| Full name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Alias Symbol: C(27)-3BETA-HSD|SDR11E3 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 80270 | HGNC ID: HGNC:18324 | Ensembl Gene: ENSG00000099377 | OMIM ID: 607764 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD3B7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD3B7 | 80270 | 222817_at | 0.3673 | 0.1432 | |
| GSE26886 | HSD3B7 | 80270 | 222817_at | 0.1422 | 0.4658 | |
| GSE45670 | HSD3B7 | 80270 | 222817_at | 0.2609 | 0.0750 | |
| GSE53622 | HSD3B7 | 80270 | 94112 | 0.4303 | 0.0001 | |
| GSE53624 | HSD3B7 | 80270 | 94112 | 0.6382 | 0.0000 | |
| GSE63941 | HSD3B7 | 80270 | 222817_at | -0.1334 | 0.8261 | |
| GSE77861 | HSD3B7 | 80270 | 222817_at | 0.0221 | 0.9442 | |
| GSE97050 | HSD3B7 | 80270 | A_33_P3251776 | 0.2104 | 0.6699 | |
| SRP007169 | HSD3B7 | 80270 | RNAseq | 0.7163 | 0.2173 | |
| SRP008496 | HSD3B7 | 80270 | RNAseq | 0.5148 | 0.2237 | |
| SRP064894 | HSD3B7 | 80270 | RNAseq | 1.1241 | 0.0000 | |
| SRP133303 | HSD3B7 | 80270 | RNAseq | 0.5392 | 0.0000 | |
| SRP159526 | HSD3B7 | 80270 | RNAseq | 0.1026 | 0.7077 | |
| SRP193095 | HSD3B7 | 80270 | RNAseq | 0.4824 | 0.0000 | |
| SRP219564 | HSD3B7 | 80270 | RNAseq | 0.7057 | 0.1508 | |
| TCGA | HSD3B7 | 80270 | RNAseq | 0.0303 | 0.7292 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HSD3B7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD3B7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD3B7 | 80270 | 5 | 5 | 20 | |
| GSE20123 | HSD3B7 | 80270 | 5 | 4 | 21 | |
| GSE43470 | HSD3B7 | 80270 | 3 | 3 | 37 | |
| GSE46452 | HSD3B7 | 80270 | 38 | 1 | 20 | |
| GSE47630 | HSD3B7 | 80270 | 11 | 7 | 22 | |
| GSE54993 | HSD3B7 | 80270 | 2 | 5 | 63 | |
| GSE54994 | HSD3B7 | 80270 | 5 | 9 | 39 | |
| GSE60625 | HSD3B7 | 80270 | 4 | 0 | 7 | |
| GSE74703 | HSD3B7 | 80270 | 3 | 2 | 31 | |
| GSE74704 | HSD3B7 | 80270 | 3 | 2 | 15 | |
| TCGA | HSD3B7 | 80270 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of HSD3B7:
Generating mutation plots.
Highly correlated genes for HSD3B7:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD3B7 | LILRB2 | 0.742398 | 5 | 0 | 5 |
| HSD3B7 | CMPK2 | 0.719303 | 4 | 0 | 4 |
| HSD3B7 | CDC42EP1 | 0.715369 | 3 | 0 | 3 |
| HSD3B7 | POFUT1 | 0.693952 | 3 | 0 | 3 |
| HSD3B7 | CD80 | 0.690645 | 3 | 0 | 3 |
| HSD3B7 | SLC15A3 | 0.690266 | 4 | 0 | 4 |
| HSD3B7 | CD14 | 0.688754 | 5 | 0 | 5 |
| HSD3B7 | ZDHHC7 | 0.682743 | 4 | 0 | 4 |
| HSD3B7 | XYLT2 | 0.681671 | 3 | 0 | 3 |
| HSD3B7 | NR1H2 | 0.681262 | 4 | 0 | 4 |
| HSD3B7 | SEL1L | 0.679516 | 3 | 0 | 3 |
| HSD3B7 | CDK18 | 0.679159 | 4 | 0 | 4 |
| HSD3B7 | KTI12 | 0.675853 | 3 | 0 | 3 |
| HSD3B7 | CASK | 0.675784 | 3 | 0 | 3 |
| HSD3B7 | PRKACA | 0.672653 | 4 | 0 | 3 |
| HSD3B7 | KIAA0513 | 0.671682 | 3 | 0 | 3 |
| HSD3B7 | CYC1 | 0.6711 | 3 | 0 | 3 |
| HSD3B7 | BCL9L | 0.671029 | 3 | 0 | 3 |
| HSD3B7 | LY96 | 0.67037 | 5 | 0 | 4 |
| HSD3B7 | CPNE8 | 0.664642 | 4 | 0 | 4 |
For details and further investigation, click here
