| Full name: phosphomevalonate kinase | Alias Symbol: PMK|PMKA|HUMPMKI | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 10654 | HGNC ID: HGNC:9141 | Ensembl Gene: ENSG00000163344 | OMIM ID: 607622 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PMVK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PMVK | 10654 | 203515_s_at | -0.2296 | 0.7196 | |
| GSE20347 | PMVK | 10654 | 203515_s_at | -0.7978 | 0.0000 | |
| GSE23400 | PMVK | 10654 | 203515_s_at | -0.5474 | 0.0000 | |
| GSE26886 | PMVK | 10654 | 203515_s_at | -1.1004 | 0.0018 | |
| GSE29001 | PMVK | 10654 | 203515_s_at | -0.5816 | 0.0986 | |
| GSE38129 | PMVK | 10654 | 203515_s_at | -0.4672 | 0.0024 | |
| GSE45670 | PMVK | 10654 | 203515_s_at | -0.3402 | 0.0067 | |
| GSE53622 | PMVK | 10654 | 178479 | -0.9491 | 0.0000 | |
| GSE53624 | PMVK | 10654 | 178479 | -0.9388 | 0.0000 | |
| GSE63941 | PMVK | 10654 | 203515_s_at | 0.4399 | 0.4203 | |
| GSE77861 | PMVK | 10654 | 203515_s_at | -0.4102 | 0.0264 | |
| GSE97050 | PMVK | 10654 | A_23_P114774 | -0.5261 | 0.1572 | |
| SRP007169 | PMVK | 10654 | RNAseq | -2.1009 | 0.0000 | |
| SRP008496 | PMVK | 10654 | RNAseq | -1.4348 | 0.0000 | |
| SRP064894 | PMVK | 10654 | RNAseq | -0.1984 | 0.5821 | |
| SRP133303 | PMVK | 10654 | RNAseq | -0.8032 | 0.0000 | |
| SRP159526 | PMVK | 10654 | RNAseq | -0.8510 | 0.0000 | |
| SRP193095 | PMVK | 10654 | RNAseq | -1.2263 | 0.0000 | |
| SRP219564 | PMVK | 10654 | RNAseq | -0.4153 | 0.2503 | |
| TCGA | PMVK | 10654 | RNAseq | -0.1217 | 0.0997 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PMVK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PMVK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PMVK | 10654 | 14 | 0 | 16 | |
| GSE20123 | PMVK | 10654 | 13 | 0 | 17 | |
| GSE43470 | PMVK | 10654 | 6 | 2 | 35 | |
| GSE46452 | PMVK | 10654 | 2 | 1 | 56 | |
| GSE47630 | PMVK | 10654 | 14 | 0 | 26 | |
| GSE54993 | PMVK | 10654 | 0 | 4 | 66 | |
| GSE54994 | PMVK | 10654 | 16 | 0 | 37 | |
| GSE60625 | PMVK | 10654 | 0 | 0 | 11 | |
| GSE74703 | PMVK | 10654 | 6 | 1 | 29 | |
| GSE74704 | PMVK | 10654 | 6 | 0 | 14 | |
| TCGA | PMVK | 10654 | 38 | 2 | 56 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of PMVK:
Generating mutation plots.
Highly correlated genes for PMVK:
Showing top 20/1227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PMVK | EIF4H | 0.768945 | 3 | 0 | 3 |
| PMVK | GBP6 | 0.752246 | 3 | 0 | 3 |
| PMVK | MPP7 | 0.733569 | 6 | 0 | 6 |
| PMVK | PRDX5 | 0.728817 | 5 | 0 | 5 |
| PMVK | FBXO10 | 0.728712 | 3 | 0 | 3 |
| PMVK | ACAA1 | 0.728068 | 8 | 0 | 8 |
| PMVK | CCNYL1 | 0.721608 | 4 | 0 | 4 |
| PMVK | BRK1 | 0.717101 | 6 | 0 | 6 |
| PMVK | TMEM120A | 0.716767 | 6 | 0 | 5 |
| PMVK | NAGK | 0.711343 | 10 | 0 | 10 |
| PMVK | ANKZF1 | 0.706979 | 3 | 0 | 3 |
| PMVK | DBNL | 0.706859 | 3 | 0 | 3 |
| PMVK | ST6GALNAC6 | 0.701402 | 4 | 0 | 4 |
| PMVK | KLHDC8B | 0.700584 | 6 | 0 | 6 |
| PMVK | SNX12 | 0.694216 | 4 | 0 | 3 |
| PMVK | ANKRD35 | 0.693295 | 6 | 0 | 6 |
| PMVK | PINK1 | 0.692161 | 8 | 0 | 8 |
| PMVK | PRMT2 | 0.691455 | 8 | 0 | 8 |
| PMVK | S100A16 | 0.691343 | 6 | 0 | 5 |
| PMVK | YPEL3 | 0.687452 | 5 | 0 | 4 |
For details and further investigation, click here
