| Full name: pre-mRNA processing factor 3 | Alias Symbol: Prp3|hPrp3|SNRNP90 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 9129 | HGNC ID: HGNC:17348 | Ensembl Gene: ENSG00000117360 | OMIM ID: 607301 |
| Drug and gene relationship at DGIdb | |||
Expression of PRPF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPF3 | 9129 | 202251_at | 0.2884 | 0.4066 | |
| GSE20347 | PRPF3 | 9129 | 202251_at | 0.2775 | 0.0806 | |
| GSE23400 | PRPF3 | 9129 | 202251_at | 0.4359 | 0.0000 | |
| GSE26886 | PRPF3 | 9129 | 202251_at | -0.2829 | 0.3191 | |
| GSE29001 | PRPF3 | 9129 | 202251_at | 0.4684 | 0.0889 | |
| GSE38129 | PRPF3 | 9129 | 202251_at | 0.3399 | 0.0056 | |
| GSE45670 | PRPF3 | 9129 | 202251_at | 0.1623 | 0.3083 | |
| GSE53622 | PRPF3 | 9129 | 129416 | 0.3474 | 0.0000 | |
| GSE53624 | PRPF3 | 9129 | 129416 | 0.3257 | 0.0000 | |
| GSE63941 | PRPF3 | 9129 | 202251_at | 0.7290 | 0.0890 | |
| GSE77861 | PRPF3 | 9129 | 202251_at | 0.7633 | 0.0060 | |
| GSE97050 | PRPF3 | 9129 | A_23_P97573 | 0.0488 | 0.8351 | |
| SRP007169 | PRPF3 | 9129 | RNAseq | 1.0964 | 0.0623 | |
| SRP008496 | PRPF3 | 9129 | RNAseq | 1.5842 | 0.0028 | |
| SRP064894 | PRPF3 | 9129 | RNAseq | 0.1579 | 0.2784 | |
| SRP133303 | PRPF3 | 9129 | RNAseq | 0.1253 | 0.4591 | |
| SRP159526 | PRPF3 | 9129 | RNAseq | 0.2369 | 0.2534 | |
| SRP193095 | PRPF3 | 9129 | RNAseq | 0.3094 | 0.0016 | |
| SRP219564 | PRPF3 | 9129 | RNAseq | 0.3264 | 0.3128 | |
| TCGA | PRPF3 | 9129 | RNAseq | 0.1217 | 0.0236 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PRPF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPF3 | 9129 | 15 | 0 | 15 | |
| GSE20123 | PRPF3 | 9129 | 15 | 0 | 15 | |
| GSE43470 | PRPF3 | 9129 | 6 | 1 | 36 | |
| GSE46452 | PRPF3 | 9129 | 2 | 1 | 56 | |
| GSE47630 | PRPF3 | 9129 | 14 | 0 | 26 | |
| GSE54993 | PRPF3 | 9129 | 0 | 3 | 67 | |
| GSE54994 | PRPF3 | 9129 | 15 | 0 | 38 | |
| GSE60625 | PRPF3 | 9129 | 0 | 0 | 11 | |
| GSE74703 | PRPF3 | 9129 | 6 | 1 | 29 | |
| GSE74704 | PRPF3 | 9129 | 7 | 0 | 13 | |
| TCGA | PRPF3 | 9129 | 38 | 2 | 56 |
Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.
Somatic mutations of PRPF3:
Generating mutation plots.
Highly correlated genes for PRPF3:
Showing top 20/132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPF3 | ARL8A | 0.726995 | 3 | 0 | 3 |
| PRPF3 | TIGD7 | 0.722112 | 4 | 0 | 4 |
| PRPF3 | POLR3A | 0.689314 | 3 | 0 | 3 |
| PRPF3 | ARHGAP22 | 0.68349 | 3 | 0 | 3 |
| PRPF3 | GTF2IRD2 | 0.6538 | 4 | 0 | 3 |
| PRPF3 | CCDC142 | 0.637483 | 4 | 0 | 3 |
| PRPF3 | GXYLT1 | 0.635444 | 3 | 0 | 3 |
| PRPF3 | FBRSL1 | 0.632523 | 5 | 0 | 3 |
| PRPF3 | COL27A1 | 0.62863 | 4 | 0 | 3 |
| PRPF3 | SART1 | 0.625877 | 4 | 0 | 3 |
| PRPF3 | ANXA10 | 0.618892 | 4 | 0 | 3 |
| PRPF3 | TAGLN2 | 0.617025 | 6 | 0 | 6 |
| PRPF3 | RAD54L2 | 0.615996 | 4 | 0 | 3 |
| PRPF3 | NEURL4 | 0.609571 | 3 | 0 | 3 |
| PRPF3 | HOXC9 | 0.608465 | 4 | 0 | 3 |
| PRPF3 | MFSD10 | 0.602901 | 5 | 0 | 4 |
| PRPF3 | C5orf30 | 0.598453 | 5 | 0 | 3 |
| PRPF3 | DHX34 | 0.59842 | 6 | 0 | 4 |
| PRPF3 | DVL2 | 0.5978 | 5 | 0 | 3 |
| PRPF3 | PUS1 | 0.594313 | 7 | 0 | 5 |
For details and further investigation, click here
