LCP2

 

Full name: lymphocyte cytosolic protein 2 Alias Symbol: SLP-76
Type: protein-coding gene Cytoband: 5q35.1
Entrez ID: 3937 HGNC ID: HGNC:6529 Ensembl Gene: ENSG00000043462 OMIM ID: 601603
Drug and gene relationship at DGIdb

 

LCP2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04380Osteoclast differentiation
hsa04611Platelet activation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway

 

Expression of LCP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LCP2 3937 205270_s_at 0.6478 0.5228
GSE20347 LCP2 3937 205270_s_at -0.0322 0.8850
GSE23400 LCP2 3937 205270_s_at 0.1229 0.0604
GSE26886 LCP2 3937 205270_s_at -0.2837 0.2584
GSE29001 LCP2 3937 205270_s_at 0.0559 0.8626
GSE38129 LCP2 3937 205270_s_at 0.0768 0.7352
GSE45670 LCP2 3937 205270_s_at 0.0325 0.9334
GSE53622 LCP2 3937 3943 0.8226 0.0000
GSE53624 LCP2 3937 3943 0.5595 0.0001
GSE63941 LCP2 3937 244598_at 0.2275 0.0987
GSE77861 LCP2 3937 205270_s_at -0.1078 0.5731
GSE97050 LCP2 3937 A_23_P30547 0.7166 0.2280
SRP007169 LCP2 3937 RNAseq 1.6933 0.0171
SRP008496 LCP2 3937 RNAseq 1.3949 0.0029
SRP064894 LCP2 3937 RNAseq 0.8946 0.0002
SRP133303 LCP2 3937 RNAseq 0.8867 0.0004
SRP159526 LCP2 3937 RNAseq -0.1050 0.8717
SRP193095 LCP2 3937 RNAseq 1.1578 0.0000
SRP219564 LCP2 3937 RNAseq 0.8334 0.0522
TCGA LCP2 3937 RNAseq 0.2270 0.0685

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by LCP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LCP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LCP2 3937 1 13 16
GSE20123 LCP2 3937 1 13 16
GSE43470 LCP2 3937 1 9 33
GSE46452 LCP2 3937 0 27 32
GSE47630 LCP2 3937 0 20 20
GSE54993 LCP2 3937 9 2 59
GSE54994 LCP2 3937 2 15 36
GSE60625 LCP2 3937 1 0 10
GSE74703 LCP2 3937 1 6 29
GSE74704 LCP2 3937 0 6 14
TCGA LCP2 3937 7 36 53

Total number of gains: 23; Total number of losses: 147; Total Number of normals: 318.  

 

Somatic mutations of LCP2:

 

Generating mutation plots.

 

Highly correlated genes for LCP2:

 

Showing top 20/525 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LCP2PIK3R50.836706505
LCP2C19orf380.798058303
LCP2SUCNR10.796226404
LCP2SNX200.788256606
LCP2CERKL0.781256303
LCP2PIK3AP10.778283504
LCP2IL12RB10.773363505
LCP2PLCB20.770988404
LCP2TYROBP0.763073909
LCP2ARHGAP90.761776606
LCP2CD530.753112908
LCP2PARVG0.746571606
LCP2TNFSF80.746396404
LCP2IGSF60.740831908
LCP2PREX10.738379403
LCP2LRRC8C0.737301303
LCP2SLAMF80.735344909
LCP2ITGB20.735281009
LCP2LAIR10.733312807
LCP2GPR1320.727559404

For details and further investigation, click here