| Full name: oxoglutarate dehydrogenase | Alias Symbol: E1k | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 4967 | HGNC ID: HGNC:8124 | Ensembl Gene: ENSG00000105953 | OMIM ID: 613022 |
Screen Evidence:
| |||
Expression of OGDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OGDH | 4967 | 201282_at | 0.2049 | 0.6499 | |
| GSE20347 | OGDH | 4967 | 201282_at | 0.1869 | 0.1221 | |
| GSE23400 | OGDH | 4967 | 201282_at | -0.0044 | 0.9501 | |
| GSE26886 | OGDH | 4967 | 1554151_at | 0.4815 | 0.0043 | |
| GSE29001 | OGDH | 4967 | 201282_at | 0.0319 | 0.8932 | |
| GSE38129 | OGDH | 4967 | 201282_at | 0.0199 | 0.8823 | |
| GSE45670 | OGDH | 4967 | 201282_at | 0.2060 | 0.0290 | |
| GSE53622 | OGDH | 4967 | 23626 | -0.2828 | 0.0006 | |
| GSE53624 | OGDH | 4967 | 23626 | -0.0733 | 0.3152 | |
| GSE63941 | OGDH | 4967 | 201282_at | 1.5054 | 0.0023 | |
| GSE77861 | OGDH | 4967 | 201282_at | 0.4047 | 0.0332 | |
| GSE97050 | OGDH | 4967 | A_24_P290770 | -0.3184 | 0.4530 | |
| SRP007169 | OGDH | 4967 | RNAseq | -0.6732 | 0.0746 | |
| SRP008496 | OGDH | 4967 | RNAseq | -0.4770 | 0.0416 | |
| SRP064894 | OGDH | 4967 | RNAseq | -0.1729 | 0.1747 | |
| SRP133303 | OGDH | 4967 | RNAseq | 0.1610 | 0.2812 | |
| SRP159526 | OGDH | 4967 | RNAseq | -0.0028 | 0.9898 | |
| SRP193095 | OGDH | 4967 | RNAseq | -0.1162 | 0.3536 | |
| SRP219564 | OGDH | 4967 | RNAseq | -0.4663 | 0.2475 | |
| TCGA | OGDH | 4967 | RNAseq | -0.1452 | 0.0026 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by OGDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OGDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OGDH | 4967 | 13 | 0 | 17 | |
| GSE20123 | OGDH | 4967 | 13 | 0 | 17 | |
| GSE43470 | OGDH | 4967 | 4 | 0 | 39 | |
| GSE46452 | OGDH | 4967 | 11 | 1 | 47 | |
| GSE47630 | OGDH | 4967 | 8 | 1 | 31 | |
| GSE54993 | OGDH | 4967 | 0 | 8 | 62 | |
| GSE54994 | OGDH | 4967 | 16 | 3 | 34 | |
| GSE60625 | OGDH | 4967 | 0 | 0 | 11 | |
| GSE74703 | OGDH | 4967 | 4 | 0 | 32 | |
| GSE74704 | OGDH | 4967 | 7 | 0 | 13 | |
| TCGA | OGDH | 4967 | 50 | 7 | 39 |
Total number of gains: 126; Total number of losses: 20; Total Number of normals: 342.
Somatic mutations of OGDH:
Generating mutation plots.
Highly correlated genes for OGDH:
Showing top 20/578 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OGDH | DDB1 | 0.784339 | 3 | 0 | 3 |
| OGDH | SFT2D3 | 0.760885 | 3 | 0 | 3 |
| OGDH | TMED4 | 0.755774 | 3 | 0 | 3 |
| OGDH | ELMOD3 | 0.750742 | 3 | 0 | 3 |
| OGDH | C1orf43 | 0.738352 | 3 | 0 | 3 |
| OGDH | MLLT11 | 0.731688 | 3 | 0 | 3 |
| OGDH | ABHD2 | 0.728333 | 3 | 0 | 3 |
| OGDH | CDH24 | 0.720925 | 3 | 0 | 3 |
| OGDH | DDX18 | 0.71413 | 4 | 0 | 4 |
| OGDH | DMRT2 | 0.710997 | 3 | 0 | 3 |
| OGDH | PLA2R1 | 0.706716 | 3 | 0 | 3 |
| OGDH | QSOX2 | 0.704295 | 3 | 0 | 3 |
| OGDH | CXXC1 | 0.701648 | 4 | 0 | 3 |
| OGDH | EXOC3L1 | 0.697466 | 3 | 0 | 3 |
| OGDH | NGF | 0.697025 | 4 | 0 | 3 |
| OGDH | METTL23 | 0.695747 | 3 | 0 | 3 |
| OGDH | TARBP1 | 0.695727 | 3 | 0 | 3 |
| OGDH | WIPF3 | 0.693149 | 3 | 0 | 3 |
| OGDH | SAMD1 | 0.692024 | 4 | 0 | 3 |
| OGDH | FOXN2 | 0.691651 | 4 | 0 | 4 |
For details and further investigation, click here
