| Full name: acetyl-CoA acyltransferase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 30 | HGNC ID: HGNC:82 | Ensembl Gene: ENSG00000060971 | OMIM ID: 604054 |
| Drug and gene relationship at DGIdb | |||
ACAA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of ACAA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACAA1 | 30 | 214274_s_at | -0.4860 | 0.4516 | |
| GSE20347 | ACAA1 | 30 | 214274_s_at | -1.6107 | 0.0000 | |
| GSE23400 | ACAA1 | 30 | 202025_x_at | -0.7881 | 0.0000 | |
| GSE26886 | ACAA1 | 30 | 214274_s_at | -1.7588 | 0.0000 | |
| GSE29001 | ACAA1 | 30 | 214274_s_at | -1.5722 | 0.0000 | |
| GSE38129 | ACAA1 | 30 | 214274_s_at | -1.3177 | 0.0000 | |
| GSE45670 | ACAA1 | 30 | 214274_s_at | -0.4710 | 0.0451 | |
| GSE63941 | ACAA1 | 30 | 214274_s_at | -1.4303 | 0.0058 | |
| GSE77861 | ACAA1 | 30 | 214274_s_at | -1.2651 | 0.0009 | |
| GSE97050 | ACAA1 | 30 | A_23_P69339 | -0.5058 | 0.1745 | |
| SRP007169 | ACAA1 | 30 | RNAseq | -2.9148 | 0.0000 | |
| SRP008496 | ACAA1 | 30 | RNAseq | -2.6405 | 0.0000 | |
| SRP064894 | ACAA1 | 30 | RNAseq | -1.3062 | 0.0000 | |
| SRP133303 | ACAA1 | 30 | RNAseq | -1.3666 | 0.0000 | |
| SRP159526 | ACAA1 | 30 | RNAseq | -1.4360 | 0.0000 | |
| SRP193095 | ACAA1 | 30 | RNAseq | -1.6505 | 0.0000 | |
| SRP219564 | ACAA1 | 30 | RNAseq | -1.2469 | 0.0031 | |
| TCGA | ACAA1 | 30 | RNAseq | -0.3170 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by ACAA1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ACAA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACAA1 | 30 | 0 | 19 | 11 | |
| GSE20123 | ACAA1 | 30 | 0 | 19 | 11 | |
| GSE43470 | ACAA1 | 30 | 0 | 20 | 23 | |
| GSE46452 | ACAA1 | 30 | 2 | 17 | 40 | |
| GSE47630 | ACAA1 | 30 | 1 | 25 | 14 | |
| GSE54993 | ACAA1 | 30 | 6 | 3 | 61 | |
| GSE54994 | ACAA1 | 30 | 1 | 33 | 19 | |
| GSE60625 | ACAA1 | 30 | 5 | 0 | 6 | |
| GSE74703 | ACAA1 | 30 | 0 | 16 | 20 | |
| GSE74704 | ACAA1 | 30 | 0 | 13 | 7 | |
| TCGA | ACAA1 | 30 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of ACAA1:
Generating mutation plots.
Highly correlated genes for ACAA1:
Showing top 20/1600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACAA1 | RAB5A | 0.865548 | 9 | 0 | 9 |
| ACAA1 | RAB11A | 0.854487 | 8 | 0 | 8 |
| ACAA1 | SLC16A6 | 0.853437 | 9 | 0 | 9 |
| ACAA1 | ACOX3 | 0.850672 | 9 | 0 | 9 |
| ACAA1 | CWH43 | 0.842827 | 8 | 0 | 8 |
| ACAA1 | SORT1 | 0.83983 | 8 | 0 | 8 |
| ACAA1 | PITHD1 | 0.839318 | 4 | 0 | 4 |
| ACAA1 | PDCD6IP | 0.834318 | 9 | 0 | 9 |
| ACAA1 | SCNN1B | 0.834199 | 8 | 0 | 8 |
| ACAA1 | CYP2J2 | 0.831502 | 8 | 0 | 8 |
| ACAA1 | TAB3 | 0.830662 | 4 | 0 | 4 |
| ACAA1 | GPD1L | 0.824762 | 8 | 0 | 8 |
| ACAA1 | VSIG10L | 0.821564 | 4 | 0 | 4 |
| ACAA1 | SFTA2 | 0.817802 | 4 | 0 | 4 |
| ACAA1 | CGNL1 | 0.817615 | 4 | 0 | 4 |
| ACAA1 | GYS2 | 0.815891 | 8 | 0 | 8 |
| ACAA1 | HPGD | 0.81438 | 8 | 0 | 8 |
| ACAA1 | SASH1 | 0.812397 | 10 | 0 | 10 |
| ACAA1 | C18orf25 | 0.807923 | 9 | 0 | 9 |
| ACAA1 | C5orf66-AS1 | 0.807621 | 4 | 0 | 4 |
For details and further investigation, click here
