| Full name: 5', 3'-nucleotidase, cytosolic | Alias Symbol: DNT1|DNT-1|PN-I|cdN|dNT-1 | ||
| Type: protein-coding gene | Cytoband: 17q25 | ||
| Entrez ID: 30833 | HGNC ID: HGNC:17144 | Ensembl Gene: ENSG00000125458 | OMIM ID: 191720 |
| Drug and gene relationship at DGIdb | |||
Expression of NT5C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NT5C | 30833 | 1557303_at | 0.0446 | 0.8810 | |
| GSE26886 | NT5C | 30833 | 1557303_at | -0.0419 | 0.6651 | |
| GSE45670 | NT5C | 30833 | 1557303_at | 0.2437 | 0.1820 | |
| GSE53622 | NT5C | 30833 | 36101 | 0.1979 | 0.0014 | |
| GSE53624 | NT5C | 30833 | 36101 | 0.4173 | 0.0000 | |
| GSE63941 | NT5C | 30833 | 1557303_at | 0.3002 | 0.2854 | |
| GSE77861 | NT5C | 30833 | 1557303_at | 0.0187 | 0.9200 | |
| GSE97050 | NT5C | 30833 | A_33_P3229256 | 0.2394 | 0.3319 | |
| SRP007169 | NT5C | 30833 | RNAseq | -0.1503 | 0.7231 | |
| SRP008496 | NT5C | 30833 | RNAseq | 0.2425 | 0.4240 | |
| SRP064894 | NT5C | 30833 | RNAseq | 0.8177 | 0.0082 | |
| SRP133303 | NT5C | 30833 | RNAseq | 0.4202 | 0.0358 | |
| SRP159526 | NT5C | 30833 | RNAseq | 0.1557 | 0.4451 | |
| SRP193095 | NT5C | 30833 | RNAseq | 0.0685 | 0.6240 | |
| SRP219564 | NT5C | 30833 | RNAseq | 0.8771 | 0.1258 | |
| TCGA | NT5C | 30833 | RNAseq | 0.1338 | 0.0572 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NT5C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NT5C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NT5C | 30833 | 6 | 2 | 22 | |
| GSE20123 | NT5C | 30833 | 6 | 2 | 22 | |
| GSE43470 | NT5C | 30833 | 5 | 3 | 35 | |
| GSE46452 | NT5C | 30833 | 33 | 0 | 26 | |
| GSE47630 | NT5C | 30833 | 8 | 1 | 31 | |
| GSE54993 | NT5C | 30833 | 2 | 5 | 63 | |
| GSE54994 | NT5C | 30833 | 10 | 4 | 39 | |
| GSE60625 | NT5C | 30833 | 6 | 0 | 5 | |
| GSE74703 | NT5C | 30833 | 5 | 1 | 30 | |
| GSE74704 | NT5C | 30833 | 4 | 1 | 15 | |
| TCGA | NT5C | 30833 | 32 | 10 | 54 |
Total number of gains: 117; Total number of losses: 29; Total Number of normals: 342.
Somatic mutations of NT5C:
Generating mutation plots.
Highly correlated genes for NT5C:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NT5C | KIF22 | 0.739367 | 3 | 0 | 3 |
| NT5C | PNLDC1 | 0.661162 | 3 | 0 | 3 |
| NT5C | NCAPD2 | 0.652563 | 3 | 0 | 3 |
| NT5C | STK31 | 0.629418 | 3 | 0 | 3 |
| NT5C | TMEM14A | 0.629103 | 4 | 0 | 3 |
| NT5C | NUFIP1 | 0.623358 | 3 | 0 | 3 |
| NT5C | NDUFB9 | 0.619996 | 4 | 0 | 3 |
| NT5C | PUS7 | 0.616398 | 4 | 0 | 3 |
| NT5C | B4GALT7 | 0.612922 | 3 | 0 | 3 |
| NT5C | NUP85 | 0.612693 | 4 | 0 | 3 |
| NT5C | ANGEL1 | 0.606418 | 4 | 0 | 3 |
| NT5C | GSS | 0.601859 | 5 | 0 | 3 |
| NT5C | HDGF | 0.592279 | 4 | 0 | 3 |
| NT5C | SPAG5 | 0.590809 | 4 | 0 | 3 |
| NT5C | TAZ | 0.586097 | 3 | 0 | 3 |
| NT5C | EIF2B2 | 0.581255 | 3 | 0 | 3 |
| NT5C | MYO19 | 0.578067 | 4 | 0 | 4 |
| NT5C | C16orf74 | 0.577981 | 4 | 0 | 3 |
| NT5C | AURKB | 0.576602 | 4 | 0 | 3 |
| NT5C | FOXS1 | 0.575465 | 3 | 0 | 3 |
For details and further investigation, click here
