| Full name: pleckstrin homology and RhoGEF domain containing G5 | Alias Symbol: KIAA0720|Syx|GEF720|Tech | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 57449 | HGNC ID: HGNC:29105 | Ensembl Gene: ENSG00000171680 | OMIM ID: 611101 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG5 | 57449 | 227142_at | 0.1612 | 0.7523 | |
| GSE26886 | PLEKHG5 | 57449 | 227142_at | 0.2022 | 0.1246 | |
| GSE45670 | PLEKHG5 | 57449 | 227142_at | 0.0916 | 0.4025 | |
| GSE53622 | PLEKHG5 | 57449 | 22741 | 0.1689 | 0.0123 | |
| GSE53624 | PLEKHG5 | 57449 | 22741 | -0.0200 | 0.7720 | |
| GSE63941 | PLEKHG5 | 57449 | 227142_at | 0.4772 | 0.0085 | |
| GSE77861 | PLEKHG5 | 57449 | 227142_at | -0.0191 | 0.9259 | |
| GSE97050 | PLEKHG5 | 57449 | A_33_P3272539 | 0.0120 | 0.9695 | |
| SRP007169 | PLEKHG5 | 57449 | RNAseq | -1.4080 | 0.0013 | |
| SRP008496 | PLEKHG5 | 57449 | RNAseq | -0.8087 | 0.0245 | |
| SRP064894 | PLEKHG5 | 57449 | RNAseq | 0.1459 | 0.4788 | |
| SRP133303 | PLEKHG5 | 57449 | RNAseq | -0.2985 | 0.1618 | |
| SRP159526 | PLEKHG5 | 57449 | RNAseq | -0.4059 | 0.0513 | |
| SRP193095 | PLEKHG5 | 57449 | RNAseq | 0.3624 | 0.1045 | |
| SRP219564 | PLEKHG5 | 57449 | RNAseq | -0.5817 | 0.0633 | |
| TCGA | PLEKHG5 | 57449 | RNAseq | 0.4375 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PLEKHG5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG5 | 57449 | 3 | 6 | 21 | |
| GSE20123 | PLEKHG5 | 57449 | 3 | 5 | 22 | |
| GSE43470 | PLEKHG5 | 57449 | 6 | 5 | 32 | |
| GSE46452 | PLEKHG5 | 57449 | 7 | 1 | 51 | |
| GSE47630 | PLEKHG5 | 57449 | 8 | 4 | 28 | |
| GSE54993 | PLEKHG5 | 57449 | 3 | 2 | 65 | |
| GSE54994 | PLEKHG5 | 57449 | 14 | 3 | 36 | |
| GSE60625 | PLEKHG5 | 57449 | 0 | 0 | 11 | |
| GSE74703 | PLEKHG5 | 57449 | 5 | 3 | 28 | |
| GSE74704 | PLEKHG5 | 57449 | 3 | 0 | 17 | |
| TCGA | PLEKHG5 | 57449 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of PLEKHG5:
Generating mutation plots.
Highly correlated genes for PLEKHG5:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG5 | ARHGAP33 | 0.808091 | 3 | 0 | 3 |
| PLEKHG5 | OR2T12 | 0.756822 | 3 | 0 | 3 |
| PLEKHG5 | ELFN1 | 0.725064 | 4 | 0 | 4 |
| PLEKHG5 | PEX26 | 0.686764 | 4 | 0 | 4 |
| PLEKHG5 | SFTPA2 | 0.685097 | 3 | 0 | 3 |
| PLEKHG5 | CDC42EP5 | 0.678042 | 3 | 0 | 3 |
| PLEKHG5 | HES6 | 0.671526 | 5 | 0 | 4 |
| PLEKHG5 | CARD10 | 0.651228 | 5 | 0 | 4 |
| PLEKHG5 | CCNB3 | 0.6406 | 4 | 0 | 3 |
| PLEKHG5 | DOT1L | 0.630208 | 4 | 0 | 4 |
| PLEKHG5 | FBXL19 | 0.628878 | 4 | 0 | 4 |
| PLEKHG5 | HMG20B | 0.623595 | 3 | 0 | 3 |
| PLEKHG5 | ADAMTSL2 | 0.623105 | 4 | 0 | 3 |
| PLEKHG5 | ADAMTSL5 | 0.618639 | 6 | 0 | 5 |
| PLEKHG5 | SBNO2 | 0.617683 | 4 | 0 | 3 |
| PLEKHG5 | LBX1 | 0.61655 | 3 | 0 | 3 |
| PLEKHG5 | DGKA | 0.607641 | 3 | 0 | 3 |
| PLEKHG5 | IGF2 | 0.604778 | 3 | 0 | 3 |
| PLEKHG5 | NOP14-AS1 | 0.604016 | 4 | 0 | 3 |
| PLEKHG5 | LSR | 0.60278 | 3 | 0 | 3 |
For details and further investigation, click here
