| Full name: cytochrome b5 reductase 4 | Alias Symbol: b5+b5R|dJ676J13.1 | ||
| Type: protein-coding gene | Cytoband: 6q14.2 | ||
| Entrez ID: 51167 | HGNC ID: HGNC:20147 | Ensembl Gene: ENSG00000065615 | OMIM ID: 608343 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CYB5R4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYB5R4 | 51167 | 219079_at | -0.0554 | 0.9494 | |
| GSE20347 | CYB5R4 | 51167 | 219079_at | 0.0171 | 0.9394 | |
| GSE23400 | CYB5R4 | 51167 | 219079_at | 0.2061 | 0.0010 | |
| GSE26886 | CYB5R4 | 51167 | 219079_at | -1.1785 | 0.0004 | |
| GSE29001 | CYB5R4 | 51167 | 219079_at | 0.0355 | 0.9119 | |
| GSE38129 | CYB5R4 | 51167 | 219079_at | 0.0919 | 0.5598 | |
| GSE45670 | CYB5R4 | 51167 | 219079_at | 0.2670 | 0.0082 | |
| GSE53622 | CYB5R4 | 51167 | 68834 | 0.0350 | 0.7032 | |
| GSE53624 | CYB5R4 | 51167 | 68834 | -0.1275 | 0.1497 | |
| GSE63941 | CYB5R4 | 51167 | 219079_at | -0.3130 | 0.5478 | |
| GSE77861 | CYB5R4 | 51167 | 219079_at | 0.2316 | 0.6538 | |
| GSE97050 | CYB5R4 | 51167 | A_23_P30995 | 0.4935 | 0.1556 | |
| SRP007169 | CYB5R4 | 51167 | RNAseq | 0.2711 | 0.4375 | |
| SRP008496 | CYB5R4 | 51167 | RNAseq | 0.2430 | 0.3818 | |
| SRP064894 | CYB5R4 | 51167 | RNAseq | 0.1662 | 0.4102 | |
| SRP133303 | CYB5R4 | 51167 | RNAseq | 0.2396 | 0.0021 | |
| SRP159526 | CYB5R4 | 51167 | RNAseq | -0.1323 | 0.7166 | |
| SRP193095 | CYB5R4 | 51167 | RNAseq | 0.1391 | 0.0840 | |
| SRP219564 | CYB5R4 | 51167 | RNAseq | -0.1984 | 0.4059 | |
| TCGA | CYB5R4 | 51167 | RNAseq | 0.0805 | 0.2382 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CYB5R4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYB5R4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYB5R4 | 51167 | 1 | 4 | 25 | |
| GSE20123 | CYB5R4 | 51167 | 1 | 3 | 26 | |
| GSE43470 | CYB5R4 | 51167 | 2 | 1 | 40 | |
| GSE46452 | CYB5R4 | 51167 | 2 | 11 | 46 | |
| GSE47630 | CYB5R4 | 51167 | 8 | 6 | 26 | |
| GSE54993 | CYB5R4 | 51167 | 3 | 2 | 65 | |
| GSE54994 | CYB5R4 | 51167 | 8 | 8 | 37 | |
| GSE60625 | CYB5R4 | 51167 | 0 | 1 | 10 | |
| GSE74703 | CYB5R4 | 51167 | 2 | 1 | 33 | |
| GSE74704 | CYB5R4 | 51167 | 0 | 2 | 18 | |
| TCGA | CYB5R4 | 51167 | 6 | 22 | 68 |
Total number of gains: 33; Total number of losses: 61; Total Number of normals: 394.
Somatic mutations of CYB5R4:
Generating mutation plots.
Highly correlated genes for CYB5R4:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYB5R4 | TBXAS1 | 0.722947 | 3 | 0 | 3 |
| CYB5R4 | IL10RA | 0.677794 | 3 | 0 | 3 |
| CYB5R4 | EVI2A | 0.663346 | 5 | 0 | 4 |
| CYB5R4 | CR2 | 0.662173 | 3 | 0 | 3 |
| CYB5R4 | KDM6A | 0.66205 | 3 | 0 | 3 |
| CYB5R4 | TBC1D9 | 0.659176 | 4 | 0 | 4 |
| CYB5R4 | ZC3H12D | 0.658686 | 3 | 0 | 3 |
| CYB5R4 | MICU2 | 0.631861 | 3 | 0 | 3 |
| CYB5R4 | ZMAT2 | 0.625311 | 4 | 0 | 3 |
| CYB5R4 | PCMT1 | 0.622185 | 4 | 0 | 3 |
| CYB5R4 | DUSP11 | 0.619906 | 5 | 0 | 4 |
| CYB5R4 | XBP1 | 0.619033 | 6 | 0 | 4 |
| CYB5R4 | SFT2D1 | 0.611399 | 7 | 0 | 6 |
| CYB5R4 | CD48 | 0.610834 | 4 | 0 | 3 |
| CYB5R4 | GIMAP2 | 0.606031 | 4 | 0 | 3 |
| CYB5R4 | PPP1R2 | 0.602042 | 5 | 0 | 3 |
| CYB5R4 | SMC4 | 0.596938 | 3 | 0 | 3 |
| CYB5R4 | TRAPPC11 | 0.596935 | 4 | 0 | 3 |
| CYB5R4 | TMCO1 | 0.596522 | 4 | 0 | 3 |
| CYB5R4 | CAAP1 | 0.59588 | 4 | 0 | 3 |
For details and further investigation, click here
