| Full name: SEC13 homolog, nuclear pore and COPII coat complex component | Alias Symbol: SEC13R|npp-20 | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 6396 | HGNC ID: HGNC:10697 | Ensembl Gene: ENSG00000157020 | OMIM ID: 600152 |
| Drug and gene relationship at DGIdb | |||
SEC13 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of SEC13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC13 | 6396 | 207707_s_at | -0.0592 | 0.8820 | |
| GSE20347 | SEC13 | 6396 | 207707_s_at | -0.4193 | 0.0045 | |
| GSE23400 | SEC13 | 6396 | 207707_s_at | -0.0671 | 0.1449 | |
| GSE26886 | SEC13 | 6396 | 207707_s_at | -0.9434 | 0.0000 | |
| GSE29001 | SEC13 | 6396 | 207707_s_at | -0.4011 | 0.1672 | |
| GSE38129 | SEC13 | 6396 | 207707_s_at | -0.2077 | 0.0900 | |
| GSE45670 | SEC13 | 6396 | 207707_s_at | -0.0637 | 0.5737 | |
| GSE53622 | SEC13 | 6396 | 126039 | 0.0328 | 0.5943 | |
| GSE53624 | SEC13 | 6396 | 126039 | -0.0898 | 0.2937 | |
| GSE63941 | SEC13 | 6396 | 207707_s_at | -0.9531 | 0.0517 | |
| GSE77861 | SEC13 | 6396 | 207707_s_at | -0.3070 | 0.0741 | |
| GSE97050 | SEC13 | 6396 | A_33_P3210900 | 0.3425 | 0.3584 | |
| SRP008496 | SEC13 | 6396 | RNAseq | -0.7296 | 0.0014 | |
| SRP064894 | SEC13 | 6396 | RNAseq | 0.0566 | 0.7720 | |
| SRP133303 | SEC13 | 6396 | RNAseq | 0.2105 | 0.2021 | |
| SRP159526 | SEC13 | 6396 | RNAseq | -0.2927 | 0.2284 | |
| SRP193095 | SEC13 | 6396 | RNAseq | -0.4218 | 0.0021 | |
| SRP219564 | SEC13 | 6396 | RNAseq | 0.0620 | 0.7946 | |
| TCGA | SEC13 | 6396 | RNAseq | -0.0671 | 0.1847 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC13 | 6396 | 1 | 18 | 11 | |
| GSE20123 | SEC13 | 6396 | 1 | 18 | 11 | |
| GSE43470 | SEC13 | 6396 | 1 | 20 | 22 | |
| GSE46452 | SEC13 | 6396 | 2 | 17 | 40 | |
| GSE47630 | SEC13 | 6396 | 2 | 23 | 15 | |
| GSE54993 | SEC13 | 6396 | 6 | 1 | 63 | |
| GSE54994 | SEC13 | 6396 | 3 | 31 | 19 | |
| GSE60625 | SEC13 | 6396 | 5 | 0 | 6 | |
| GSE74703 | SEC13 | 6396 | 1 | 16 | 19 | |
| GSE74704 | SEC13 | 6396 | 1 | 10 | 9 | |
| TCGA | SEC13 | 6396 | 4 | 66 | 26 |
Total number of gains: 27; Total number of losses: 220; Total Number of normals: 241.
Somatic mutations of SEC13:
Generating mutation plots.
Highly correlated genes for SEC13:
Showing top 20/262 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC13 | NT5C1A | 0.789971 | 3 | 0 | 3 |
| SEC13 | GPR78 | 0.770034 | 3 | 0 | 3 |
| SEC13 | KCNT1 | 0.769789 | 3 | 0 | 3 |
| SEC13 | PHLDB3 | 0.73225 | 3 | 0 | 3 |
| SEC13 | TMEM37 | 0.726484 | 3 | 0 | 3 |
| SEC13 | PNPLA5 | 0.722039 | 3 | 0 | 3 |
| SEC13 | GALR2 | 0.715457 | 3 | 0 | 3 |
| SEC13 | ANKFN1 | 0.71024 | 3 | 0 | 3 |
| SEC13 | HECTD1 | 0.706441 | 3 | 0 | 3 |
| SEC13 | RGS12 | 0.703844 | 3 | 0 | 3 |
| SEC13 | KLHL10 | 0.702803 | 3 | 0 | 3 |
| SEC13 | CAPN14 | 0.689247 | 3 | 0 | 3 |
| SEC13 | ERBB2 | 0.684043 | 4 | 0 | 3 |
| SEC13 | TMPRSS11D | 0.680548 | 3 | 0 | 3 |
| SEC13 | SLC5A1 | 0.677705 | 3 | 0 | 3 |
| SEC13 | PRSS2 | 0.670394 | 4 | 0 | 3 |
| SEC13 | KRT32 | 0.670181 | 3 | 0 | 3 |
| SEC13 | ACOT11 | 0.669909 | 3 | 0 | 3 |
| SEC13 | BBOX1 | 0.669139 | 4 | 0 | 4 |
| SEC13 | KCTD5 | 0.666284 | 5 | 0 | 4 |
For details and further investigation, click here
