| Full name: RNA polymerase II subunit E | Alias Symbol: RPB5|RPABC1|XAP4|hRPB25|hsRPB5 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 5434 | HGNC ID: HGNC:9192 | Ensembl Gene: ENSG00000099817 | OMIM ID: 180664 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2E | 5434 | 217854_s_at | 0.0689 | 0.8250 | |
| GSE20347 | POLR2E | 5434 | 217854_s_at | -0.0473 | 0.7418 | |
| GSE23400 | POLR2E | 5434 | 217854_s_at | 0.0782 | 0.2234 | |
| GSE26886 | POLR2E | 5434 | 217854_s_at | 0.1474 | 0.6036 | |
| GSE29001 | POLR2E | 5434 | 217854_s_at | -0.1833 | 0.5064 | |
| GSE38129 | POLR2E | 5434 | 217854_s_at | 0.0428 | 0.7366 | |
| GSE45670 | POLR2E | 5434 | 217854_s_at | -0.0244 | 0.8791 | |
| GSE53622 | POLR2E | 5434 | 111090 | -0.1270 | 0.0077 | |
| GSE53624 | POLR2E | 5434 | 111090 | 0.1615 | 0.0022 | |
| GSE63941 | POLR2E | 5434 | 217854_s_at | 0.7821 | 0.0403 | |
| GSE77861 | POLR2E | 5434 | 217854_s_at | 0.1255 | 0.5483 | |
| GSE97050 | POLR2E | 5434 | A_33_P3299829 | 0.0265 | 0.9141 | |
| SRP007169 | POLR2E | 5434 | RNAseq | -0.3469 | 0.2894 | |
| SRP008496 | POLR2E | 5434 | RNAseq | -0.3922 | 0.1143 | |
| SRP064894 | POLR2E | 5434 | RNAseq | 0.3128 | 0.2616 | |
| SRP133303 | POLR2E | 5434 | RNAseq | 0.1454 | 0.3996 | |
| SRP159526 | POLR2E | 5434 | RNAseq | 0.1052 | 0.4433 | |
| SRP193095 | POLR2E | 5434 | RNAseq | -0.1315 | 0.3224 | |
| SRP219564 | POLR2E | 5434 | RNAseq | -0.1973 | 0.6647 | |
| TCGA | POLR2E | 5434 | RNAseq | 0.0504 | 0.2744 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLR2E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR2E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2E | 5434 | 4 | 6 | 20 | |
| GSE20123 | POLR2E | 5434 | 4 | 5 | 21 | |
| GSE43470 | POLR2E | 5434 | 1 | 9 | 33 | |
| GSE46452 | POLR2E | 5434 | 47 | 1 | 11 | |
| GSE47630 | POLR2E | 5434 | 5 | 7 | 28 | |
| GSE54993 | POLR2E | 5434 | 13 | 4 | 53 | |
| GSE54994 | POLR2E | 5434 | 8 | 15 | 30 | |
| GSE60625 | POLR2E | 5434 | 9 | 0 | 2 | |
| GSE74703 | POLR2E | 5434 | 1 | 7 | 28 | |
| GSE74704 | POLR2E | 5434 | 3 | 3 | 14 | |
| TCGA | POLR2E | 5434 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 82; Total Number of normals: 303.
Somatic mutations of POLR2E:
Generating mutation plots.
Highly correlated genes for POLR2E:
Showing top 20/245 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2E | MED14 | 0.7737 | 3 | 0 | 3 |
| POLR2E | SPNS1 | 0.75308 | 3 | 0 | 3 |
| POLR2E | XPNPEP1 | 0.711504 | 3 | 0 | 3 |
| POLR2E | XRCC6 | 0.711016 | 4 | 0 | 4 |
| POLR2E | HECTD3 | 0.707255 | 3 | 0 | 3 |
| POLR2E | UBE2J2 | 0.693173 | 3 | 0 | 3 |
| POLR2E | NOC2L | 0.677483 | 4 | 0 | 4 |
| POLR2E | CSTF2T | 0.676164 | 3 | 0 | 3 |
| POLR2E | MRPL38 | 0.675264 | 5 | 0 | 5 |
| POLR2E | TBCD | 0.674905 | 3 | 0 | 3 |
| POLR2E | MTCH2 | 0.669249 | 3 | 0 | 3 |
| POLR2E | EIF3I | 0.667885 | 4 | 0 | 4 |
| POLR2E | RPUSD2 | 0.661656 | 3 | 0 | 3 |
| POLR2E | FGGY | 0.660033 | 3 | 0 | 3 |
| POLR2E | ADAD2 | 0.656651 | 5 | 0 | 3 |
| POLR2E | E4F1 | 0.655423 | 3 | 0 | 3 |
| POLR2E | LSM4 | 0.655293 | 4 | 0 | 4 |
| POLR2E | SLC25A13 | 0.654941 | 3 | 0 | 3 |
| POLR2E | RPS19BP1 | 0.654139 | 3 | 0 | 3 |
| POLR2E | SFPQ | 0.653105 | 3 | 0 | 3 |
For details and further investigation, click here
