| Full name: SEC61 translocon alpha 1 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 29927 | HGNC ID: HGNC:18276 | Ensembl Gene: ENSG00000058262 | OMIM ID: 609213 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC61A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC61A1 | 29927 | 217716_s_at | 0.8650 | 0.0447 | |
| GSE20347 | SEC61A1 | 29927 | 217716_s_at | 0.5358 | 0.0000 | |
| GSE23400 | SEC61A1 | 29927 | 217716_s_at | 0.4723 | 0.0000 | |
| GSE26886 | SEC61A1 | 29927 | 217716_s_at | 0.1845 | 0.5563 | |
| GSE29001 | SEC61A1 | 29927 | 217716_s_at | 0.2596 | 0.5763 | |
| GSE38129 | SEC61A1 | 29927 | 217716_s_at | 0.6420 | 0.0000 | |
| GSE45670 | SEC61A1 | 29927 | 217716_s_at | 0.6701 | 0.0001 | |
| GSE53622 | SEC61A1 | 29927 | 49262 | 0.5980 | 0.0000 | |
| GSE53624 | SEC61A1 | 29927 | 49262 | 0.7063 | 0.0000 | |
| GSE63941 | SEC61A1 | 29927 | 217716_s_at | -0.6764 | 0.1575 | |
| GSE77861 | SEC61A1 | 29927 | 217716_s_at | 0.5592 | 0.0337 | |
| GSE97050 | SEC61A1 | 29927 | A_23_P212458 | 1.2950 | 0.0555 | |
| SRP007169 | SEC61A1 | 29927 | RNAseq | 0.6578 | 0.0821 | |
| SRP008496 | SEC61A1 | 29927 | RNAseq | 0.7492 | 0.0015 | |
| SRP064894 | SEC61A1 | 29927 | RNAseq | 0.8747 | 0.0000 | |
| SRP133303 | SEC61A1 | 29927 | RNAseq | 0.8927 | 0.0000 | |
| SRP159526 | SEC61A1 | 29927 | RNAseq | 0.4957 | 0.0016 | |
| SRP193095 | SEC61A1 | 29927 | RNAseq | 0.4256 | 0.0008 | |
| SRP219564 | SEC61A1 | 29927 | RNAseq | 0.8039 | 0.0138 | |
| TCGA | SEC61A1 | 29927 | RNAseq | -0.0086 | 0.8315 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC61A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC61A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC61A1 | 29927 | 17 | 0 | 13 | |
| GSE20123 | SEC61A1 | 29927 | 17 | 0 | 13 | |
| GSE43470 | SEC61A1 | 29927 | 19 | 0 | 24 | |
| GSE46452 | SEC61A1 | 29927 | 14 | 5 | 40 | |
| GSE47630 | SEC61A1 | 29927 | 17 | 4 | 19 | |
| GSE54993 | SEC61A1 | 29927 | 2 | 7 | 61 | |
| GSE54994 | SEC61A1 | 29927 | 31 | 3 | 19 | |
| GSE60625 | SEC61A1 | 29927 | 0 | 6 | 5 | |
| GSE74703 | SEC61A1 | 29927 | 17 | 0 | 19 | |
| GSE74704 | SEC61A1 | 29927 | 13 | 0 | 7 | |
| TCGA | SEC61A1 | 29927 | 56 | 5 | 35 |
Total number of gains: 203; Total number of losses: 30; Total Number of normals: 255.
Somatic mutations of SEC61A1:
Generating mutation plots.
Highly correlated genes for SEC61A1:
Showing top 20/1390 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC61A1 | ANKRD54 | 0.805911 | 3 | 0 | 3 |
| SEC61A1 | TULP4 | 0.79977 | 3 | 0 | 3 |
| SEC61A1 | RPN1 | 0.794103 | 11 | 0 | 10 |
| SEC61A1 | ZBTB9 | 0.789903 | 4 | 0 | 4 |
| SEC61A1 | RNF217 | 0.775115 | 3 | 0 | 3 |
| SEC61A1 | CLPTM1L | 0.773663 | 6 | 0 | 6 |
| SEC61A1 | RNF166 | 0.771654 | 3 | 0 | 3 |
| SEC61A1 | C8orf76 | 0.771479 | 4 | 0 | 4 |
| SEC61A1 | MCM3AP | 0.768163 | 3 | 0 | 3 |
| SEC61A1 | POLR1B | 0.767227 | 4 | 0 | 4 |
| SEC61A1 | ARHGDIA | 0.765575 | 3 | 0 | 3 |
| SEC61A1 | MLLT1 | 0.763286 | 4 | 0 | 4 |
| SEC61A1 | PPP1R9B | 0.762182 | 3 | 0 | 3 |
| SEC61A1 | SETX | 0.760002 | 3 | 0 | 3 |
| SEC61A1 | MARS2 | 0.757332 | 3 | 0 | 3 |
| SEC61A1 | ALG1 | 0.756981 | 4 | 0 | 4 |
| SEC61A1 | LRRC58 | 0.751786 | 5 | 0 | 4 |
| SEC61A1 | PDCD2L | 0.746935 | 4 | 0 | 4 |
| SEC61A1 | RBM15B | 0.743317 | 3 | 0 | 3 |
| SEC61A1 | COMMD2 | 0.742815 | 4 | 0 | 4 |
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