| Full name: ubiquitin like modifier activating enzyme 2 | Alias Symbol: FLJ13058|HRIHFB2115 | ||
| Type: protein-coding gene | Cytoband: 19q13.11 | ||
| Entrez ID: 10054 | HGNC ID: HGNC:30661 | Ensembl Gene: ENSG00000126261 | OMIM ID: 613295 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBA2 | 10054 | 201177_s_at | 0.3147 | 0.3387 | |
| GSE20347 | UBA2 | 10054 | 201177_s_at | 0.6483 | 0.0002 | |
| GSE23400 | UBA2 | 10054 | 201177_s_at | 0.7776 | 0.0000 | |
| GSE26886 | UBA2 | 10054 | 201177_s_at | 0.9275 | 0.0000 | |
| GSE29001 | UBA2 | 10054 | 201177_s_at | 0.7204 | 0.0400 | |
| GSE38129 | UBA2 | 10054 | 201177_s_at | 0.6568 | 0.0000 | |
| GSE45670 | UBA2 | 10054 | 201177_s_at | 0.1530 | 0.4544 | |
| GSE53622 | UBA2 | 10054 | 4002 | 0.3371 | 0.0000 | |
| GSE53624 | UBA2 | 10054 | 4002 | 0.4594 | 0.0000 | |
| GSE63941 | UBA2 | 10054 | 201177_s_at | 0.5155 | 0.1939 | |
| GSE77861 | UBA2 | 10054 | 201177_s_at | 0.5484 | 0.1270 | |
| GSE97050 | UBA2 | 10054 | A_33_P3383034 | 0.1487 | 0.6643 | |
| SRP007169 | UBA2 | 10054 | RNAseq | 0.5589 | 0.1191 | |
| SRP008496 | UBA2 | 10054 | RNAseq | 0.4495 | 0.0257 | |
| SRP064894 | UBA2 | 10054 | RNAseq | 0.6089 | 0.0087 | |
| SRP133303 | UBA2 | 10054 | RNAseq | 0.4408 | 0.0396 | |
| SRP159526 | UBA2 | 10054 | RNAseq | 0.7032 | 0.0090 | |
| SRP193095 | UBA2 | 10054 | RNAseq | 0.1953 | 0.0662 | |
| SRP219564 | UBA2 | 10054 | RNAseq | 0.0509 | 0.8078 | |
| TCGA | UBA2 | 10054 | RNAseq | 0.1411 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBA2 | 10054 | 6 | 5 | 19 | |
| GSE20123 | UBA2 | 10054 | 6 | 4 | 20 | |
| GSE43470 | UBA2 | 10054 | 5 | 7 | 31 | |
| GSE46452 | UBA2 | 10054 | 48 | 1 | 10 | |
| GSE47630 | UBA2 | 10054 | 9 | 5 | 26 | |
| GSE54993 | UBA2 | 10054 | 17 | 3 | 50 | |
| GSE54994 | UBA2 | 10054 | 9 | 9 | 35 | |
| GSE60625 | UBA2 | 10054 | 9 | 0 | 2 | |
| GSE74703 | UBA2 | 10054 | 5 | 4 | 27 | |
| GSE74704 | UBA2 | 10054 | 6 | 2 | 12 | |
| TCGA | UBA2 | 10054 | 19 | 11 | 66 |
Total number of gains: 139; Total number of losses: 51; Total Number of normals: 298.
Somatic mutations of UBA2:
Generating mutation plots.
Highly correlated genes for UBA2:
Showing top 20/1510 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBA2 | KLHL5 | 0.785813 | 3 | 0 | 3 |
| UBA2 | SLC39A13 | 0.774106 | 3 | 0 | 3 |
| UBA2 | DYRK2 | 0.773155 | 3 | 0 | 3 |
| UBA2 | KLHDC2 | 0.758125 | 3 | 0 | 3 |
| UBA2 | POLR1B | 0.75739 | 5 | 0 | 5 |
| UBA2 | SGTB | 0.751291 | 3 | 0 | 3 |
| UBA2 | UBE2W | 0.742598 | 3 | 0 | 3 |
| UBA2 | RIMKLB | 0.740926 | 3 | 0 | 3 |
| UBA2 | GPR158 | 0.734243 | 3 | 0 | 3 |
| UBA2 | SGMS1 | 0.733726 | 3 | 0 | 3 |
| UBA2 | FMR1 | 0.733169 | 5 | 0 | 4 |
| UBA2 | RAVER1 | 0.731135 | 3 | 0 | 3 |
| UBA2 | CISD2 | 0.730812 | 3 | 0 | 3 |
| UBA2 | CENPBD1 | 0.728891 | 3 | 0 | 3 |
| UBA2 | ZNF146 | 0.728826 | 13 | 0 | 11 |
| UBA2 | UBB | 0.726729 | 3 | 0 | 3 |
| UBA2 | PDCD2L | 0.723123 | 9 | 0 | 9 |
| UBA2 | SMCR8 | 0.721974 | 4 | 0 | 4 |
| UBA2 | PPHLN1 | 0.721859 | 4 | 0 | 3 |
| UBA2 | RPA2 | 0.717684 | 3 | 0 | 3 |
For details and further investigation, click here
