MFAP2 | 0.657441 | 9 | 0 | 8 |
| ACKR3 | TRAM2 | 0.655629 | 9 | 0 | 9 |
| ACKR3 | ODC1 | 0.65462 | 10 | 0 | 10 |
| ACKR3 | ACVR1 | 0.652175 | 11 | 0 | 10 |
| ACKR3 | SPP1 | 0.649852 | 9 | 0 | 8 |
| ACKR3 | MFHAS1 | 0.644621 | 9 | 0 | 8 |
| ACKR3 | PFN2 | 0.642857 | 10 | 0 | 9 |
| ACKR3 | ZIC5 | 0.642014 | 3 | 0 | 3 |
| ACKR3 | ABCA13 | 0.641381 | 5 | 0 | 3 |
| ACKR3 | LRP12 | 0.641215 | 10 | 0 | 10 |
| ACKR3 | MMP11 | 0.640525 | 7 | 0 | 6 |
| ACKR3 | IGFBP3 | 0.639557 | 10 | 0 | 9 |
| ACKR3 | TENM2 | 0.637523 | 6 | 0 | 6 |
| ACKR3 | SIX4 | 0.633165 | 5 | 0 | 5 |
| ACKR3 | SNAI2 | 0.631638 | 8 | 0 | 7 |
| ACKR3 | PTK2 | 0.627192 | 9 | 0 | 9 |
| ACKR3 | AMDHD1 | 0.627157 | 3 | 0 | 3 |
| ACKR3 | TXNRD1 | 0.622893 | 10 | 0 | 9 |
| ACKR3 | RAI14 | 0.622347 | 10 | 0 | 9 |
For details and further investigation, click here
