| Full name: methylcrotonoyl-CoA carboxylase 1 | Alias Symbol: MCCA | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 56922 | HGNC ID: HGNC:6936 | Ensembl Gene: ENSG00000078070 | OMIM ID: 609010 |
| Drug and gene relationship at DGIdb | |||
Expression of MCCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCCC1 | 56922 | 218440_at | 0.1054 | 0.8845 | |
| GSE20347 | MCCC1 | 56922 | 218440_at | 0.1097 | 0.6030 | |
| GSE23400 | MCCC1 | 56922 | 218440_at | 0.1358 | 0.1784 | |
| GSE26886 | MCCC1 | 56922 | 218440_at | -0.0182 | 0.9632 | |
| GSE29001 | MCCC1 | 56922 | 218440_at | -0.0456 | 0.9195 | |
| GSE38129 | MCCC1 | 56922 | 218440_at | 0.1702 | 0.3262 | |
| GSE45670 | MCCC1 | 56922 | 218440_at | -0.0871 | 0.7953 | |
| GSE53622 | MCCC1 | 56922 | 62486 | -0.0333 | 0.8116 | |
| GSE53624 | MCCC1 | 56922 | 62486 | -0.0578 | 0.4211 | |
| GSE63941 | MCCC1 | 56922 | 218440_at | 1.1880 | 0.1106 | |
| GSE77861 | MCCC1 | 56922 | 218440_at | -0.1957 | 0.5727 | |
| GSE97050 | MCCC1 | 56922 | A_23_P58036 | -0.2641 | 0.2920 | |
| SRP007169 | MCCC1 | 56922 | RNAseq | 0.5655 | 0.3621 | |
| SRP008496 | MCCC1 | 56922 | RNAseq | 0.2996 | 0.4499 | |
| SRP064894 | MCCC1 | 56922 | RNAseq | -0.1093 | 0.5815 | |
| SRP133303 | MCCC1 | 56922 | RNAseq | 0.0784 | 0.7366 | |
| SRP159526 | MCCC1 | 56922 | RNAseq | 0.9964 | 0.0005 | |
| SRP193095 | MCCC1 | 56922 | RNAseq | -0.0891 | 0.5115 | |
| SRP219564 | MCCC1 | 56922 | RNAseq | -0.4702 | 0.0648 | |
| TCGA | MCCC1 | 56922 | RNAseq | -0.0564 | 0.4719 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MCCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCCC1 | 56922 | 25 | 0 | 5 | |
| GSE20123 | MCCC1 | 56922 | 25 | 0 | 5 | |
| GSE43470 | MCCC1 | 56922 | 24 | 0 | 19 | |
| GSE46452 | MCCC1 | 56922 | 19 | 1 | 39 | |
| GSE47630 | MCCC1 | 56922 | 27 | 2 | 11 | |
| GSE54993 | MCCC1 | 56922 | 1 | 19 | 50 | |
| GSE54994 | MCCC1 | 56922 | 41 | 0 | 12 | |
| GSE60625 | MCCC1 | 56922 | 0 | 6 | 5 | |
| GSE74703 | MCCC1 | 56922 | 20 | 0 | 16 | |
| GSE74704 | MCCC1 | 56922 | 17 | 0 | 3 | |
| TCGA | MCCC1 | 56922 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of MCCC1:
Generating mutation plots.
Highly correlated genes for MCCC1:
Showing top 20/288 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCCC1 | LCOR | 0.806686 | 3 | 0 | 3 |
| MCCC1 | UPF1 | 0.784705 | 3 | 0 | 3 |
| MCCC1 | PANK4 | 0.770473 | 3 | 0 | 3 |
| MCCC1 | TAF7 | 0.762888 | 3 | 0 | 3 |
| MCCC1 | TXNDC16 | 0.755303 | 3 | 0 | 3 |
| MCCC1 | ZNF564 | 0.754727 | 3 | 0 | 3 |
| MCCC1 | POP5 | 0.753073 | 3 | 0 | 3 |
| MCCC1 | NDUFA11 | 0.751581 | 3 | 0 | 3 |
| MCCC1 | MED4 | 0.750624 | 3 | 0 | 3 |
| MCCC1 | TMEM219 | 0.738054 | 3 | 0 | 3 |
| MCCC1 | NCOR1 | 0.73144 | 3 | 0 | 3 |
| MCCC1 | DMTF1 | 0.727673 | 3 | 0 | 3 |
| MCCC1 | SSNA1 | 0.723529 | 3 | 0 | 3 |
| MCCC1 | ZACN | 0.721946 | 3 | 0 | 3 |
| MCCC1 | OTUD7B | 0.718327 | 3 | 0 | 3 |
| MCCC1 | ZNF586 | 0.714425 | 3 | 0 | 3 |
| MCCC1 | CS | 0.71267 | 3 | 0 | 3 |
| MCCC1 | ZNF317 | 0.711183 | 3 | 0 | 3 |
| MCCC1 | VPS36 | 0.708894 | 3 | 0 | 3 |
| MCCC1 | ERGIC2 | 0.705448 | 3 | 0 | 3 |
For details and further investigation, click here
