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File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Function: drawSurvPlot

File: /data/webapp/var/www/html/ESCCdb/index.php
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Function: require_once

Multi-Omics Database of ESCC

 

OPLAH

 

Full name: 5-oxoprolinase, ATP-hydrolysing Alias Symbol: OPLA|5-Opase
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 26873 HGNC ID: HGNC:8149 Ensembl Gene: ENSG00000178814 OMIM ID: 614243
Drug and gene relationship at DGIdb

 

Expression of OPLAH:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 OPLAH 26873 222025_s_at 0.5880 0.3190
GSE20347 OPLAH 26873 222025_s_at -0.2276 0.1784
GSE23400 OPLAH 26873 222025_s_at -0.0912 0.3255
GSE26886 OPLAH 26873 222025_s_at 0.6074 0.0153
GSE29001 OPLAH 26873 222025_s_at -0.4674 0.2131
GSE38129 OPLAH 26873 222025_s_at -0.0846 0.6606
GSE45670 OPLAH 26873 222025_s_at -0.0684 0.7617
GSE63941 OPLAH 26873 222025_s_at 0.2028 0.7312
GSE77861 OPLAH 26873 222025_s_at -0.1898 0.6478
GSE97050 OPLAH 26873 A_23_P170186 0.2490 0.3815
SRP007169 OPLAH 26873 RNAseq -1.1781 0.0027
SRP008496 OPLAH 26873 RNAseq -1.3889 0.0000
SRP064894 OPLAH 26873 RNAseq -0.0708 0.7908
SRP133303 OPLAH 26873 RNAseq -0.0265 0.9323
SRP159526 OPLAH 26873 RNAseq 0.0297 0.9172
SRP193095 OPLAH 26873 RNAseq 0.2749 0.1378
TCGA OPLAH 26873 RNAseq -0.1766 0.0485

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by OPLAH expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of OPLAH:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 OPLAH 26873 17 1 12
GSE20123 OPLAH 26873 17 1 12
GSE43470 OPLAH 26873 16 2 25
GSE46452 OPLAH 26873 27 0 32
GSE47630 OPLAH 26873 23 1 16
GSE54993 OPLAH 26873 0 25 45
GSE54994 OPLAH 26873 39 1 13
GSE60625 OPLAH 26873 3 4 4
GSE74703 OPLAH 26873 14 1 21
GSE74704 OPLAH 26873 10 0 10
TCGA OPLAH 26873 63 2 31

Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.  

 

Somatic mutations of OPLAH:

 

Generating mutation plots.

 

Highly correlated genes for OPLAH:

 

Showing top 20/187 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
OPLAHPDCD2L0.773643303
OPLAHSPIRE20.767336303
OPLAHPOLR1B0.765235303
OPLAHHS6ST10.763658303
OPLAHMAP1S0.745639303
OPLAHZNF6800.744708303
OPLAHLARP10.738159303
OPLAHLSR0.730988303
OPLAHKIAA09300.72377303
OPLAHCSNK1G20.723107303
OPLAHMRPL480.722218303
OPLAHLRRC580.720838303
OPLAHC1orf1310.720019303
OPLAHNAT100.719276303
OPLAHNOM10.714291303
OPLAHTSEN150.708982303
OPLAHSURF60.708599303
OPLAHTTC30B0.708387303
OPLAHDAP30.705464303
OPLAHACIN10.702844303

For details and further investigation, click here