PLCB1

 

Full name: phospholipase C beta 1 Alias Symbol: KIAA0581|PLC-I|PLC154
Type: protein-coding gene Cytoband: 20p12.3
Entrez ID: 23236 HGNC ID: HGNC:15917 Ensembl Gene: ENSG00000182621 OMIM ID: 607120
Drug and gene relationship at DGIdb

 

PLCB1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of PLCB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCB1 23236 213222_at -0.9218 0.5644
GSE20347 PLCB1 23236 213222_at 0.5404 0.2437
GSE23400 PLCB1 23236 213222_at 0.1709 0.3814
GSE26886 PLCB1 23236 213222_at 1.7493 0.0030
GSE29001 PLCB1 23236 213222_at 0.5742 0.3275
GSE38129 PLCB1 23236 213222_at 0.2040 0.6919
GSE45670 PLCB1 23236 213222_at -0.7040 0.1256
GSE53622 PLCB1 23236 91733 0.0107 0.9444
GSE53624 PLCB1 23236 91733 0.2283 0.0016
GSE63941 PLCB1 23236 213222_at -2.4777 0.0435
GSE77861 PLCB1 23236 215687_x_at -0.1398 0.3503
GSE97050 PLCB1 23236 A_24_P941643 -0.5136 0.5057
SRP007169 PLCB1 23236 RNAseq 1.7338 0.0054
SRP008496 PLCB1 23236 RNAseq 1.8019 0.0000
SRP064894 PLCB1 23236 RNAseq 0.4630 0.0966
SRP133303 PLCB1 23236 RNAseq 0.1128 0.6902
SRP159526 PLCB1 23236 RNAseq 1.1713 0.0013
SRP193095 PLCB1 23236 RNAseq 1.3381 0.0000
SRP219564 PLCB1 23236 RNAseq 0.1992 0.7725
TCGA PLCB1 23236 RNAseq -0.2642 0.0290

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by PLCB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCB1 23236 10 2 18
GSE20123 PLCB1 23236 10 2 18
GSE43470 PLCB1 23236 11 1 31
GSE46452 PLCB1 23236 26 1 32
GSE47630 PLCB1 23236 18 4 18
GSE54993 PLCB1 23236 1 14 55
GSE54994 PLCB1 23236 25 2 26
GSE60625 PLCB1 23236 0 0 11
GSE74703 PLCB1 23236 8 1 27
GSE74704 PLCB1 23236 5 1 14
TCGA PLCB1 23236 41 12 43

Total number of gains: 155; Total number of losses: 40; Total Number of normals: 293.  

 

Somatic mutations of PLCB1:

 

Generating mutation plots.

 

Highly correlated genes for PLCB1:

 

Showing top 20/586 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCB1YPEL20.761341303
PLCB1RANBP3L0.759475303
PLCB1LINC011110.699007303
PLCB1MYADM0.697051303
PLCB1FRMD30.69484303
PLCB1MPDZ0.6946491009
PLCB1SCN4B0.69421303
PLCB1ENPP40.686244706
PLCB1COLEC100.666241303
PLCB1MICU30.665908403
PLCB1NEGR10.658529403
PLCB1FXYD10.655001403
PLCB1MYEF20.652086403
PLCB1A2M-AS10.651319403
PLCB1FGL20.648808705
PLCB1GADL10.646812303
PLCB1CASQ20.645736605
PLCB1HSPA12A0.643173404
PLCB1BEND50.640754706
PLCB1CDH190.638695605

For details and further investigation, click here