| Full name: pinin, desmosome associated protein | Alias Symbol: memA | ||
| Type: protein-coding gene | Cytoband: 14q21.1 | ||
| Entrez ID: 5411 | HGNC ID: HGNC:9162 | Ensembl Gene: ENSG00000100941 | OMIM ID: 603154 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PNN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNN | 5411 | 210183_x_at | -0.0170 | 0.9611 | |
| GSE20347 | PNN | 5411 | 210183_x_at | -0.1346 | 0.0605 | |
| GSE23400 | PNN | 5411 | 210183_x_at | -0.1036 | 0.0266 | |
| GSE26886 | PNN | 5411 | 210183_x_at | 0.3285 | 0.0976 | |
| GSE29001 | PNN | 5411 | 210183_x_at | -0.2218 | 0.2952 | |
| GSE38129 | PNN | 5411 | 210183_x_at | -0.0396 | 0.5457 | |
| GSE45670 | PNN | 5411 | 210183_x_at | -0.1174 | 0.2940 | |
| GSE53622 | PNN | 5411 | 23309 | 0.3458 | 0.0000 | |
| GSE53624 | PNN | 5411 | 23309 | 0.3927 | 0.0000 | |
| GSE63941 | PNN | 5411 | 210183_x_at | -0.3803 | 0.2224 | |
| GSE77861 | PNN | 5411 | 210183_x_at | -0.1797 | 0.3365 | |
| GSE97050 | PNN | 5411 | A_33_P3218694 | 0.0787 | 0.7192 | |
| SRP007169 | PNN | 5411 | RNAseq | 1.7305 | 0.0017 | |
| SRP008496 | PNN | 5411 | RNAseq | 1.2500 | 0.0019 | |
| SRP064894 | PNN | 5411 | RNAseq | 0.2914 | 0.2004 | |
| SRP133303 | PNN | 5411 | RNAseq | 0.7316 | 0.0306 | |
| SRP159526 | PNN | 5411 | RNAseq | 0.3343 | 0.3194 | |
| SRP193095 | PNN | 5411 | RNAseq | 0.4237 | 0.0074 | |
| SRP219564 | PNN | 5411 | RNAseq | 0.5411 | 0.1859 | |
| TCGA | PNN | 5411 | RNAseq | 0.0372 | 0.4053 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PNN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNN | 5411 | 9 | 5 | 16 | |
| GSE20123 | PNN | 5411 | 9 | 5 | 16 | |
| GSE43470 | PNN | 5411 | 9 | 3 | 31 | |
| GSE46452 | PNN | 5411 | 18 | 2 | 39 | |
| GSE47630 | PNN | 5411 | 11 | 10 | 19 | |
| GSE54993 | PNN | 5411 | 3 | 9 | 58 | |
| GSE54994 | PNN | 5411 | 19 | 5 | 29 | |
| GSE60625 | PNN | 5411 | 0 | 2 | 9 | |
| GSE74703 | PNN | 5411 | 8 | 3 | 25 | |
| GSE74704 | PNN | 5411 | 4 | 3 | 13 | |
| TCGA | PNN | 5411 | 35 | 13 | 48 |
Total number of gains: 125; Total number of losses: 60; Total Number of normals: 303.
Somatic mutations of PNN:
Generating mutation plots.
Highly correlated genes for PNN:
Showing top 20/116 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNN | PNKD | 0.785719 | 3 | 0 | 3 |
| PNN | TAF10 | 0.772322 | 3 | 0 | 3 |
| PNN | RSBN1 | 0.75488 | 3 | 0 | 3 |
| PNN | GLUD1 | 0.737224 | 4 | 0 | 3 |
| PNN | CYB5RL | 0.730203 | 3 | 0 | 3 |
| PNN | ZBTB12 | 0.711241 | 3 | 0 | 3 |
| PNN | C22orf31 | 0.710341 | 3 | 0 | 3 |
| PNN | ZNF747 | 0.691268 | 3 | 0 | 3 |
| PNN | PTPRU | 0.685552 | 3 | 0 | 3 |
| PNN | TSPAN3 | 0.680926 | 4 | 0 | 3 |
| PNN | UXT | 0.679725 | 5 | 0 | 3 |
| PNN | TRIM68 | 0.675071 | 3 | 0 | 3 |
| PNN | BNIP1 | 0.675011 | 3 | 0 | 3 |
| PNN | PSMD9 | 0.674133 | 3 | 0 | 3 |
| PNN | MCCC1 | 0.674025 | 4 | 0 | 3 |
| PNN | STUB1 | 0.672296 | 3 | 0 | 3 |
| PNN | PTDSS2 | 0.672189 | 3 | 0 | 3 |
| PNN | ABHD2 | 0.671251 | 3 | 0 | 3 |
| PNN | C9orf16 | 0.671221 | 4 | 0 | 3 |
| PNN | ROMO1 | 0.670255 | 3 | 0 | 3 |
For details and further investigation, click here
