| Full name: ectonucleotide pyrophosphatase/phosphodiesterase 4 | Alias Symbol: NPP4|KIAA0879|AP3Aase | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 22875 | HGNC ID: HGNC:3359 | Ensembl Gene: ENSG00000001561 | OMIM ID: 617000 |
Expression of ENPP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENPP4 | 22875 | 204160_s_at | -0.7413 | 0.6307 | |
| GSE20347 | ENPP4 | 22875 | 204160_s_at | 0.3039 | 0.2781 | |
| GSE23400 | ENPP4 | 22875 | 204160_s_at | -0.0666 | 0.5030 | |
| GSE26886 | ENPP4 | 22875 | 204160_s_at | 0.2457 | 0.7414 | |
| GSE29001 | ENPP4 | 22875 | 204160_s_at | 0.1620 | 0.7205 | |
| GSE38129 | ENPP4 | 22875 | 204160_s_at | -0.1288 | 0.7570 | |
| GSE45670 | ENPP4 | 22875 | 204160_s_at | -1.4751 | 0.0007 | |
| GSE53622 | ENPP4 | 22875 | 23514 | -0.9141 | 0.0000 | |
| GSE53624 | ENPP4 | 22875 | 23514 | -0.9059 | 0.0000 | |
| GSE63941 | ENPP4 | 22875 | 204160_s_at | -1.8033 | 0.2587 | |
| GSE77861 | ENPP4 | 22875 | 204160_s_at | 0.1538 | 0.5823 | |
| GSE97050 | ENPP4 | 22875 | A_23_P70318 | -0.4914 | 0.2867 | |
| SRP007169 | ENPP4 | 22875 | RNAseq | 1.4145 | 0.0911 | |
| SRP008496 | ENPP4 | 22875 | RNAseq | 0.5155 | 0.3022 | |
| SRP064894 | ENPP4 | 22875 | RNAseq | -0.1617 | 0.6654 | |
| SRP133303 | ENPP4 | 22875 | RNAseq | -0.0170 | 0.9618 | |
| SRP159526 | ENPP4 | 22875 | RNAseq | 0.2581 | 0.6255 | |
| SRP193095 | ENPP4 | 22875 | RNAseq | -0.2090 | 0.6239 | |
| SRP219564 | ENPP4 | 22875 | RNAseq | -0.0501 | 0.9486 | |
| TCGA | ENPP4 | 22875 | RNAseq | -1.1319 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ENPP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENPP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENPP4 | 22875 | 6 | 2 | 22 | |
| GSE20123 | ENPP4 | 22875 | 6 | 2 | 22 | |
| GSE43470 | ENPP4 | 22875 | 6 | 0 | 37 | |
| GSE46452 | ENPP4 | 22875 | 2 | 10 | 47 | |
| GSE47630 | ENPP4 | 22875 | 7 | 5 | 28 | |
| GSE54993 | ENPP4 | 22875 | 3 | 1 | 66 | |
| GSE54994 | ENPP4 | 22875 | 8 | 3 | 42 | |
| GSE60625 | ENPP4 | 22875 | 0 | 3 | 8 | |
| GSE74703 | ENPP4 | 22875 | 6 | 0 | 30 | |
| GSE74704 | ENPP4 | 22875 | 2 | 1 | 17 | |
| TCGA | ENPP4 | 22875 | 18 | 14 | 64 |
Total number of gains: 64; Total number of losses: 41; Total Number of normals: 383.
Somatic mutations of ENPP4:
Generating mutation plots.
Highly correlated genes for ENPP4:
Showing top 20/692 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENPP4 | PGR | 0.764523 | 5 | 0 | 5 |
| ENPP4 | NEGR1 | 0.759312 | 5 | 0 | 5 |
| ENPP4 | ANO5 | 0.732744 | 5 | 0 | 5 |
| ENPP4 | SORCS1 | 0.730258 | 4 | 0 | 4 |
| ENPP4 | PARD3B | 0.725915 | 4 | 0 | 4 |
| ENPP4 | RNF150 | 0.714848 | 5 | 0 | 5 |
| ENPP4 | DPT | 0.710233 | 7 | 0 | 7 |
| ENPP4 | RERG | 0.706371 | 5 | 0 | 5 |
| ENPP4 | DACT3 | 0.705492 | 5 | 0 | 5 |
| ENPP4 | CBX7 | 0.703813 | 9 | 0 | 8 |
| ENPP4 | CYP2U1 | 0.699576 | 6 | 0 | 5 |
| ENPP4 | ADAMTSL1 | 0.696357 | 5 | 0 | 5 |
| ENPP4 | C1QTNF7 | 0.690696 | 5 | 0 | 5 |
| ENPP4 | MAGI2-AS3 | 0.689197 | 4 | 0 | 4 |
| ENPP4 | PLCB1 | 0.686244 | 7 | 0 | 6 |
| ENPP4 | FGF7 | 0.684542 | 7 | 0 | 7 |
| ENPP4 | PLP1 | 0.683821 | 6 | 0 | 6 |
| ENPP4 | CNN1 | 0.683191 | 5 | 0 | 4 |
| ENPP4 | CYP21A2 | 0.682375 | 3 | 0 | 3 |
| ENPP4 | PPP1R14A | 0.679048 | 5 | 0 | 4 |
For details and further investigation, click here
