| Full name: PTEN induced kinase 1 | Alias Symbol: BRPK | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 65018 | HGNC ID: HGNC:14581 | Ensembl Gene: ENSG00000158828 | OMIM ID: 608309 |
| Drug and gene relationship at DGIdb | |||
Expression of PINK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PINK1 | 65018 | 209018_s_at | -0.7706 | 0.0291 | |
| GSE20347 | PINK1 | 65018 | 209018_s_at | -1.3880 | 0.0000 | |
| GSE23400 | PINK1 | 65018 | 209018_s_at | -0.8075 | 0.0000 | |
| GSE26886 | PINK1 | 65018 | 209019_s_at | -0.8515 | 0.0050 | |
| GSE29001 | PINK1 | 65018 | 209019_s_at | -1.2117 | 0.0000 | |
| GSE38129 | PINK1 | 65018 | 209019_s_at | -1.1103 | 0.0000 | |
| GSE45670 | PINK1 | 65018 | 209019_s_at | -0.4918 | 0.0281 | |
| GSE63941 | PINK1 | 65018 | 209019_s_at | -1.6073 | 0.0020 | |
| GSE77861 | PINK1 | 65018 | 209019_s_at | -0.6226 | 0.0028 | |
| GSE97050 | PINK1 | 65018 | A_23_P23194 | -0.5024 | 0.1210 | |
| SRP007169 | PINK1 | 65018 | RNAseq | -2.4637 | 0.0000 | |
| SRP008496 | PINK1 | 65018 | RNAseq | -1.8498 | 0.0000 | |
| SRP064894 | PINK1 | 65018 | RNAseq | -0.7672 | 0.0029 | |
| SRP133303 | PINK1 | 65018 | RNAseq | -0.7520 | 0.0049 | |
| SRP159526 | PINK1 | 65018 | RNAseq | -1.1949 | 0.0000 | |
| SRP193095 | PINK1 | 65018 | RNAseq | -1.0897 | 0.0000 | |
| SRP219564 | PINK1 | 65018 | RNAseq | -1.3360 | 0.0016 | |
| TCGA | PINK1 | 65018 | RNAseq | -0.3512 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by PINK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PINK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PINK1 | 65018 | 0 | 5 | 25 | |
| GSE20123 | PINK1 | 65018 | 0 | 4 | 26 | |
| GSE43470 | PINK1 | 65018 | 0 | 8 | 35 | |
| GSE46452 | PINK1 | 65018 | 5 | 1 | 53 | |
| GSE47630 | PINK1 | 65018 | 8 | 3 | 29 | |
| GSE54993 | PINK1 | 65018 | 3 | 1 | 66 | |
| GSE54994 | PINK1 | 65018 | 11 | 4 | 38 | |
| GSE60625 | PINK1 | 65018 | 0 | 0 | 11 | |
| GSE74703 | PINK1 | 65018 | 0 | 5 | 31 | |
| GSE74704 | PINK1 | 65018 | 0 | 0 | 20 | |
| TCGA | PINK1 | 65018 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of PINK1:
Generating mutation plots.
Highly correlated genes for PINK1:
Showing top 20/1514 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PINK1 | CRYL1 | 0.852181 | 8 | 0 | 8 |
| PINK1 | PDCD7 | 0.828508 | 4 | 0 | 4 |
| PINK1 | KIAA1191 | 0.818006 | 4 | 0 | 4 |
| PINK1 | TMEM114 | 0.80486 | 3 | 0 | 3 |
| PINK1 | ANO10 | 0.799455 | 9 | 0 | 9 |
| PINK1 | PPM1L | 0.79694 | 3 | 0 | 3 |
| PINK1 | ATL1 | 0.790661 | 3 | 0 | 3 |
| PINK1 | DTWD1 | 0.788037 | 3 | 0 | 3 |
| PINK1 | KAT2B | 0.787748 | 10 | 0 | 10 |
| PINK1 | COMMD1 | 0.786258 | 4 | 0 | 3 |
| PINK1 | EEPD1 | 0.779263 | 3 | 0 | 3 |
| PINK1 | PPP1R3C | 0.776618 | 10 | 0 | 10 |
| PINK1 | RC3H1 | 0.77422 | 4 | 0 | 4 |
| PINK1 | TJP1 | 0.769605 | 9 | 0 | 9 |
| PINK1 | PDLIM2 | 0.768183 | 10 | 0 | 10 |
| PINK1 | SNORA68 | 0.768025 | 4 | 0 | 4 |
| PINK1 | SLAIN2 | 0.764328 | 3 | 0 | 3 |
| PINK1 | CNOT4 | 0.764074 | 4 | 0 | 4 |
| PINK1 | ACOX3 | 0.764054 | 8 | 0 | 8 |
| PINK1 | REEP5 | 0.763426 | 3 | 0 | 3 |
For details and further investigation, click here
