| Full name: sodium voltage-gated channel beta subunit 4 | Alias Symbol: LQT10 | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 6330 | HGNC ID: HGNC:10592 | Ensembl Gene: ENSG00000177098 | OMIM ID: 608256 |
| Drug and gene relationship at DGIdb | |||
SCN4B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of SCN4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN4B | 6330 | 236359_at | -1.6206 | 0.0399 | |
| GSE26886 | SCN4B | 6330 | 236359_at | -0.0394 | 0.9019 | |
| GSE45670 | SCN4B | 6330 | 236359_at | -1.7954 | 0.0002 | |
| GSE53622 | SCN4B | 6330 | 72784 | -0.9219 | 0.0000 | |
| GSE53624 | SCN4B | 6330 | 72784 | -0.9006 | 0.0000 | |
| GSE63941 | SCN4B | 6330 | 236359_at | -2.4580 | 0.0000 | |
| GSE77861 | SCN4B | 6330 | 236359_at | -0.2059 | 0.0820 | |
| GSE97050 | SCN4B | 6330 | A_23_P303833 | -0.5282 | 0.2504 | |
| SRP007169 | SCN4B | 6330 | RNAseq | -1.0648 | 0.0666 | |
| SRP064894 | SCN4B | 6330 | RNAseq | -0.5983 | 0.1183 | |
| SRP133303 | SCN4B | 6330 | RNAseq | -1.5803 | 0.0000 | |
| SRP159526 | SCN4B | 6330 | RNAseq | -1.6555 | 0.0000 | |
| SRP193095 | SCN4B | 6330 | RNAseq | -0.0383 | 0.9020 | |
| SRP219564 | SCN4B | 6330 | RNAseq | -0.9307 | 0.2032 | |
| TCGA | SCN4B | 6330 | RNAseq | -0.4811 | 0.0150 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by SCN4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN4B | 6330 | 2 | 11 | 17 | |
| GSE20123 | SCN4B | 6330 | 2 | 11 | 17 | |
| GSE43470 | SCN4B | 6330 | 2 | 9 | 32 | |
| GSE46452 | SCN4B | 6330 | 3 | 26 | 30 | |
| GSE47630 | SCN4B | 6330 | 2 | 19 | 19 | |
| GSE54993 | SCN4B | 6330 | 10 | 0 | 60 | |
| GSE54994 | SCN4B | 6330 | 6 | 19 | 28 | |
| GSE60625 | SCN4B | 6330 | 0 | 3 | 8 | |
| GSE74703 | SCN4B | 6330 | 1 | 6 | 29 | |
| GSE74704 | SCN4B | 6330 | 1 | 7 | 12 | |
| TCGA | SCN4B | 6330 | 5 | 50 | 41 |
Total number of gains: 34; Total number of losses: 161; Total Number of normals: 293.
Somatic mutations of SCN4B:
Generating mutation plots.
Highly correlated genes for SCN4B:
Showing top 20/803 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN4B | GRIK2 | 0.738584 | 3 | 0 | 3 |
| SCN4B | DAAM2 | 0.734104 | 4 | 0 | 3 |
| SCN4B | FXYD1 | 0.731499 | 4 | 0 | 3 |
| SCN4B | MYOCD | 0.727374 | 6 | 0 | 6 |
| SCN4B | DMPK | 0.723716 | 3 | 0 | 3 |
| SCN4B | SYNC | 0.713019 | 4 | 0 | 4 |
| SCN4B | FIBIN | 0.710397 | 6 | 0 | 6 |
| SCN4B | TIMP3 | 0.70839 | 5 | 0 | 4 |
| SCN4B | TMOD1 | 0.705569 | 4 | 0 | 4 |
| SCN4B | EML1 | 0.704231 | 4 | 0 | 4 |
| SCN4B | ACTC1 | 0.699504 | 3 | 0 | 3 |
| SCN4B | RAB11B-AS1 | 0.697106 | 3 | 0 | 3 |
| SCN4B | ZSCAN18 | 0.696087 | 5 | 0 | 5 |
| SCN4B | FAM13C | 0.69567 | 5 | 0 | 5 |
| SCN4B | PLCB1 | 0.69421 | 3 | 0 | 3 |
| SCN4B | ABCA6 | 0.692251 | 6 | 0 | 5 |
| SCN4B | XKR4 | 0.692212 | 5 | 0 | 5 |
| SCN4B | FGFR1 | 0.691186 | 4 | 0 | 3 |
| SCN4B | ID4 | 0.690701 | 4 | 0 | 4 |
| SCN4B | FHL5 | 0.690259 | 5 | 0 | 5 |
For details and further investigation, click here
