| Full name: sodium voltage-gated channel alpha subunit 2 | Alias Symbol: Nav1.2|HBSCII|HBSCI | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 6326 | HGNC ID: HGNC:10588 | Ensembl Gene: ENSG00000136531 | OMIM ID: 182390 |
| Drug and gene relationship at DGIdb | |||
SCN2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction |
Expression of SCN2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN2A | 6326 | 206381_at | 0.6280 | 0.3970 | |
| GSE20347 | SCN2A | 6326 | 206381_at | 0.0542 | 0.6460 | |
| GSE23400 | SCN2A | 6326 | 206381_at | -0.0777 | 0.1433 | |
| GSE26886 | SCN2A | 6326 | 206381_at | 0.2965 | 0.1889 | |
| GSE29001 | SCN2A | 6326 | 206381_at | 0.4831 | 0.0315 | |
| GSE38129 | SCN2A | 6326 | 206381_at | -0.0221 | 0.9385 | |
| GSE45670 | SCN2A | 6326 | 206381_at | 0.4008 | 0.1892 | |
| GSE53622 | SCN2A | 6326 | 67919 | 0.8080 | 0.0004 | |
| GSE53624 | SCN2A | 6326 | 67919 | 1.1115 | 0.0000 | |
| GSE63941 | SCN2A | 6326 | 206381_at | -1.1971 | 0.0185 | |
| GSE77861 | SCN2A | 6326 | 206381_at | -0.1399 | 0.3042 | |
| GSE97050 | SCN2A | 6326 | A_23_P51019 | 0.4564 | 0.3377 | |
| SRP133303 | SCN2A | 6326 | RNAseq | 3.0032 | 0.0000 | |
| TCGA | SCN2A | 6326 | RNAseq | -0.8256 | 0.1043 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SCN2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN2A | 6326 | 5 | 1 | 24 | |
| GSE20123 | SCN2A | 6326 | 5 | 1 | 24 | |
| GSE43470 | SCN2A | 6326 | 5 | 1 | 37 | |
| GSE46452 | SCN2A | 6326 | 1 | 4 | 54 | |
| GSE47630 | SCN2A | 6326 | 5 | 3 | 32 | |
| GSE54993 | SCN2A | 6326 | 0 | 5 | 65 | |
| GSE54994 | SCN2A | 6326 | 11 | 2 | 40 | |
| GSE60625 | SCN2A | 6326 | 0 | 3 | 8 | |
| GSE74703 | SCN2A | 6326 | 4 | 1 | 31 | |
| GSE74704 | SCN2A | 6326 | 3 | 0 | 17 | |
| TCGA | SCN2A | 6326 | 25 | 8 | 63 |
Total number of gains: 64; Total number of losses: 29; Total Number of normals: 395.
Somatic mutations of SCN2A:
Generating mutation plots.
Highly correlated genes for SCN2A:
Showing top 20/92 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN2A | KLK14 | 0.728197 | 3 | 0 | 3 |
| SCN2A | PNLDC1 | 0.725298 | 3 | 0 | 3 |
| SCN2A | NOL4 | 0.703887 | 3 | 0 | 3 |
| SCN2A | TMEM120B | 0.670029 | 3 | 0 | 3 |
| SCN2A | SCGB1A1 | 0.65372 | 3 | 0 | 3 |
| SCN2A | TRAPPC9 | 0.638229 | 4 | 0 | 4 |
| SCN2A | RET | 0.637007 | 3 | 0 | 3 |
| SCN2A | TEX13A | 0.634184 | 3 | 0 | 3 |
| SCN2A | ZDHHC22 | 0.631046 | 4 | 0 | 4 |
| SCN2A | TLR6 | 0.627299 | 3 | 0 | 3 |
| SCN2A | MBD6 | 0.623371 | 3 | 0 | 3 |
| SCN2A | ARHGAP33 | 0.623262 | 4 | 0 | 3 |
| SCN2A | RALYL | 0.621628 | 4 | 0 | 3 |
| SCN2A | GLIPR1L1 | 0.620529 | 3 | 0 | 3 |
| SCN2A | POLL | 0.610214 | 4 | 0 | 3 |
| SCN2A | TMCO2 | 0.604402 | 3 | 0 | 3 |
| SCN2A | PON1 | 0.603862 | 4 | 0 | 3 |
| SCN2A | SCN3A | 0.602211 | 4 | 0 | 3 |
| SCN2A | FAM83E | 0.598651 | 4 | 0 | 3 |
| SCN2A | FGA | 0.598459 | 4 | 0 | 3 |
For details and further investigation, click here
