| Full name: zinc finger protein 74 | Alias Symbol: Cos52|Zfp520|ZNF520 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 7625 | HGNC ID: HGNC:13144 | Ensembl Gene: ENSG00000185252 | OMIM ID: 194548 |
| Drug and gene relationship at DGIdb | |||
Expression of ZNF74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF74 | 7625 | 235997_at | 0.3726 | 0.2454 | |
| GSE20347 | ZNF74 | 7625 | 205881_at | 0.3896 | 0.0014 | |
| GSE23400 | ZNF74 | 7625 | 205881_at | 0.2232 | 0.0000 | |
| GSE26886 | ZNF74 | 7625 | 235997_at | 0.2866 | 0.1157 | |
| GSE29001 | ZNF74 | 7625 | 205881_at | 0.5663 | 0.0065 | |
| GSE38129 | ZNF74 | 7625 | 205881_at | 0.5412 | 0.0000 | |
| GSE45670 | ZNF74 | 7625 | 235997_at | 0.2061 | 0.0551 | |
| GSE53622 | ZNF74 | 7625 | 38062 | 0.4208 | 0.0001 | |
| GSE53624 | ZNF74 | 7625 | 38062 | 0.6663 | 0.0000 | |
| GSE63941 | ZNF74 | 7625 | 235997_at | 0.5359 | 0.0710 | |
| GSE77861 | ZNF74 | 7625 | 205881_at | 0.0966 | 0.6265 | |
| GSE97050 | ZNF74 | 7625 | A_33_P3291636 | -0.0639 | 0.8496 | |
| SRP007169 | ZNF74 | 7625 | RNAseq | 0.9194 | 0.0496 | |
| SRP008496 | ZNF74 | 7625 | RNAseq | 1.0872 | 0.0014 | |
| SRP064894 | ZNF74 | 7625 | RNAseq | 0.8232 | 0.0001 | |
| SRP133303 | ZNF74 | 7625 | RNAseq | 0.3576 | 0.0310 | |
| SRP159526 | ZNF74 | 7625 | RNAseq | 0.9545 | 0.0268 | |
| SRP193095 | ZNF74 | 7625 | RNAseq | 0.4502 | 0.0000 | |
| SRP219564 | ZNF74 | 7625 | RNAseq | 1.0486 | 0.0010 | |
| TCGA | ZNF74 | 7625 | RNAseq | 0.1888 | 0.0096 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ZNF74 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF74 | 7625 | 5 | 7 | 18 | |
| GSE20123 | ZNF74 | 7625 | 5 | 7 | 18 | |
| GSE43470 | ZNF74 | 7625 | 4 | 7 | 32 | |
| GSE46452 | ZNF74 | 7625 | 33 | 1 | 25 | |
| GSE47630 | ZNF74 | 7625 | 8 | 5 | 27 | |
| GSE54993 | ZNF74 | 7625 | 3 | 6 | 61 | |
| GSE54994 | ZNF74 | 7625 | 11 | 8 | 34 | |
| GSE60625 | ZNF74 | 7625 | 5 | 0 | 6 | |
| GSE74703 | ZNF74 | 7625 | 4 | 5 | 27 | |
| GSE74704 | ZNF74 | 7625 | 3 | 4 | 13 | |
| TCGA | ZNF74 | 7625 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 67; Total Number of normals: 313.
Somatic mutations of ZNF74:
Generating mutation plots.
Highly correlated genes for ZNF74:
Showing top 20/827 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF74 | CSNK1D | 0.7161 | 4 | 0 | 3 |
| ZNF74 | LRRC41 | 0.714253 | 4 | 0 | 3 |
| ZNF74 | FN3K | 0.708863 | 3 | 0 | 3 |
| ZNF74 | GNA11 | 0.705579 | 3 | 0 | 3 |
| ZNF74 | GYS1 | 0.696029 | 3 | 0 | 3 |
| ZNF74 | ZNF251 | 0.695999 | 3 | 0 | 3 |
| ZNF74 | THAP5 | 0.689973 | 3 | 0 | 3 |
| ZNF74 | CCDC124 | 0.689459 | 4 | 0 | 4 |
| ZNF74 | CTXN1 | 0.687892 | 4 | 0 | 3 |
| ZNF74 | ZNF408 | 0.687633 | 3 | 0 | 3 |
| ZNF74 | MAP1S | 0.683863 | 4 | 0 | 3 |
| ZNF74 | B9D2 | 0.682581 | 3 | 0 | 3 |
| ZNF74 | PIK3R3 | 0.678262 | 4 | 0 | 3 |
| ZNF74 | MYPOP | 0.674705 | 4 | 0 | 4 |
| ZNF74 | DGCR8 | 0.673811 | 3 | 0 | 3 |
| ZNF74 | RBM4B | 0.672815 | 4 | 0 | 4 |
| ZNF74 | GABRQ | 0.671224 | 3 | 0 | 3 |
| ZNF74 | MFN2 | 0.670857 | 3 | 0 | 3 |
| ZNF74 | TP53I11 | 0.670509 | 3 | 0 | 3 |
| ZNF74 | ZNF558 | 0.668202 | 6 | 0 | 6 |
For details and further investigation, click here
