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Multi-Omics Database of ESCC

 

PNLDC1

 

Full name: PARN like, ribonuclease domain containing 1 Alias Symbol: FLJ40240|dJ195P10.2
Type: protein-coding gene Cytoband: 6q25.3
Entrez ID: 154197 HGNC ID: HGNC:21185 Ensembl Gene: ENSG00000146453 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of PNLDC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PNLDC1 154197 1564414_a_at 2.6806 0.2059
GSE26886 PNLDC1 154197 1564414_a_at 0.5151 0.2240
GSE45670 PNLDC1 154197 1564414_a_at 1.0820 0.1159
GSE53622 PNLDC1 154197 49324 1.5607 0.0001
GSE53624 PNLDC1 154197 49324 1.2069 0.0000
GSE63941 PNLDC1 154197 1564414_a_at 0.1639 0.8228
GSE77861 PNLDC1 154197 1564414_a_at 0.3554 0.5444
GSE97050 PNLDC1 154197 A_23_P323243 0.6111 0.4121
TCGA PNLDC1 154197 RNAseq 3.2368 0.0007

Upregulated datasets: 3; Downregulated datasets: 0.  


 

Survival by PNLDC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of PNLDC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PNLDC1 154197 1 5 24
GSE20123 PNLDC1 154197 1 4 25
GSE43470 PNLDC1 154197 4 0 39
GSE46452 PNLDC1 154197 3 10 46
GSE47630 PNLDC1 154197 9 4 27
GSE54993 PNLDC1 154197 3 2 65
GSE54994 PNLDC1 154197 8 8 37
GSE60625 PNLDC1 154197 0 1 10
GSE74703 PNLDC1 154197 4 0 32
GSE74704 PNLDC1 154197 0 2 18
TCGA PNLDC1 154197 13 22 61

Total number of gains: 46; Total number of losses: 58; Total Number of normals: 384.  


 

Somatic mutations of PNLDC1:

 

Generating mutation plots.

 

Highly correlated genes for PNLDC1:

 

Showing all 19 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PNLDC1PODXL20.750795303
PNLDC1SCN2A0.725298303
PNLDC1FABP60.683738404
PNLDC1SYCP20.683351303
PNLDC1RALY0.666008303
PNLDC1NT5C0.661162303
PNLDC1PDRG10.658133403
PNLDC1RNF1520.640223303
PNLDC1GRIN2D0.610825403
PNLDC1KLHL210.596991303
PNLDC1AXIN10.586399303
PNLDC1C8orf820.579411303
PNLDC1ARHGAP390.571271403
PNLDC1KLHL350.565799603
PNLDC1FGF110.528022403
PNLDC1HSD3B70.527462403
PNLDC1ZNF740.522768403
PNLDC1CAPN120.522092404
PNLDC1RNF440.50151403

For details and further investigation, click here