| Full name: POU class 4 homeobox 1 | Alias Symbol: RDC-1 | ||
| Type: protein-coding gene | Cytoband: 13q31.1 | ||
| Entrez ID: 5457 | HGNC ID: HGNC:9218 | Ensembl Gene: ENSG00000152192 | OMIM ID: 601632 |
| Drug and gene relationship at DGIdb | |||
Expression of POU4F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU4F1 | 5457 | 206940_s_at | 0.6040 | 0.2527 | |
| GSE20347 | POU4F1 | 5457 | 206940_s_at | 0.3818 | 0.0091 | |
| GSE23400 | POU4F1 | 5457 | 206940_s_at | 0.0612 | 0.2219 | |
| GSE26886 | POU4F1 | 5457 | 211341_at | 0.5655 | 0.0062 | |
| GSE29001 | POU4F1 | 5457 | 206940_s_at | 0.5168 | 0.1165 | |
| GSE38129 | POU4F1 | 5457 | 206940_s_at | 0.2344 | 0.0593 | |
| GSE45670 | POU4F1 | 5457 | 206940_s_at | 0.5934 | 0.0807 | |
| GSE53622 | POU4F1 | 5457 | 51696 | 0.6229 | 0.0000 | |
| GSE53624 | POU4F1 | 5457 | 51696 | 0.6343 | 0.0000 | |
| GSE63941 | POU4F1 | 5457 | 206940_s_at | 0.2079 | 0.7701 | |
| GSE77861 | POU4F1 | 5457 | 211341_at | -0.1140 | 0.4228 | |
| TCGA | POU4F1 | 5457 | RNAseq | 2.7648 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by POU4F1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU4F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU4F1 | 5457 | 3 | 11 | 16 | |
| GSE20123 | POU4F1 | 5457 | 3 | 10 | 17 | |
| GSE43470 | POU4F1 | 5457 | 4 | 11 | 28 | |
| GSE46452 | POU4F1 | 5457 | 0 | 32 | 27 | |
| GSE47630 | POU4F1 | 5457 | 3 | 27 | 10 | |
| GSE54993 | POU4F1 | 5457 | 11 | 3 | 56 | |
| GSE54994 | POU4F1 | 5457 | 3 | 14 | 36 | |
| GSE60625 | POU4F1 | 5457 | 0 | 3 | 8 | |
| GSE74703 | POU4F1 | 5457 | 3 | 9 | 24 | |
| GSE74704 | POU4F1 | 5457 | 1 | 9 | 10 | |
| TCGA | POU4F1 | 5457 | 12 | 33 | 51 |
Total number of gains: 43; Total number of losses: 162; Total Number of normals: 283.
Somatic mutations of POU4F1:
Generating mutation plots.
Highly correlated genes for POU4F1:
Showing top 20/92 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU4F1 | B4GALT7 | 0.73059 | 3 | 0 | 3 |
| POU4F1 | RUVBL2 | 0.701629 | 3 | 0 | 3 |
| POU4F1 | ZNF579 | 0.697874 | 3 | 0 | 3 |
| POU4F1 | LRFN1 | 0.690433 | 4 | 0 | 3 |
| POU4F1 | JRK | 0.678305 | 3 | 0 | 3 |
| POU4F1 | DGKZ | 0.675014 | 4 | 0 | 3 |
| POU4F1 | ZNF444 | 0.672283 | 3 | 0 | 3 |
| POU4F1 | ISOC2 | 0.661974 | 3 | 0 | 3 |
| POU4F1 | MSLN | 0.651148 | 3 | 0 | 3 |
| POU4F1 | PPP6R1 | 0.650487 | 4 | 0 | 3 |
| POU4F1 | RHPN1 | 0.649077 | 4 | 0 | 4 |
| POU4F1 | TMC6 | 0.641809 | 3 | 0 | 3 |
| POU4F1 | REM2 | 0.640725 | 3 | 0 | 3 |
| POU4F1 | ZNF787 | 0.637178 | 3 | 0 | 3 |
| POU4F1 | ZNF358 | 0.633266 | 3 | 0 | 3 |
| POU4F1 | ZNF584 | 0.629457 | 4 | 0 | 3 |
| POU4F1 | MAST2 | 0.623306 | 3 | 0 | 3 |
| POU4F1 | KCNF1 | 0.618673 | 3 | 0 | 3 |
| POU4F1 | ZNF107 | 0.618162 | 3 | 0 | 3 |
| POU4F1 | TRPM2-AS | 0.617179 | 3 | 0 | 3 |
For details and further investigation, click here
