| Full name: 5-oxoprolinase, ATP-hydrolysing | Alias Symbol: OPLA|5-Opase | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 26873 | HGNC ID: HGNC:8149 | Ensembl Gene: ENSG00000178814 | OMIM ID: 614243 |
| Drug and gene relationship at DGIdb | |||
Expression of OPLAH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OPLAH | 26873 | 222025_s_at | 0.5880 | 0.3190 | |
| GSE20347 | OPLAH | 26873 | 222025_s_at | -0.2276 | 0.1784 | |
| GSE23400 | OPLAH | 26873 | 222025_s_at | -0.0912 | 0.3255 | |
| GSE26886 | OPLAH | 26873 | 222025_s_at | 0.6074 | 0.0153 | |
| GSE29001 | OPLAH | 26873 | 222025_s_at | -0.4674 | 0.2131 | |
| GSE38129 | OPLAH | 26873 | 222025_s_at | -0.0846 | 0.6606 | |
| GSE45670 | OPLAH | 26873 | 222025_s_at | -0.0684 | 0.7617 | |
| GSE63941 | OPLAH | 26873 | 222025_s_at | 0.2028 | 0.7312 | |
| GSE77861 | OPLAH | 26873 | 222025_s_at | -0.1898 | 0.6478 | |
| GSE97050 | OPLAH | 26873 | A_23_P170186 | 0.2490 | 0.3815 | |
| SRP007169 | OPLAH | 26873 | RNAseq | -1.1781 | 0.0027 | |
| SRP008496 | OPLAH | 26873 | RNAseq | -1.3889 | 0.0000 | |
| SRP064894 | OPLAH | 26873 | RNAseq | -0.0708 | 0.7908 | |
| SRP133303 | OPLAH | 26873 | RNAseq | -0.0265 | 0.9323 | |
| SRP159526 | OPLAH | 26873 | RNAseq | 0.0297 | 0.9172 | |
| SRP193095 | OPLAH | 26873 | RNAseq | 0.2749 | 0.1378 | |
| TCGA | OPLAH | 26873 | RNAseq | -0.1766 | 0.0485 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by OPLAH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of OPLAH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OPLAH | 26873 | 17 | 1 | 12 | |
| GSE20123 | OPLAH | 26873 | 17 | 1 | 12 | |
| GSE43470 | OPLAH | 26873 | 16 | 2 | 25 | |
| GSE46452 | OPLAH | 26873 | 27 | 0 | 32 | |
| GSE47630 | OPLAH | 26873 | 23 | 1 | 16 | |
| GSE54993 | OPLAH | 26873 | 0 | 25 | 45 | |
| GSE54994 | OPLAH | 26873 | 39 | 1 | 13 | |
| GSE60625 | OPLAH | 26873 | 3 | 4 | 4 | |
| GSE74703 | OPLAH | 26873 | 14 | 1 | 21 | |
| GSE74704 | OPLAH | 26873 | 10 | 0 | 10 | |
| TCGA | OPLAH | 26873 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of OPLAH:
Generating mutation plots.
Highly correlated genes for OPLAH:
Showing top 20/187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OPLAH | PDCD2L | 0.773643 | 3 | 0 | 3 |
| OPLAH | SPIRE2 | 0.767336 | 3 | 0 | 3 |
| OPLAH | POLR1B | 0.765235 | 3 | 0 | 3 |
| OPLAH | HS6ST1 | 0.763658 | 3 | 0 | 3 |
| OPLAH | MAP1S | 0.745639 | 3 | 0 | 3 |
| OPLAH | ZNF680 | 0.744708 | 3 | 0 | 3 |
| OPLAH | LARP1 | 0.738159 | 3 | 0 | 3 |
| OPLAH | LSR | 0.730988 | 3 | 0 | 3 |
| OPLAH | KIAA0930 | 0.72377 | 3 | 0 | 3 |
| OPLAH | CSNK1G2 | 0.723107 | 3 | 0 | 3 |
| OPLAH | MRPL48 | 0.722218 | 3 | 0 | 3 |
| OPLAH | LRRC58 | 0.720838 | 3 | 0 | 3 |
| OPLAH | C1orf131 | 0.720019 | 3 | 0 | 3 |
| OPLAH | NAT10 | 0.719276 | 3 | 0 | 3 |
| OPLAH | NOM1 | 0.714291 | 3 | 0 | 3 |
| OPLAH | TSEN15 | 0.708982 | 3 | 0 | 3 |
| OPLAH | SURF6 | 0.708599 | 3 | 0 | 3 |
| OPLAH | TTC30B | 0.708387 | 3 | 0 | 3 |
| OPLAH | DAP3 | 0.705464 | 3 | 0 | 3 |
| OPLAH | ACIN1 | 0.702844 | 3 | 0 | 3 |
For details and further investigation, click here
