| Full name: POC1 centriolar protein B | Alias Symbol: TUWD12|FLJ14923 | ||
| Type: protein-coding gene | Cytoband: 12q21.33 | ||
| Entrez ID: 282809 | HGNC ID: HGNC:30836 | Ensembl Gene: ENSG00000139323 | OMIM ID: 614784 |
| Drug and gene relationship at DGIdb | |||
Expression of POC1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POC1B | 282809 | 226283_at | -0.5188 | 0.3529 | |
| GSE26886 | POC1B | 282809 | 226283_at | -0.1459 | 0.4720 | |
| GSE45670 | POC1B | 282809 | 226283_at | -0.0252 | 0.8996 | |
| GSE53622 | POC1B | 282809 | 9855 | -0.3325 | 0.0000 | |
| GSE53624 | POC1B | 282809 | 9855 | -0.2041 | 0.0004 | |
| GSE63941 | POC1B | 282809 | 226283_at | -0.2641 | 0.6222 | |
| GSE77861 | POC1B | 282809 | 226283_at | 0.0598 | 0.7778 | |
| GSE97050 | POC1B | 282809 | A_23_P105535 | 0.1953 | 0.3713 | |
| SRP007169 | POC1B | 282809 | RNAseq | 0.3183 | 0.4877 | |
| SRP008496 | POC1B | 282809 | RNAseq | 0.2251 | 0.3874 | |
| SRP064894 | POC1B | 282809 | RNAseq | -0.1175 | 0.4792 | |
| SRP133303 | POC1B | 282809 | RNAseq | 0.0987 | 0.5550 | |
| SRP159526 | POC1B | 282809 | RNAseq | 0.0498 | 0.8296 | |
| SRP193095 | POC1B | 282809 | RNAseq | -0.1968 | 0.2558 | |
| SRP219564 | POC1B | 282809 | RNAseq | -0.4758 | 0.0052 | |
| TCGA | POC1B | 282809 | RNAseq | -0.1427 | 0.0108 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POC1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POC1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POC1B | 282809 | 3 | 2 | 25 | |
| GSE20123 | POC1B | 282809 | 3 | 2 | 25 | |
| GSE43470 | POC1B | 282809 | 3 | 0 | 40 | |
| GSE46452 | POC1B | 282809 | 9 | 1 | 49 | |
| GSE47630 | POC1B | 282809 | 11 | 1 | 28 | |
| GSE54993 | POC1B | 282809 | 0 | 6 | 64 | |
| GSE54994 | POC1B | 282809 | 6 | 1 | 46 | |
| GSE60625 | POC1B | 282809 | 0 | 0 | 11 | |
| GSE74703 | POC1B | 282809 | 3 | 0 | 33 | |
| GSE74704 | POC1B | 282809 | 1 | 2 | 17 | |
| TCGA | POC1B | 282809 | 19 | 10 | 67 |
Total number of gains: 58; Total number of losses: 25; Total Number of normals: 405.
Somatic mutations of POC1B:
Generating mutation plots.
Highly correlated genes for POC1B:
Showing top 20/22 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POC1B | PLEKHA1 | 0.667667 | 4 | 0 | 3 |
| POC1B | RAD51C | 0.647424 | 3 | 0 | 3 |
| POC1B | FUT10 | 0.614518 | 4 | 0 | 3 |
| POC1B | WDR60 | 0.602341 | 5 | 0 | 3 |
| POC1B | ZNF302 | 0.600936 | 3 | 0 | 3 |
| POC1B | TCEANC | 0.5924 | 4 | 0 | 3 |
| POC1B | BRAF | 0.579016 | 5 | 0 | 4 |
| POC1B | ZNF682 | 0.577614 | 5 | 0 | 4 |
| POC1B | TBC1D9 | 0.57744 | 5 | 0 | 3 |
| POC1B | DHRS7B | 0.575319 | 4 | 0 | 3 |
| POC1B | CYB5R4 | 0.564186 | 4 | 0 | 3 |
| POC1B | CENPC | 0.558154 | 5 | 0 | 3 |
| POC1B | ZFAND4 | 0.556538 | 6 | 0 | 5 |
| POC1B | COQ5 | 0.542554 | 5 | 0 | 3 |
| POC1B | ZBTB6 | 0.541285 | 5 | 0 | 4 |
| POC1B | FBXO4 | 0.539092 | 3 | 0 | 3 |
| POC1B | PPOX | 0.528418 | 4 | 0 | 3 |
| POC1B | NUDT12 | 0.523056 | 4 | 0 | 3 |
| POC1B | ISCU | 0.515394 | 6 | 0 | 4 |
| POC1B | AP5M1 | 0.512036 | 4 | 0 | 3 |
For details and further investigation, click here
